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1  structure 1  species 0  interactions 1  sequence 1  architecture

Protein: RYBP_HUMAN (Q8N488)

Summary

This is the summary of UniProt entry RYBP_HUMAN (Q8N488).

Description: RING1 and YY1-binding protein
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 228 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
disorder n/a 1 20
Pfam zf-RanBP 22 48
disorder n/a 43 45
disorder n/a 49 228
low_complexity n/a 63 76
low_complexity n/a 73 97
low_complexity n/a 103 114
Pfam YAF2_RYBP 145 177
low_complexity n/a 177 190
low_complexity n/a 189 205
low_complexity n/a 199 214

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q8N488. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MTMGDKKSPT RPKRQAKPAA DEGFWDCSVC TFRNSAEAFK CSICDVRKGT
50
51
STRKPRINSQ LVAQQVAQQY ATPPPPKKEK KEKVEKQDKE KPEKDKEISP
100
101
SVTKKNTNKK TKPKSDILKD PPSEANSIQS ANATTKTSET NHTSRPRLKN
150
151
VDRSTAQQLA VTVGNVTVII TDFKEKTRSS STSSSTVTSS AGSEQQNQSS
200
201
SGSESTDKGS SRSSTPKGDM SAVNDESF                        
228
 

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Checksums:
CRC64:EB9593460A3F0F4C
MD5:feeb0ed7e8d9d82d58e3578c1ae7fcee

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
YAF2_RYBP 145 - 176 3IXS D 145 - 176 NGL View in InterPro
F 145 - 176 NGL View in InterPro
L 145 - 176 NGL View in InterPro
145 - 177 3IXS H 145 - 177 NGL View in InterPro
146 - 176 3IXS B 146 - 176 NGL View in InterPro
147 - 176 3IXS J 147 - 176 NGL View in InterPro
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The parts of the structure corresponding to the Pfam family are highlighted in yellow.

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TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.