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5  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: TAF8_HUMAN (Q7Z7C8)

Summary

This is the summary of UniProt entry TAF8_HUMAN (Q7Z7C8).

Description: Transcription initiation factor TFIID subunit 8
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 310 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
disorder n/a 3 29
low_complexity n/a 4 19
Pfam Bromo_TP 29 106
disorder n/a 77 83
disorder n/a 115 162
Pfam TAF8_C 145 193
disorder n/a 170 178
coiled_coil n/a 172 192
disorder n/a 180 181
disorder n/a 185 193
disorder n/a 195 197
disorder n/a 230 297
low_complexity n/a 296 307
disorder n/a 300 303
disorder n/a 305 307
disorder n/a 309 310

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q7Z7C8. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MADAAATAGA GGSGTRSGSK QSTNPADNYH LARRRTLQVV VSSLLTEAGF
50
51
ESAEKASVET LTEMLQSYIS EIGRSAKSYC EHTARTQPTL SDIVVTLVEM
100
101
GFNVDTLPAY AKRSQRMVIT APPVTNQPVT PKALTAGQNR PHPPHIPSHF
150
151
PEFPDPHTYI KTPTYREPVS DYQVLREKAA SQRRDVERAL TRFMAKTGET
200
201
QSLFKDDVST FPLIAARPFT IPYLTALLPS ELEMQQMEET DSSEQDEQTD
250
251
TENLALHISM EDSGAEKENT SVLQQNPSLS GSRNGEENII DNPYLRPVKK
300
301
PKIRRKKSLS                                            
310
 

Show the unformatted sequence.

Checksums:
CRC64:0F955828FE9FC0EA
MD5:67e8bcca3a3b3278235f6d1a37f353ef

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Bromo_TP 29 - 106 4WV4 B 29 - 106 NGL View in InterPro
6MZC K 29 - 106 NGL View in InterPro
6MZL K 29 - 106 NGL View in InterPro
6MZM K 29 - 106 NGL View in InterPro
TAF8_C 145 - 193 6MZC K 145 - 193 NGL View in InterPro
6MZL K 145 - 193 NGL View in InterPro
6MZM K 145 - 193 NGL View in InterPro
172 - 193 5FUR L 172 - 193 NGL View in InterPro
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The parts of the structure corresponding to the Pfam family are highlighted in yellow.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;