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4  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: ZCCHV_HUMAN (Q7Z2W4)

Summary

This is the summary of UniProt entry ZCCHV_HUMAN (Q7Z2W4).

Description: Zinc finger CCCH-type antiviral protein 1
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 902 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
Pfam HTH_53 5 66
low_complexity n/a 61 75
Pfam zf-CCCH_8 143 170
disorder n/a 216 249
disorder n/a 254 256
disorder n/a 258 260
disorder n/a 265 288
disorder n/a 290 353
disorder n/a 359 404
disorder n/a 407 410
disorder n/a 412 435
disorder n/a 439 477
disorder n/a 479 481
low_complexity n/a 489 509
disorder n/a 490 492
disorder n/a 497 501
Pfam WWE 607 682
disorder n/a 622 624
disorder n/a 701 702
disorder n/a 705 708
Pfam PARP 737 895
low_complexity n/a 755 763

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q7Z2W4. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MADPEVCCFI TKILCAHGGR MALDALLQEI ALSEPQLCEV LQVAGPDRFV
50
51
VLETGGEAGI TRSVVATTRA RVCRRKYCQR PCDNLHLCKL NLLGRCNYSQ
100
101
SERNLCKYSH EVLSEENFKV LKNHELSGLN KEELAVLLLQ SDPFFMPEIC
150
151
KSYKGEGRQQ ICNQQPPCSR LHICDHFTRG NCRFPNCLRS HNLMDRKVLA
200
201
IMREHGLNPD VVQNIQDICN SKHMQKNPPG PRAPSSHRRN MAYRARSKSR
250
251
DRFFQGSQEF LASASASAER SCTPSPDQIS HRASLEDAPV DDLTRKFTYL
300
301
GSQDRARPPS GSSKATDLGG TSQAGTSQRF LENGSQEDLL HGNPGSTYLA
350
351
SNSTSAPNWK SLTSWTNDQG ARRKTVFSPT LPAARSSLGS LQTPEAVTTR
400
401
KGTGLLSSDY RIINGKSGTQ DIQPGPLFNN NADGVATDIT STRSLNYKST
450
451
SSGHREISSP RIQDAGPASR DVQATGRIAD DADPRVALVN DSLSDVTSTT
500
501
SSRVDDHDSE EICLDHLCKG CPLNGSCSKV HFHLPYRWQM LIGKTWTDFE
550
551
HMETIEKGYC NPGIHLCSVG SYTINFRVMS CDSFPIRRLS TPSSVTKPAN
600
601
SVFTTKWIWY WKNESGTWIQ YGEEKDKRKN SNVDSSYLES LYQSCPRGVV
650
651
PFQAGSRNYE LSFQGMIQTN IASKTQKDVI RRPTFVPQWY VQQMKRGPDH
700
701
QPAKTSSVSL TATFRPQEDF CFLSSKKYKL SEIHHLHPEY VRVSEHFKAS
750
751
MKNFKIEKIK KIENSELLDK FTWKKSQMKE EGKLLFYATS RAYVESICSN
800
801
NFDSFLHETH ENKYGKGIYF AKDAIYSHKN CPYDAKNVVM FVAQVLVGKF
850
851
TEGNITYTSP PPQFDSCVDT RSNPSVFVIF QKDQVYPQYV IEYTEDKACV
900
901
IS                                                    
902
 

Show the unformatted sequence.

Checksums:
CRC64:72AB311D23658E24
MD5:c39ab97f2ccd8eb3cce858a9209a1966

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
HTH_53 5 - 66 6UEI A 5 - 66 Show 3D Structure View in InterPro
6UEJ A 5 - 66 Show 3D Structure View in InterPro
PARP 737 - 895 2X5Y A 737 - 895 Show 3D Structure View in InterPro
4X52 A 737 - 895 Show 3D Structure View in InterPro
B 737 - 895 Show 3D Structure View in InterPro
C 737 - 895 Show 3D Structure View in InterPro
D 737 - 895 Show 3D Structure View in InterPro
zf-CCCH_8 143 - 170 6UEI A 143 - 170 Show 3D Structure View in InterPro
6UEJ A 143 - 170 Show 3D Structure View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;