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3  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: FLCN_HUMAN (Q8NFG4)

Summary

This is the summary of UniProt entry FLCN_HUMAN (Q8NFG4).

Description: Folliculin {ECO:0000303|PubMed:15657874}
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 579 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
disorder n/a 24 76
low_complexity n/a 40 51
Pfam Folliculin 104 265
disorder n/a 284 288
coiled_coil n/a 289 309
low_complexity n/a 293 308
disorder n/a 294 326
Pfam Folliculin_C 344 566
disorder n/a 568 570
disorder n/a 572 579

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q8NFG4. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MNAIVALCHF CELHGPRTLF CTEVLHAPLP QGDGNEDSPG QGEQAEEEEG
50
51
GIQMNSRMRA HSPAEGASVE SSSPGPKKSD MCEGCRSLAA GHPGYISHDK
100
101
ETSIKYVSHQ HPSHPQLFSI VRQACVRSLS CEVCPGREGP IFFGDEQHGF
150
151
VFSHTFFIKD SLARGFQRWY SIITIMMDRI YLINSWPFLL GKVRGIIDEL
200
201
QGKALKVFEA EQFGCPQRAQ RMNTAFTPFL HQRNGNAARS LTSLTSDDNL
250
251
WACLHTSFAW LLKACGSRLT EKLLEGAPTE DTLVQMEKLA DLEEESESWD
300
301
NSEAEEEEKA PVLPESTEGR ELTQGPAESS SLSGCGSWQP RKLPVFKSLR
350
351
HMRQVLGAPS FRMLAWHVLM GNQVIWKSRD VDLVQSAFEV LRTMLPVGCV
400
401
RIIPYSSQYE EAYRCNFLGL SPHVQIPPHV LSSEFAVIVE VHAAARSTLH
450
451
PVGCEDDQSL SKYEFVVTSG SPVAADRVGP TILNKIEAAL TNQNLSVDVV
500
501
DQCLVCLKEE WMNKVKVLFK FTKVDSRPKE DTQKLLSILG ASEEDNVKLL
550
551
KFWMTGLSKT YKSHLMSTVR SPTASESRN                       
579
 

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Checksums:
CRC64:E168EB34544C6336
MD5:4a2f1be9be9b1f918128b01437f9d873

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Folliculin 104 - 265 6NZD H 104 - 265 NGL View in InterPro
6ULG L 104 - 265 NGL View in InterPro
Folliculin_C 344 - 558 3V42 A 344 - 558 NGL View in InterPro
B 344 - 558 NGL View in InterPro
6NZD H 344 - 558 NGL View in InterPro
344 - 566 6ULG L 344 - 566 NGL View in InterPro
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TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.