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14  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: TERF2_HUMAN (Q15554)

Summary

This is the summary of UniProt entry TERF2_HUMAN (Q15554).

Description: Telomeric repeat-binding factor 2
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 542 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
disorder n/a 1 86
low_complexity n/a 2 15
low_complexity n/a 25 39
low_complexity n/a 44 72
low_complexity n/a 74 93
Pfam TRF 94 293
disorder n/a 219 221
disorder n/a 224 226
disorder n/a 232 234
low_complexity n/a 282 294
disorder n/a 288 335
Pfam TERF2_RBM 318 358
disorder n/a 341 492
low_complexity n/a 460 470
Pfam Myb_DNA-binding 489 537

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q15554. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MAAGAGTAGP ASGPGVVRDP AASQPRKRPG REGGEGARRS DTMAGGGGSS
50
51
DGSGRAAGRR ASRSSGRARR GRHEPGLGGP AERGAGEARL EEAVNRWVLK
100
101
FYFHEALRAF RGSRYGDFRQ IRDIMQALLV RPLGKEHTVS RLLRVMQCLS
150
151
RIEEGENLDC SFDMEAELTP LESAINVLEM IKTEFTLTEA VVESSRKLVK
200
201
EAAVIICIKN KEFEKASKIL KKHMSKDPTT QKLRNDLLNI IREKNLAHPV
250
251
IQNFSYETFQ QKMLRFLESH LDDAEPYLLT MAKKALKSES AASSTGKEDK
300
301
QPAPGPVEKP PREPARQLRN PPTTIGMMTL KAAFKTLSGA QDSEAAFAKL
350
351
DQKDLVLPTQ ALPASPALKN KRPRKDENES SAPADGEGGS ELQPKNKRMT
400
401
ISRLVLEEDS QSTEPSAGLN SSQEAASAPP SKPTVLNQPL PGEKNPKVPK
450
451
GKWNSSNGVE EKETWVEEDE LFQVQAAPDE DSTTNITKKQ KWTVEESEWV
500
501
KAGVQKYGEG NWAAISKNYP FVNRTAVMIK DRWRTMKRLG MN        
542
 

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Checksums:
CRC64:3A278AC6B594C43A
MD5:dbb9c0a3136397bd489e6e5ba9cee206

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Myb_DNA-binding 489 - 537 1VF9 A 447 - 495 NGL View in InterPro
1VFC A 447 - 495 NGL View in InterPro
1W0U A 447 - 495 NGL View in InterPro
B 447 - 495 NGL View in InterPro
1XG1 A 14 - 62 NGL View in InterPro
3SJM A 447 - 495 NGL View in InterPro
B 447 - 495 NGL View in InterPro
TERF2_RBM 323 - 355 3K6G F 281 - 313 NGL View in InterPro
323 - 358 3K6G E 281 - 316 NGL View in InterPro
324 - 356 3K6G D 282 - 314 NGL View in InterPro
TRF 94 - 283 5WQD G 52 - 241 NGL View in InterPro
94 - 285 5WQD E 52 - 243 NGL View in InterPro
7C5D B 52 - 243 NGL View in InterPro
94 - 286 1H6P B 1052 - 1244 NGL View in InterPro
4M7C A 52 - 244 NGL View in InterPro
B 52 - 244 NGL View in InterPro
5WQD B 52 - 244 NGL View in InterPro
F 52 - 244 NGL View in InterPro
7C5D A 52 - 244 NGL View in InterPro
94 - 287 1H6P A 52 - 245 NGL View in InterPro
3BUA A 52 - 245 NGL View in InterPro
B 52 - 245 NGL View in InterPro
C 52 - 245 NGL View in InterPro
D 52 - 245 NGL View in InterPro
4RQI A 52 - 245 NGL View in InterPro
B 52 - 245 NGL View in InterPro
C 52 - 245 NGL View in InterPro
D 52 - 245 NGL View in InterPro
5WQD A 52 - 245 NGL View in InterPro
C 52 - 245 NGL View in InterPro
D 52 - 245 NGL View in InterPro
6J67 A 52 - 245 NGL View in InterPro
94 - 289 3BU8 A 52 - 247 NGL View in InterPro
94 - 291 3BU8 B 52 - 249 NGL View in InterPro
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TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.