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1  structure 1  species 0  interactions 1  sequence 1  architecture

Protein: ARO1_CANAL (Q5AME2)

Summary

This is the summary of UniProt entry ARO1_CANAL (Q5AME2).

Description: Pentafunctional AROM polypeptide {ECO:0000255|HAMAP-Rule:MF_03143} 3-dehydroquinate synthase {ECO:0000255|HAMAP-Rule:MF_03143} 3-phosphoshikimate 1-carboxyvinyltransferase {ECO:0000255|HAMAP-Rule:MF_03143} Shikimate kinase {ECO:0000255|HAMAP-Rule:MF_03143} 3-dehydroquinate dehydratase {ECO:0000255|HAMAP-Rule:MF_03143} Shikimate dehydrogenase {ECO:0000255|HAMAP-Rule:MF_03143}
Source organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) (NCBI taxonomy ID 237561)
Length: 1551 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
disorder n/a 56 59
Pfam DHQ_synthase 73 354
disorder n/a 73 74
Pfam EPSP_synthase 397 832
disorder n/a 403 404
disorder n/a 464 466
disorder n/a 519 521
disorder n/a 686 708
low_complexity n/a 688 695
low_complexity n/a 719 734
low_complexity n/a 768 779
Pfam SKI 867 1031
Pfam DHquinase_I 1046 1263
low_complexity n/a 1122 1132
Pfam Shikimate_dh_N 1276 1357
Pfam Shikimate_DH 1381 1484
Pfam SDH_C 1519 1549

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q5AME2. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MSIEKVPILG KETIHVGYGI ADHIVREVIA NLASSTYVIV TDTNMARTPQ
50
51
YSKLTDDFKT NLSEKRPESR LLTYCVSPGE NNKNRATKAA VEDFLLQQGC
100
101
TRDTVILAVG GGVIGDMIGF VAATFMRGVR VVQVPTTLLA MVDSSVGGKT
150
151
AIDTPLGKNF IGAFHQPEYV FCDVSFLETL PARQFINGMA EVVKTAAIWN
200
201
EEEFTRLENF SKKFLSVVTS KKPDLQSIKA ELVKTVLESV RVKAGVVSSD
250
251
EKEAGLRNLL NFGHTIGHAI EAVLTPEALH GECVSIGMIK EAELSRYLGI
300
301
LPPVAVARLS KCLVAYGLPV SIDDKEFLKK VGPKRHYVEI DILLKKMAID
350
351
KKNDGSKIRC VLLEKIGKCY QLKAHQVSKQ DLSFVLTDEV LVHPFTNPPK
400
401
ENIIVPPGSK SISNRALILA ALGNGTVRVK NLLHSDDTKH MLDAVASLKG
450
451
AEISTEDNGE TIVVKGNGGN LVTSGEELYL GNAGTASRFL TTVASLVGKS
500
501
QASDDVILTG NARMQERPIG PLVDALGSNG SEIEYLNKQG SLPLKISAGN
550
551
GLKGGRIELA ATISSQYVSS ILMCAPYAKE PVTLALVGGK PISQLYIDMT
600
601
CAMMKSFGIE VTKSTTEEYT YHIPKGTYKN PSEYVIESDA SSATYPLAFA
650
651
AMTGTSCTIP NIGSSSLQGD AKFAVDVLKP MGCKVEQTTT STTVTGPPRG
700
701
HLKPLPHVDM EPMTDAFLTA SVVAAVAKGG SSTSITGIAN QRVKECNRIE
750
751
AMVTELAKFG VPANELPDGI EIHGIDIEDL KTPEISKRGV SSYDDHRVAM
800
801
SFSLLAGLCK EPVLILERST TGKTWPGWWD ILHSKFKIEL DGYEPPFNTD
850
851
KHVDKSSDKS IIVIGMRGTG KSTLSEWLAS FLGFKMLDMD KYLEEKLGTG
900
901
IKSLIKAKGW EYFRQEEAIV AKECFTKFSK GYVLSTGGGI VEGEDARQQL
950
951
KSYADNGGIV LHLHRDLDET VTFLAADTTR PAYSSEVQEV WLRREKWYHE
1000
1001
CSNYHFYSSH CSTEDEFNHL RRSFVNYIKL ITGAERPVVP AGRSAAVVLT
1050
1051
SPDLNEVVGD LESITIGADA VELRVDLFKD TSAEFVAAQI AVIRKHADLP
1100
1101
IIYTVRTVSQ GGKFPDENVD ELKSLLLLGI RLGVAYVDLQ LTAPNELIEE
1150
1151
ISSKKGFTRV IGTYQDINGE LKWNNVEWKN KYNQGVSMNA DIVRLVGKAN
1200
1201
SIQDNLDLEN FKKQNTLKPL IAFNLGSQGK LSQVLNGTFT PISHKLLPND
1250
1251
EEFLTIGELN QTYFDIGGFT AKKFWVIGSP IEHSRSPNLH NAGYKALNLP
1300
1301
YQFGRFEATD VDVVYDNLIN KPDFGGLAIT MPLKLDIMKF ATKLSDAAET
1350
1351
IGAVNTLIPI EGGYFGDNTD WVGISNSFIR AGVPPKSSSN GLVVGAGGTS
1400
1401
RAAIYALHQM GCAKIYLVNR TAAKLEELVK SFPKDYNLEI VETEQQADKA
1450
1451
SKVSLAVSCI PADKPLDGEV LKKIERILSN GSEQSAGFKP TLLEASYKPR
1500
1501
VTPIMKLTEE QYKWKVIPGV EMLVNQGDRQ FKLHTGFTAP YEIIHRAVVE
1550
1551
E                                                     
1551
 

Show the unformatted sequence.

Checksums:
CRC64:310DB8A3B63A81C8
MD5:5dd0d6d92fd0b6fcd52738e1641c2c1e

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
DHQ_synthase 73 - 348 6C5C B 73 - 348 Show 3D Structure View in InterPro
73 - 354 6C5C A 73 - 354 Show 3D Structure View in InterPro
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The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;