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15  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: CAS1_ECOLI (Q46896)

Summary

This is the summary of UniProt entry CAS1_ECOLI (Q46896).

Description: CRISPR-associated endonuclease Cas1 EC=3.1.-.-
Source organism: Escherichia coli (strain K12) (NCBI taxonomy ID 83333)
Length: 305 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
Pfam Cas_Cas1 123 244
low_complexity n/a 193 205
disorder n/a 278 279
disorder n/a 283 285
disorder n/a 288 289

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q46896. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MTWLPLNPIP LKDRVSMIFL QYGQIDVIDG AFVLIDKTGI RTHIPVGSVA
50
51
CIMLEPGTRV SHAAVRLAAQ VGTLLVWVGE AGVRVYASGQ PGGARSDKLL
100
101
YQAKLALDED LRLKVVRKMF ELRFGEPAPA RRSVEQLRGI EGSRVRATYA
150
151
LLAKQYGVTW NGRRYDPKDW EKGDTINQCI SAATSCLYGV TEAAILAAGY
200
201
APAIGFVHTG KPLSFVYDIA DIIKFDTVVP KAFEIARRNP GEPDREVRLA
250
251
CRDIFRSSKT LAKLIPLIED VLAAGEIQPP APPEDAQPVA IPLPVSLGDA
300
301
GHRSS                                                 
305
 

Show the unformatted sequence.

Checksums:
CRC64:01A31BA98453D8A5
MD5:af7302e3205daf5bbe4f76dc4289bd08

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Cas_Cas1 123 - 236 4QDL C 123 - 236 Show 3D Structure View in InterPro
123 - 244 3NKD A 123 - 244 Show 3D Structure View in InterPro
B 123 - 244 Show 3D Structure View in InterPro
3NKE A 123 - 244 Show 3D Structure View in InterPro
B 123 - 244 Show 3D Structure View in InterPro
C 123 - 244 Show 3D Structure View in InterPro
4P6I C 123 - 244 Show 3D Structure View in InterPro
D 123 - 244 Show 3D Structure View in InterPro
E 123 - 244 Show 3D Structure View in InterPro
F 123 - 244 Show 3D Structure View in InterPro
4QDL A 123 - 244 Show 3D Structure View in InterPro
B 123 - 244 Show 3D Structure View in InterPro
D 123 - 244 Show 3D Structure View in InterPro
5DLJ A 123 - 244 Show 3D Structure View in InterPro
B 123 - 244 Show 3D Structure View in InterPro
C 123 - 244 Show 3D Structure View in InterPro
D 123 - 244 Show 3D Structure View in InterPro
5DQT A 123 - 244 Show 3D Structure View in InterPro
B 123 - 244 Show 3D Structure View in InterPro
C 123 - 244 Show 3D Structure View in InterPro
D 123 - 244 Show 3D Structure View in InterPro
I 123 - 244 Show 3D Structure View in InterPro
J 123 - 244 Show 3D Structure View in InterPro
K 123 - 244 Show 3D Structure View in InterPro
L 123 - 244 Show 3D Structure View in InterPro
5DQU A 123 - 244 Show 3D Structure View in InterPro
B 123 - 244 Show 3D Structure View in InterPro
C 123 - 244 Show 3D Structure View in InterPro
D 123 - 244 Show 3D Structure View in InterPro
5DQZ A 123 - 244 Show 3D Structure View in InterPro
B 123 - 244 Show 3D Structure View in InterPro
C 123 - 244 Show 3D Structure View in InterPro
D 123 - 244 Show 3D Structure View in InterPro
5DS4 A 123 - 244 Show 3D Structure View in InterPro
B 123 - 244 Show 3D Structure View in InterPro
C 123 - 244 Show 3D Structure View in InterPro
D 123 - 244 Show 3D Structure View in InterPro
5DS5 A 123 - 244 Show 3D Structure View in InterPro
B 123 - 244 Show 3D Structure View in InterPro
C 123 - 244 Show 3D Structure View in InterPro
D 123 - 244 Show 3D Structure View in InterPro
5DS6 A 123 - 244 Show 3D Structure View in InterPro
B 123 - 244 Show 3D Structure View in InterPro
C 123 - 244 Show 3D Structure View in InterPro
D 123 - 244 Show 3D Structure View in InterPro
5VVJ A 123 - 244 Show 3D Structure View in InterPro
B 123 - 244 Show 3D Structure View in InterPro
C 123 - 244 Show 3D Structure View in InterPro
D 123 - 244 Show 3D Structure View in InterPro
5VVK A 123 - 244 Show 3D Structure View in InterPro
B 123 - 244 Show 3D Structure View in InterPro
C 123 - 244 Show 3D Structure View in InterPro
D 123 - 244 Show 3D Structure View in InterPro
5VVL A 123 - 244 Show 3D Structure View in InterPro
B 123 - 244 Show 3D Structure View in InterPro
C 123 - 244 Show 3D Structure View in InterPro
D 123 - 244 Show 3D Structure View in InterPro
5WFE A 123 - 244 Show 3D Structure View in InterPro
B 123 - 244 Show 3D Structure View in InterPro
C 123 - 244 Show 3D Structure View in InterPro
D 123 - 244 Show 3D Structure View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;