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1  structure 1  species 0  interactions 1  sequence 1  architecture

Protein: NEIL3_HUMAN (Q8TAT5)

Summary

This is the summary of UniProt entry NEIL3_HUMAN (Q8TAT5).

Description: Endonuclease 8-like 3 EC=3.2.2.-
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 605 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
Pfam H2TH 153 231
Pfam zf-RanBP 317 346
disorder n/a 402 414
disorder n/a 423 448
disorder n/a 451 453
disorder n/a 456 468
disorder n/a 471 477
disorder n/a 490 502
Pfam zf-GRF 505 550
Pfam zf-GRF 552 596

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q8TAT5. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MVEGPGCTLN GEKIRARVLP GQAVTGVRGS ALRSLQGRAL RLAASTVVVS
50
51
PQAAALNNDS SQNVLSLFNG YVYSGVETLG KELFMYFGPK ALRIHFGMKG
100
101
FIMINPLEYK YKNGASPVLE VQLTKDLICF FDSSVELRNS MESQQRIRMM
150
151
KELDVCSPEF SFLRAESEVK KQKGRMLGDV LMDQNVLPGV GNIIKNEALF
200
201
DSGLHPAVKV CQLTDEQIHH LMKMIRDFSI LFYRCRKAGL ALSKHYKVYK
250
251
RPNCGQCHCR ITVCRFGDNN RMTYFCPHCQ KENPQHVDIC KLPTRNTIIS
300
301
WTSSRVDHVM DSVARKSEEH WTCVVCTLIN KPSSKACDAC LTSRPIDSVL
350
351
KSEENSTVFS HLMKYPCNTF GKPHTEVKIN RKTAFGTTTL VLTDFSNKSS
400
401
TLERKTKQNQ ILDEEFQNSP PASVCLNDIQ HPSKKTTNDI TQPSSKVNIS
450
451
PTISSESKLF SPAHKKPKTA QYSSPELKSC NPGYSNSELQ INMTDGPRTL
500
501
NPDSPRCSKH NRLCILRVVG KDGENKGRQF YACPLPREAQ CGFFEWADLS
550
551
FPFCNHGKRS TMKTVLKIGP NNGKNFFVCP LGKEKQCNFF QWAENGPGIK
600
601
IIPGC                                                 
605
 

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Checksums:
CRC64:528B17873ABC9D89
MD5:47d3be36cfb1b1ea1916527b417d6b44

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
zf-GRF 505 - 550 7JL5 A 505 - 550 NGL View in InterPro
B 505 - 550 NGL View in InterPro
552 - 593 7JL5 A 552 - 593 NGL View in InterPro
552 - 594 7JL5 B 552 - 594 NGL View in InterPro
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The parts of the structure corresponding to the Pfam family are highlighted in yellow.

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TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.