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0  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: CORA1_HUMAN (Q8IZC6)

Summary

This is the summary of UniProt entry CORA1_HUMAN (Q8IZC6).

Description: Collagen alpha-1(XXVII) chain
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 1860 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
low_complexity n/a 2 22
disorder n/a 243 248
disorder n/a 276 1631
low_complexity n/a 433 457
low_complexity n/a 481 506
low_complexity n/a 572 588
low_complexity n/a 599 610
Pfam Collagen 624 685
low_complexity n/a 625 679
Pfam Collagen 681 746
low_complexity n/a 694 706
low_complexity n/a 714 734
low_complexity n/a 799 832
Pfam Collagen 823 898
Pfam Collagen 873 938
Pfam Collagen 892 954
low_complexity n/a 900 925
Pfam Collagen 922 1007
low_complexity n/a 927 946
low_complexity n/a 943 961
low_complexity n/a 1012 1030
low_complexity n/a 1023 1060
low_complexity n/a 1053 1075
Pfam Collagen 1075 1145
low_complexity n/a 1084 1099
low_complexity n/a 1108 1129
low_complexity n/a 1125 1153
Pfam Collagen 1170 1247
low_complexity n/a 1221 1243
Pfam Collagen 1225 1289
low_complexity n/a 1267 1288
Pfam Collagen 1279 1339
low_complexity n/a 1314 1340
Pfam Collagen 1338 1399
low_complexity n/a 1340 1367
low_complexity n/a 1376 1400
low_complexity n/a 1399 1418
low_complexity n/a 1448 1472
Pfam Collagen 1508 1583
Pfam Collagen 1562 1623
low_complexity n/a 1571 1593
low_complexity n/a 1601 1621
disorder n/a 1633 1636
disorder n/a 1647 1650
Pfam COLFI 1658 1743
Pfam COLFI 1738 1859
disorder n/a 1836 1838

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q8IZC6. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MGAGSARGAR GTAAAAAARG GGFLFSWILV SFACHLASTQ GAPEDVDILQ
50
51
RLGLSWTKAG SPAPPGVIPF QSGFIFTQRA RLQAPTGTVI PAALGTELAL
100
101
VLSLCSHRVN HAFLFAVRSQ KRKLQLGLQF LPGKTVVHLG SRRSVAFDLD
150
151
MHDGRWHHLA LELRGRTVTL VTACGQRRVP VLLPFHRDPA LDPGGSFLFG
200
201
KMNPHAVQFE GALCQFSIYP VTQVAHNYCT HLRKQCGQAD TYQSPLGPLF
250
251
SQDSGRPFTF QSDLALLGLE NLTTATPALG SLPAGRGPRG TVAPATPTKP
300
301
QRTSPTNPHQ HMAVGGPAQT PLLPAKLSAS NALDPMLPAS VGGSTRTPRP
350
351
AAAQPSQKIT ATKIPKSLPT KPSAPSTSIV PIKSPHPTQK TAPSSFTKSA
400
401
LPTQKQVPPT SRPVPARVSR PAEKPIQRNP GMPRPPPPST RPLPPTTSSS
450
451
KKPIPTLART EAKITSHASK PASARTSTHK PPPFTALSSS PAPTPGSTRS
500
501
TRPPATMVPP TSGTSTPRTA PAVPTPGSAP TGSKKPIGSE ASKKAGPKSS
550
551
PRKPVPLRPG KAARDVPLSD LTTRPSPRQP QPSQQTTPAL VLAPAQFLSS
600
601
SPRPTSSGYS IFHLAGSTPF PLLMGPPGPK GDCGLPGPPG LPGLPGIPGA
650
651
RGPRGPPGPY GNPGLPGPPG AKGQKGDPGL SPGKAHDGAK GDMGLPGLSG
700
701
NPGPPGRKGH KGYPGPAGHP GEQGQPGPEG SPGAKGYPGR QGLPGPVGDP
750
751
GPKGSRGYIG LPGLFGLPGS DGERGLPGVP GKRGKMGMPG FPGVFGERGP
800
801
PGLDGNPGEL GLPGPPGVPG LIGDLGVLGP IGYPGPKGMK GLMGSVGEPG
850
851
LKGDKGEQGV PGVSGDPGFQ GDKGSQGLPG FPGARGKPGP LGKVGDKGSI
900
901
GFPGPPGPEG FPGDIGPPGD NGPEGMKGKP GARGLPGPRG QLGPEGDEGP
950
951
MGPPGAPGLE GQPGRKGFPG RPGLDGVKGE PGDPGRPGPV GEQGFMGFIG
1000
1001
LVGEPGIVGE KGDRGMMGPP GVPGPKGSMG HPGMPGGMGT PGEPGPQGPP
1050
1051
GSRGPPGMRG AKGRRGPRGP DGPAGEQGSR GLKGPPGPQG RPGRPGQQGV
1100
1101
AGERGHLGSR GFPGIPGPSG PPGTKGLPGE PGPQGPQGPI GPPGEMGPKG
1150
1151
PPGAVGEPGL PGEAGMKGDL GPLGTPGEQG LIGQRGEPGL EGDSGPMGPD
1200
1201
GLKGDRGDPG PDGEHGEKGQ EGLMGEDGPP GPPGVTGVRG PEGKSGKQGE
1250
1251
KGRTGAKGAK GYQGQLGEMG VPGDPGPPGT PGPKGSRGSL GPTGAPGRMG
1300
1301
AQGEPGLAGY DGHKGIVGPL GPPGPKGEKG EQGEDGKAEG PPGPPGDRGP
1350
1351
VGDRGDRGEP GDPGYPGQEG VQGLRGKPGQ QGQPGHPGPR GWPGPKGSKG
1400
1401
AEGPKGKQGK AGAPGRRGVQ GLQGLPGPRG VVGRQGLEGI AGPDGLPGRD
1450
1451
GQAGQQGEQG DDGDPGPMGP AGKRGNPGVA GLPGAQGPPG FKGESGLPGQ
1500
1501
LGPPGKRGTE GRTGLPGNQG EPGSKGQPGD SGEMGFPGMA GLFGPKGPPG
1550
1551
DIGFKGIQGP RGPPGLMGKE GIVGPLGILG PSGLPGPKGD KGSRGDWGLQ
1600
1601
GPRGPPGPRG RPGPPGPPGG PIQLQQDDLG AAFQTWMDTS GALRPESYSY
1650
1651
PDRLVLDQGG EIFKTLHYLS NLIQSIKTPL GTKENPARVC RDLMDCEQKM
1700
1701
VDGTYWVDPN LGCSSDTIEV SCNFTHGGQT CLKPITASKV EFAISRVQMN
1750
1751
FLHLLSSEVT QHITIHCLNM TVWQEGTGQT PAKQAVRFRA WNGQIFEAGG
1800
1801
QFRPEVSMDG CKVQDGRWHQ TLFTFRTQDP QQLPIISVDN LPPASSGKQY
1850
1851
RLEVGPACFL                                            
1860
 

Show the unformatted sequence.

Checksums:
CRC64:5F8CDFAF4B6014EC
MD5:521582a5b7ef0de6cd89a7902b609329

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;