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0  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: DEN6B_HUMAN (Q8NEG7)

Summary

This is the summary of UniProt entry DEN6B_HUMAN (Q8NEG7).

Description: Protein DENND6B
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 585 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
low_complexity n/a 26 37
Pfam Avl9 42 181
disorder n/a 223 224
Pfam SPA 248 358
low_complexity n/a 265 278
disorder n/a 362 363
disorder n/a 368 369

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q8NEG7. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MDALLGTGPR RARGCLGAAG PTSSGRAART PAAPWARFSA WLECVCVVTF
50
51
DLELGQALEL VYPNDFRLTD KEKSSICYLS FPDSHSGCLG DTQFSFRMRQ
100
101
CGGQRSPWHA DDRHYNSRAP VALQREPAHY FGYVYFRQVK DSSVKRGYFQ
150
151
KSLVLVSRLP FVRLFQALLS LIAPEYFDKL APCLEAVCSE IDQWPAPAPG
200
201
QTLNLPVMGV VVQVRIPSRV DKSESSPPKQ FDQENLLPAP VVLASVHELD
250
251
LFRCFRPVLT HMQTLWELML LGEPLLVLAP SPDVSSEMVL ALTSCLQPLR
300
301
FCCDFRPYFT IHDSEFKEFT TRTQAPPNVV LGVTNPFFIK TLQHWPHILR
350
351
VGEPKMSGDL PKQVKLKKPS RLKTLDTKPG LYTAYTAHLH RDKALLKRLL
400
401
KGVQKKRPSD VQSALLRRHL LELTQSFIIP LEHYMASLMP LQKSITPWKT
450
451
PPQIQPFSQD DFLRSLEHAG PQLTCILKGD WLGLYRRFFK SPHFDGWYRQ
500
501
RHKEMALKLE ALHLEAICEA NIETWMKDKS EVEVVDLVLK LREKLVRAQG
550
551
HQLPVKEATL QRAQLYIETV IGSLPKDLQA VLCPP                
585
 

Show the unformatted sequence.

Checksums:
CRC64:2B2D5F46647D448C
MD5:74354e88c7e403cfb9667eeb5047c12a

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;