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0  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: KASH5_HUMAN (Q8N6L0)

Summary

This is the summary of UniProt entry KASH5_HUMAN (Q8N6L0).

Description: Protein KASH5 {ECO:0000305}
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 562 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
disorder n/a 1 24
disorder n/a 27 29
Pfam EF-hand_9 38 105
disorder n/a 39 41
disorder n/a 71 90
disorder n/a 121 123
disorder n/a 125 164
Pfam KASH_CCD 157 347
low_complexity n/a 161 172
coiled_coil n/a 166 186
disorder n/a 177 178
disorder n/a 180 192
disorder n/a 194 196
disorder n/a 201 202
disorder n/a 215 220
coiled_coil n/a 218 294
disorder n/a 228 232
disorder n/a 239 251
disorder n/a 253 265
disorder n/a 267 279
disorder n/a 281 284
coiled_coil n/a 316 343
disorder n/a 320 321
disorder n/a 340 342
disorder n/a 344 357
disorder n/a 359 362
disorder n/a 379 384
low_complexity n/a 402 413
disorder n/a 407 488
low_complexity n/a 474 485
low_complexity n/a 521 547
transmembrane n/a 522 542

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q8N6L0. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MDLPEGPVGG PTAEMYLRER PEEARLGMPV SLEEQILNST FEACDPQRTG
50
51
TVAVAQVLAY LEAVTGQGPQ DARLQTLANS LDPNGEGPKA TVDLDTFLVV
100
101
MRDWIAACQL HGGLELEEET AFQGALTSRQ LPSGCPEAEE PANLESFGGE
150
151
DPRPELQATA DLLSSLEDLE LSNRRLVGEN AKLQRSMETA EEGSARLGEE
200
201
ILALRKQLHS TQQALQFAKA MDEELEDLKT LARSLEEQNR SLLAQARQAE
250
251
KEQQHLVAEM ETLQEENGKL LAERDGVKKR SQELAMEKDT LKRQLFECEH
300
301
LICQRDTILS ERTRDVESLA QTLEEYRVTT QELRLEISRL EEQLSQTYEG
350
351
PDELPEGAQL RRVGWTELLP PSLGLEIEAI RQKQEVATAD LSNPLCGVWQ
400
401
WEEVIHETSE ETEFPSEAPA GGQRNFQGEP AHPEEGRKEP SMWLTRREEE
450
451
EDAESQVTAD LPVPLGAPRP GDIPENPPER PARRELQQAL VPVMKKLVPV
500
501
RRRAWGQLCL PPQRLRVTRH PLIPAPVLGL LLLLLLSVLL LGPSPPPTWP
550
551
HLQLCYLQPP PV                                         
562
 

Show the unformatted sequence.

Checksums:
CRC64:39F47D3F236A9918
MD5:a201d817fa9cc7bb153fc1d1a917fe2c

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;