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0  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: S4A10_HUMAN (Q6U841)

Summary

This is the summary of UniProt entry S4A10_HUMAN (Q6U841).

Description: Sodium-driven chloride bicarbonate exchanger {ECO:0000303|PubMed:10993873}
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 1118 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
disorder n/a 1 37
low_complexity n/a 57 79
disorder n/a 59 91
disorder n/a 94 101
disorder n/a 103 106
disorder n/a 112 113
Pfam Band_3_cyto 146 435
disorder n/a 192 193
disorder n/a 196 197
disorder n/a 199 200
disorder n/a 202 230
disorder n/a 239 276
disorder n/a 279 322
disorder n/a 437 474
Pfam HCO3_cotransp 481 989
transmembrane n/a 510 532
transmembrane n/a 539 558
transmembrane n/a 597 620
transmembrane n/a 627 645
transmembrane n/a 725 743
transmembrane n/a 763 781
transmembrane n/a 811 830
transmembrane n/a 851 875
transmembrane n/a 911 933
transmembrane n/a 983 1000
transmembrane n/a 1006 1023
low_complexity n/a 1041 1055
coiled_coil n/a 1044 1064
disorder n/a 1045 1059
low_complexity n/a 1104 1118
disorder n/a 1106 1118

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q6U841. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MEIKDQGAQM EPLLPTRNDE EAVVDRGGTR SILKTHFEKE DLEGHRTLFI
50
51
GVHVPLGGRK SHRRHRHRGH KHRKRDRERD SGLEDGRESP SFDTPSQRVQ
100
101
FILGTEDDDE EHIPHDLFTE LDEICWREGE DAEWRETARW LKFEEDVEDG
150
151
GERWSKPYVA TLSLHSLFEL RSCILNGTVL LDMHANTLEE IADMVLDQQV
200
201
SSGQLNEDVR HRVHEALMKQ HHHQNQKKLT NRIPIVRSFA DIGKKQSEPN
250
251
SMDKNAGQVV SPQSAPACVE NKNDVSRENS TVDFSKGLGG QQKGHTSPCG
300
301
MKQRHEKGPP HQQEREVDLH FMKKIPPGAE ASNILVGELE FLDRTVVAFV
350
351
RLSPAVLLQG LAEVPIPTRF LFILLGPLGK GQQYHEIGRS IATLMTDEVF
400
401
HDVAYKAKDR NDLVSGIDEF LDQVTVLPPG EWDPSIRIEP PKNVPSQEKR
450
451
KIPAVPNGTA AHGEAEPHGG HSGPELQRTG RIFGGLILDI KRKAPYFWSD
500
501
FRDAFSLQCL ASFLFLYCAC MSPVITFGGL LGEATEGRIS AIESLFGASM
550
551
TGIAYSLFGG QPLTILGSTG PVLVFEKILF KFCKEYGLSY LSLRASIGLW
600
601
TATLCIILVA TDASSLVCYI TRFTEEAFAS LICIIFIYEA LEKLFELSEA
650
651
YPINMHNDLE LLTQYSCNCV EPHNPSNGTL KEWRESNISA SDIIWENLTV
700
701
SECKSLHGEY VGRACGHDHP YVPDVLFWSV ILFFSTVTLS ATLKQFKTSR
750
751
YFPTKVRSIV SDFAVFLTIL CMVLIDYAIG IPSPKLQVPS VFKPTRDDRG
800
801
WFVTPLGPNP WWTVIAAIIP ALLCTILIFM DQQITAVIIN RKEHKLKKGC
850
851
GYHLDLLMVA VMLGVCSIMG LPWFVAATVL SITHVNSLKL ESECSAPGEQ
900
901
PKFLGIREQR VTGLMIFILM GSSVFMTSIL KFIPMPVLYG VFLYMGASSL
950
951
KGIQFFDRIK LFWMPAKHQP DFIYLRHVPL RKVHLFTIIQ MSCLGLLWII
1000
1001
KVSRAAIVFP MMVLALVFVR KLMDLLFTKR ELSWLDDLMP ESKKKKLEDA
1050
1051
EKEEEQSMLA MEDEGTVQLP LEGHYRDDPS VINISDEMSK TALWRNLLIT
1100
1101
ADNSKDKESS FPSKSSPS                                   
1118
 

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Checksums:
CRC64:2376529C2CBE04E2
MD5:c70d74bcdd9630750589871ccc98a82d

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;