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0  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: IRAG2_DANRE (Q5RHB5)

Summary

This is the summary of UniProt entry IRAG2_DANRE (Q5RHB5).

Description: Inositol 1,4,5-triphosphate receptor associated 2
Source organism: Danio rerio (Zebrafish) (Brachydanio rerio) (NCBI taxonomy ID 7955)
Length: 1447 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
disorder n/a 1 24
disorder n/a 26 43
disorder n/a 45 47
disorder n/a 55 98
disorder n/a 101 103
low_complexity n/a 105 117
disorder n/a 115 133
disorder n/a 144 166
Pfam EF-hand_9 230 295
disorder n/a 302 303
disorder n/a 305 316
disorder n/a 339 341
Pfam KASH_CCD 347 537
coiled_coil n/a 356 404
disorder n/a 370 394
disorder n/a 397 403
low_complexity n/a 399 422
disorder n/a 405 408
disorder n/a 415 438
coiled_coil n/a 422 484
low_complexity n/a 424 442
disorder n/a 446 448
disorder n/a 461 465
coiled_coil n/a 492 512
disorder n/a 528 531
disorder n/a 533 536
disorder n/a 642 655
coiled_coil n/a 671 726
disorder n/a 700 701
disorder n/a 703 704
low_complexity n/a 707 719
disorder n/a 710 748
disorder n/a 751 1134
Pfam MRVI1 950 1360
low_complexity n/a 988 1005
low_complexity n/a 1153 1169
disorder n/a 1162 1164
disorder n/a 1196 1197
disorder n/a 1220 1224
disorder n/a 1226 1227
coiled_coil n/a 1243 1263
disorder n/a 1257 1259
disorder n/a 1261 1289
disorder n/a 1291 1295
disorder n/a 1310 1333
disorder n/a 1356 1379
Pfam MRVI1 1375 1447
transmembrane n/a 1389 1411
low_complexity n/a 1393 1411

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q5RHB5. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MDVGVTPRRH NPVDSICRKL QTIQRRDQEI NSPFQIPKFQ TNSYDSPHSG
50
51
LRFNLEAILK KHTVRPDDSD SASSAGMLTP TASPGPGSSC NTPRAPITPV
100
101
NATYSITSTL GTLGTIGDRR TSGTYSRPFR RNCSTPSAQT GDNYFNFTPR
150
151
YSTQSQGPDT DVRTSKIPTP GLFSYNLNFS SDISNMDSEL AYPALVVKRL
200
201
SLGEGSLFTS EPKKESMAEV SLICEEDLLD TIFQACDTQC RGKVYVSHIV
250
251
DFLRHTTCRS SEDSGLEELC NMLDPERKDI SIDLDTYHAI MKEWIEDCRN
300
301
QGKDLKNDTQ QESSKLRDSL SAKRSALLNM TSGSLEAFGG EASRADLETS
350
351
DLVFCVADLQ LNNQKLQEEV RKLKQAVENM EDTNQKLIEE NEELKTQAKM
400
401
GQQLLQKEKM LKEEVEEMKL SLTSSEESRA QAAAQRKQME RENQSLISKI
450
451
AALQEENMKV TLEAEELQKK MNDLCDLNAD LQVQIHSFDA ILADKESLIQ
500
501
EKNKQMDELK VAVVEYSSVT ELLRADKNKL ESQMQMMQPD VTIPGLSLSV
550
551
AYRLNQTSSG SLQTELALAQ NPLEGLEHLS TSVCFASSLD ETLDREVLLL
600
601
LQGPTPEQLS LEFKSLISRL KREFKEDGLT FLTAIRSLTE NSETQEANTD
650
651
LKMQGLEVQL EQRRTDWIRS LEQLDQYRDS LERELLKMAS NMRRSRTEIL
700
701
HLSVKVQEQE NQKQQLREEV DRLKTPLDNR EASSQTPDHL QQVVEELDGP
750
751
SLEWDEEYVL SESPPLQELG PDQQMLEELC CDEEVLQALK QEEEEPTETV
800
801
SDKEKITAKS EGEGEATYDS GVENEEPQRD FTLSHMCLPD KKSERESNEA
850
851
PFVGEGGEQR PCMSLKEEDR LPECTGPEDA HEQAAPLPHT HCECAGDQPL
900
901
TYDNLEVTSV KDHILSTEPS SLMTCELVSP STGHPEVGNS ITGRTEQLVG
950
951
TNGEPEEERL TTGADMSDLQ RLGEGQLSKV SAKSDKSLLL PVAEEEEAMP
1000
1001
EAVEVTSAGV NSPDKHKTGS KKTVVTSDSN STGSADSLKD PSEKVKDMTF
1050
1051
DPAASEDNIP TVPATQSPKK DPLASRNKLK KEMSSMEVIE EQKAQEDGEP
1100
1101
TVVTEKEGDT SVSSENASDS TKDDKNSLSP SDKEIEAEFH RLSLGFKCDM
1150
1151
FTLEKRLRLE ERSRDLAEEN VRKEVISCKA LLQALIPRCE EDNQSMEIIH
1200
1201
RVQKNLEILV QSMTRVSSRS EMLGAIHQET RVGKTVEVMI QHVENLRRMY
1250
1251
TKEHAELLEL RENLTPNERS FGSHSERDDF RNKKQTTSNI FKTTSRRISI
1300
1301
ATIPRSIGGQ THFDMPKDMA ETEVERLSRR SPWNMAAKRP PLKRFVSSGT
1350
1351
WADIDEPTLM NSPTPSPTDN APPSLMEGRP AVSRGARGIW IWVALFVVLA
1400
1401
VLLALLASLM LQPAVDAAPV GTGDSWMTIQ QLLWPYTGLR HNGQPPV   
1447
 

Show the unformatted sequence.

Checksums:
CRC64:A21A1ADEFD72CF35
MD5:7a2c03280182db0c1b14b052e160e9dd

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;