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13  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: SMN_HUMAN (Q16637)

Summary

This is the summary of UniProt entry SMN_HUMAN (Q16637).

Description: Survival motor neuron protein
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 294 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
disorder n/a 1 26
low_complexity n/a 4 11
Pfam SMN 26 293
disorder n/a 61 86
low_complexity n/a 65 88
disorder n/a 141 231
low_complexity n/a 147 166
coiled_coil n/a 149 169
low_complexity n/a 194 212
low_complexity n/a 205 235
low_complexity n/a 234 251
disorder n/a 242 256
disorder n/a 283 284
disorder n/a 287 294

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q16637. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MAMSSGGSGG GVPEQEDSVL FRRGTGQSDD SDIWDDTALI KAYDKAVASF
50
51
KHALKNGDIC ETSGKPKTTP KRKPAKKNKS QKKNTAASLQ QWKVGDKCSA
100
101
IWSEDGCIYP ATIASIDFKR ETCVVVYTGY GNREEQNLSD LLSPICEVAN
150
151
NIEQNAQENE NESQVSTDES ENSRSPGNKS DNIKPKSAPW NSFLPPPPPM
200
201
PGPRLGPGKP GLKFNGPPPP PPPPPPHLLS CWLPPFPSGP PIIPPPPPIC
250
251
PDSLDDADAL GSMLISWYMS GYHTGYYMGF RQNQKEGRCS HSLN      
294
 

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Checksums:
CRC64:8A9A2A94192DCB9B
MD5:3c8efcbb3e5ae62a71ef6e996240eb45

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
SMN 26 - 51 2LEH B 26 - 51 Show 3D Structure View in InterPro
263 - 281 4GLI A 370 - 388 Show 3D Structure View in InterPro
35 - 51 5XJL M 35 - 51 Show 3D Structure View in InterPro
5XJQ M 35 - 51 Show 3D Structure View in InterPro
5XJS M 35 - 51 Show 3D Structure View in InterPro
5XJT M 35 - 51 Show 3D Structure View in InterPro
35 - 52 5XJR M 35 - 52 Show 3D Structure View in InterPro
5XJU M 35 - 52 Show 3D Structure View in InterPro
84 - 147 4A4E A 84 - 147 Show 3D Structure View in InterPro
4A4G A 84 - 147 Show 3D Structure View in InterPro
89 - 147 1MHN A 89 - 147 Show 3D Structure View in InterPro
90 - 145 1G5V A 90 - 145 Show 3D Structure View in InterPro
90 - 147 4QQ6 A 90 - 147 Show 3D Structure View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;