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12  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: SCN9A_HUMAN (Q15858)

Summary

This is the summary of UniProt entry SCN9A_HUMAN (Q15858).

Description: Sodium channel protein type 9 subunit alpha {ECO:0000305}
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 1988 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
disorder n/a 1 3
disorder n/a 7 8
disorder n/a 26 51
low_complexity n/a 28 50
transmembrane n/a 122 145
Pfam Ion_trans 125 412
transmembrane n/a 190 209
transmembrane n/a 221 242
transmembrane n/a 248 268
coiled_coil n/a 276 296
transmembrane n/a 378 405
coiled_coil n/a 402 447
low_complexity n/a 433 446
low_complexity n/a 458 472
disorder n/a 461 543
low_complexity n/a 469 490
Pfam Na_trans_cytopl 535 694
disorder n/a 555 558
disorder n/a 565 566
disorder n/a 568 577
disorder n/a 581 618
disorder n/a 650 652
disorder n/a 656 658
disorder n/a 660 662
coiled_coil n/a 686 706
transmembrane n/a 737 763
Pfam Ion_trans 743 978
transmembrane n/a 775 793
transmembrane n/a 813 834
low_complexity n/a 831 843
transmembrane n/a 855 883
low_complexity n/a 871 883
transmembrane n/a 913 933
transmembrane n/a 945 968
low_complexity n/a 957 976
Pfam Na_trans_assoc 982 1187
coiled_coil n/a 1020 1040
disorder n/a 1025 1026
disorder n/a 1064 1067
disorder n/a 1072 1075
disorder n/a 1082 1086
disorder n/a 1090 1094
disorder n/a 1096 1107
low_complexity n/a 1104 1115
disorder n/a 1128 1148
low_complexity n/a 1135 1145
Pfam Ion_trans 1191 1468
transmembrane n/a 1193 1211
transmembrane n/a 1232 1248
transmembrane n/a 1260 1279
low_complexity n/a 1288 1303
transmembrane n/a 1300 1318
transmembrane n/a 1324 1344
transmembrane n/a 1393 1414
transmembrane n/a 1434 1457
Pfam Ion_trans 1514 1771
transmembrane n/a 1516 1534
transmembrane n/a 1546 1564
transmembrane n/a 1576 1596
low_complexity n/a 1580 1591
transmembrane n/a 1602 1621
low_complexity n/a 1610 1623
transmembrane n/a 1633 1661
disorder n/a 1718 1723
transmembrane n/a 1737 1760
low_complexity n/a 1737 1748
disorder n/a 1860 1865
disorder n/a 1870 1872
disorder n/a 1878 1883
disorder n/a 1927 1988
low_complexity n/a 1946 1962
low_complexity n/a 1975 1988

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q15858. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MAMLPPPGPQ SFVHFTKQSL ALIEQRIAER KSKEPKEEKK DDDEEAPKPS
50
51
SDLEAGKQLP FIYGDIPPGM VSEPLEDLDP YYADKKTFIV LNKGKTIFRF
100
101
NATPALYMLS PFSPLRRISI KILVHSLFSM LIMCTILTNC IFMTMNNPPD
150
151
WTKNVEYTFT GIYTFESLVK ILARGFCVGE FTFLRDPWNW LDFVVIVFAY
200
201
LTEFVNLGNV SALRTFRVLR ALKTISVIPG LKTIVGALIQ SVKKLSDVMI
250
251
LTVFCLSVFA LIGLQLFMGN LKHKCFRNSL ENNETLESIM NTLESEEDFR
300
301
KYFYYLEGSK DALLCGFSTD SGQCPEGYTC VKIGRNPDYG YTSFDTFSWA
350
351
FLALFRLMTQ DYWENLYQQT LRAAGKTYMI FFVVVIFLGS FYLINLILAV
400
401
VAMAYEEQNQ ANIEEAKQKE LEFQQMLDRL KKEQEEAEAI AAAAAEYTSI
450
451
RRSRIMGLSE SSSETSKLSS KSAKERRNRR KKKNQKKLSS GEEKGDAEKL
500
501
SKSESEDSIR RKSFHLGVEG HRRAHEKRLS TPNQSPLSIR GSLFSARRSS
550
551
RTSLFSFKGR GRDIGSETEF ADDEHSIFGD NESRRGSLFV PHRPQERRSS
600
601
NISQASRSPP MLPVNGKMHS AVDCNGVVSL VDGRSALMLP NGQLLPEVII
650
651
DKATSDDSGT TNQIHKKRRC SSYLLSEDML NDPNLRQRAM SRASILTNTV
700
701
EELEESRQKC PPWWYRFAHK FLIWNCSPYW IKFKKCIYFI VMDPFVDLAI
750
751
TICIVLNTLF MAMEHHPMTE EFKNVLAIGN LVFTGIFAAE MVLKLIAMDP
800
801
YEYFQVGWNI FDSLIVTLSL VELFLADVEG LSVLRSFRLL RVFKLAKSWP
850
851
TLNMLIKIIG NSVGALGNLT LVLAIIVFIF AVVGMQLFGK SYKECVCKIN
900
901
DDCTLPRWHM NDFFHSFLIV FRVLCGEWIE TMWDCMEVAG QAMCLIVYMM
950
951
VMVIGNLVVL NLFLALLLSS FSSDNLTAIE EDPDANNLQI AVTRIKKGIN
1000
1001
YVKQTLREFI LKAFSKKPKI SREIRQAEDL NTKKENYISN HTLAEMSKGH
1050
1051
NFLKEKDKIS GFGSSVDKHL MEDSDGQSFI HNPSLTVTVP IAPGESDLEN
1100
1101
MNAEELSSDS DSEYSKVRLN RSSSSECSTV DNPLPGEGEE AEAEPMNSDE
1150
1151
PEACFTDGCV WRFSCCQVNI ESGKGKIWWN IRKTCYKIVE HSWFESFIVL
1200
1201
MILLSSGALA FEDIYIERKK TIKIILEYAD KIFTYIFILE MLLKWIAYGY
1250
1251
KTYFTNAWCW LDFLIVDVSL VTLVANTLGY SDLGPIKSLR TLRALRPLRA
1300
1301
LSRFEGMRVV VNALIGAIPS IMNVLLVCLI FWLIFSIMGV NLFAGKFYEC
1350
1351
INTTDGSRFP ASQVPNRSEC FALMNVSQNV RWKNLKVNFD NVGLGYLSLL
1400
1401
QVATFKGWTI IMYAAVDSVN VDKQPKYEYS LYMYIYFVVF IIFGSFFTLN
1450
1451
LFIGVIIDNF NQQKKKLGGQ DIFMTEEQKK YYNAMKKLGS KKPQKPIPRP
1500
1501
GNKIQGCIFD LVTNQAFDIS IMVLICLNMV TMMVEKEGQS QHMTEVLYWI
1550
1551
NVVFIILFTG ECVLKLISLR HYYFTVGWNI FDFVVVIISI VGMFLADLIE
1600
1601
TYFVSPTLFR VIRLARIGRI LRLVKGAKGI RTLLFALMMS LPALFNIGLL
1650
1651
LFLVMFIYAI FGMSNFAYVK KEDGINDMFN FETFGNSMIC LFQITTSAGW
1700
1701
DGLLAPILNS KPPDCDPKKV HPGSSVEGDC GNPSVGIFYF VSYIIISFLV
1750
1751
VVNMYIAVIL ENFSVATEES TEPLSEDDFE MFYEVWEKFD PDATQFIEFS
1800
1801
KLSDFAAALD PPLLIAKPNK VQLIAMDLPM VSGDRIHCLD ILFAFTKRVL
1850
1851
GESGEMDSLR SQMEERFMSA NPSKVSYEPI TTTLKRKQED VSATVIQRAY
1900
1901
RRYRLRQNVK NISSIYIKDG DRDDDLLNKK DMAFDNVNEN SSPEKTDATS
1950
1951
STTSPPSYDS VTKPDKEKYE QDRTEKEDKG KDSKESKK             
1988
 

Show the unformatted sequence.

Checksums:
CRC64:1BAEB8F32EBF5438
MD5:9b6f352d643a01295758bc2978c8b074

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Ion_trans 1191 - 1468 6J8G A 1191 - 1468 Show 3D Structure View in InterPro
6J8H A 1191 - 1468 Show 3D Structure View in InterPro
6J8I A 1191 - 1468 Show 3D Structure View in InterPro
6J8J A 1191 - 1468 Show 3D Structure View in InterPro
125 - 412 6J8G A 125 - 412 Show 3D Structure View in InterPro
6J8H A 125 - 412 Show 3D Structure View in InterPro
6J8I A 125 - 412 Show 3D Structure View in InterPro
6J8J A 125 - 412 Show 3D Structure View in InterPro
1514 - 1631 6NT3 A 1169 - 1286 Show 3D Structure View in InterPro
6NT4 A 1169 - 1286 Show 3D Structure View in InterPro
1514 - 1768 6J8G A 1514 - 1768 Show 3D Structure View in InterPro
6J8H A 1514 - 1768 Show 3D Structure View in InterPro
6J8I A 1514 - 1768 Show 3D Structure View in InterPro
6J8J A 1514 - 1768 Show 3D Structure View in InterPro
1529 - 1624 5EK0 A 1518 - 1613 Show 3D Structure View in InterPro
B 1518 - 1613 Show 3D Structure View in InterPro
C 1518 - 1613 Show 3D Structure View in InterPro
D 1518 - 1613 Show 3D Structure View in InterPro
257 - 275 6NT3 A 270 - 288 Show 3D Structure View in InterPro
6NT4 A 270 - 288 Show 3D Structure View in InterPro
743 - 972 6J8G A 743 - 972 Show 3D Structure View in InterPro
6J8H A 743 - 972 Show 3D Structure View in InterPro
6J8I A 743 - 972 Show 3D Structure View in InterPro
6J8J A 743 - 972 Show 3D Structure View in InterPro
751 - 841 7K48 A 740 - 829 Show 3D Structure View in InterPro
B 740 - 829 Show 3D Structure View in InterPro
C 740 - 829 Show 3D Structure View in InterPro
D 740 - 829 Show 3D Structure View in InterPro
758 - 843 6N4Q A 747 - 831 Show 3D Structure View in InterPro
B 747 - 831 Show 3D Structure View in InterPro
C 747 - 831 Show 3D Structure View in InterPro
D 747 - 831 Show 3D Structure View in InterPro
6N4R A 747 - 831 Show 3D Structure View in InterPro
B 747 - 831 Show 3D Structure View in InterPro
C 747 - 831 Show 3D Structure View in InterPro
D 747 - 831 Show 3D Structure View in InterPro
817 - 835 6VXO A 98 - 116 Show 3D Structure View in InterPro
C 98 - 116 Show 3D Structure View in InterPro
D 98 - 116 Show 3D Structure View in InterPro
E 98 - 116 Show 3D Structure View in InterPro
6W6O A 98 - 116 Show 3D Structure View in InterPro
D 98 - 116 Show 3D Structure View in InterPro
F 98 - 116 Show 3D Structure View in InterPro
H 98 - 116 Show 3D Structure View in InterPro
Na_trans_assoc 1175 - 1187 6J8G A 1175 - 1187 Show 3D Structure View in InterPro
6J8H A 1175 - 1187 Show 3D Structure View in InterPro
6J8I A 1175 - 1187 Show 3D Structure View in InterPro
6J8J A 1175 - 1187 Show 3D Structure View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;