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0  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: ZIC4_HUMAN (Q8N9L1)

Summary

This is the summary of UniProt entry ZIC4_HUMAN (Q8N9L1).

Description: Zinc finger protein ZIC 4
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 334 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
disorder n/a 14 15
disorder n/a 18 60
low_complexity n/a 54 69
disorder n/a 73 86
low_complexity n/a 83 94
Pfam zf_ZIC 121 166
low_complexity n/a 152 163
disorder n/a 159 160
Pfam zf-C2H2 204 228
disorder n/a 249 254
disorder n/a 256 259
Pfam zf-C2H2 264 288
disorder n/a 282 304
disorder n/a 309 313
disorder n/a 317 334
low_complexity n/a 319 327

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q8N9L1. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MRYKTSLVMR KRLRLYRNTL KESSSSSGHH GPQLTAASSP SVFPGLHEEP
50
51
PQASPSRPLN GLLRLGLPGD MYARPEPFPP GPAARSDALA AAAALHGYGG
100
101
MNLTVNLAAP HGPGAFFRYM RQPIKQELIC KWLAADGTAT PSLCSKTFST
150
151
MHELVTHVTV EHVGGPEQAN HICFWEECPR QGKPFKAKYK LVNHIRVHTG
200
201
EKPFPCPFPG CGKVFARSEN LKIHKRTHTG EKPFRCEFEG CERRFANSSD
250
251
RKKHSHVHTS DKPYTCKVRG CDKCYTHPSS LRKHMKVHGR SPPPSSGYDS
300
301
ATPSALVSPS SDCGHKSQVA SSAAVAARTA DLSE                 
334
 

Show the unformatted sequence.

Checksums:
CRC64:9EFEA2447D7B2F64
MD5:a0b6955b17f2bd567aa574e2f1c19ead

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;