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5  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: CD5R1_HUMAN (Q15078)

Summary

This is the summary of UniProt entry CD5R1_HUMAN (Q15078).

Description: Cyclin-dependent kinase 5 activator 1
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 307 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
disorder n/a 27 43
low_complexity n/a 56 68
disorder n/a 60 80
disorder n/a 97 132
low_complexity n/a 99 111
Pfam CDK5_activator 103 295
low_complexity n/a 112 124
disorder n/a 136 137

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q15078. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MGTVLSLSPS YRKATLFEDG AATVGHYTAV QNSKNAKDKN LKRHSIISVL
50
51
PWKRIVAVSA KKKNSKKVQP NSSYQNNITH LNNENLKKSL SCANLSTFAQ
100
101
PPPAQPPAPP ASQLSGSQTG GSSSVKKAPH PAVTSAGTPK RVIVQASTSE
150
151
LLRCLGEFLC RRCYRLKHLS PTDPVLWLRS VDRSLLLQGW QDQGFITPAN
200
201
VVFLYMLCRD VISSEVGSDH ELQAVLLTCL YLSYSYMGNE ISYPLKPFLV
250
251
ESCKEAFWDR CLSVINLMSS KMLQINADPH YFTQVFSDLK NESGQEDKKR
300
301
LLLGLDR                                               
307
 

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Checksums:
CRC64:D1C29A07AFF1B644
MD5:0e87cf141203a6533fc1d85ac983a48e

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
CDK5_activator 145 - 293 3O0G D 145 - 293 Show 3D Structure View in InterPro
E 145 - 293 Show 3D Structure View in InterPro
145 - 294 1UNG D 145 - 294 Show 3D Structure View in InterPro
1UNL D 145 - 294 Show 3D Structure View in InterPro
E 145 - 294 Show 3D Structure View in InterPro
147 - 293 1H4L D 147 - 293 Show 3D Structure View in InterPro
E 147 - 293 Show 3D Structure View in InterPro
147 - 294 1UNG E 147 - 294 Show 3D Structure View in InterPro
1UNH D 147 - 294 Show 3D Structure View in InterPro
E 147 - 294 Show 3D Structure View in InterPro
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The parts of the structure corresponding to the Pfam family are highlighted in blue.

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TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;