Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
3  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: PUM2_HUMAN (Q8TB72)

Summary

This is the summary of UniProt entry PUM2_HUMAN (Q8TB72).

Description: Pumilio homolog 2
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 1066 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

Show or hide the data used to generate the graphic in JSON format.

Source Domain Start End
disorder n/a 19 27
disorder n/a 30 33
disorder n/a 35 40
disorder n/a 49 86
disorder n/a 91 99
disorder n/a 103 104
disorder n/a 106 244
disorder n/a 250 252
low_complexity n/a 270 291
disorder n/a 271 272
low_complexity n/a 325 342
disorder n/a 327 328
low_complexity n/a 359 384
disorder n/a 368 409
low_complexity n/a 396 420
disorder n/a 451 452
disorder n/a 457 461
low_complexity n/a 472 495
disorder n/a 493 526
low_complexity n/a 505 514
low_complexity n/a 526 540
disorder n/a 534 555
low_complexity n/a 564 592
disorder n/a 574 597
low_complexity n/a 587 602
disorder n/a 620 650
low_complexity n/a 630 660
disorder n/a 666 670
low_complexity n/a 675 693
disorder n/a 701 702
Pfam PUF 730 764
disorder n/a 745 747
Pfam PUF 767 799
Pfam PUF 802 837
Pfam PUF 840 872
Pfam PUF 876 910
Pfam PUF 912 946
Pfam PUF 948 982
Pfam PUF 992 1025
disorder n/a 1060 1061

Show or hide domain scores.

Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q8TB72. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MNHDFQALAL ESRGMGELLP TKKFWEPDDS TKDGQKGIFL GDDEWRETAW
50
51
GASHHSMSQP IMVQRRSGQG FHGNSEVNAI LSPRSESGGL GVSMVEYVLS
100
101
SSPADKLDSR FRKGNFGTRD AETDGPEKGD QKGKASPFEE DQNRDLKQGD
150
151
DDDSKINGRG LPNGMDADCK DFNRTPGSRQ ASPTEVVERL GPNTNPSEGL
200
201
GPLPNPTANK PLVEEFSNPE TQNLDAMEQV GLESLQFDYP GNQVPMDSSG
250
251
ATVGLFDYNS QQQLFQRTNA LTVQQLTAAQ QQQYALAAAQ QPHIAGVFSA
300
301
GLAPAAFVPN PYIISAAPPG TDPYTAAGLA AAATLAGPAV VPPQYYGVPW
350
351
GVYPANLFQQ QAAAAANNTA SQQAASQAQP GQQQVLRAGA GQRPLTPNQG
400
401
QQGQQAESLA AAAAANPTLA FGQGLATGMP GYQVLAPTAY YDQTGALVVG
450
451
PGARTGLGAP VRLMAPTPVL ISSAAAQAAA AAAAGGTASS LTGSTNGLFR
500
501
PIGTQPPQQQ QQQPSTNLQS NSFYGSSSLT NSSQSSSLFS HGPGQPGSTS
550
551
LGFGSGNSLG AAIGSALSGF GSSVGSSASS SATRRESLST SSDLYKRSSS
600
601
SLAPIGQPFY NSLGFSSSPS PIGMPLPSQT PGHSLTPPPS LSSHGSSSSL
650
651
HLGGLTNGSG RYISAAPGAE AKYRSASSTS SLFSSSSQLF PPSRLRYNRS
700
701
DIMPSGRSRL LEDFRNNRFP NLQLRDLIGH IVEFSQDQHG SRFIQQKLER
750
751
ATPAERQMVF NEILQAAYQL MTDVFGNYVI QKFFEFGSLD QKLALATRIR
800
801
GHVLPLALQM YGCRVIQKAL ESISSDQQVI SEMVKELDGH VLKCVKDQNG
850
851
NHVVQKCIEC VQPQSLQFII DAFKGQVFVL STHPYGCRVI QRILEHCTAE
900
901
QTLPILEELH QHTEQLVQDQ YGNYVIQHVL EHGRPEDKSK IVSEIRGKVL
950
951
ALSQHKFASN VVEKCVTHAS RAERALLIDE VCCQNDGPHS ALYTMMKDQY
1000
1001
ANYVVQKMID MAEPAQRKII MHKIRPHITT LRKYTYGKHI LAKLEKYYLK
1050
1051
NSPDLGPIGG PPNGML                                     
1066
 

Show the unformatted sequence.

Checksums:
CRC64:CF6F9D7998CD5D9E
MD5:2865040861998f11239d3fbbe05d8520

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
PUF 730 - 764 3Q0Q A 730 - 764 NGL View in InterPro
3Q0R A 730 - 764 NGL View in InterPro
3Q0S A 730 - 764 NGL View in InterPro
767 - 799 3Q0Q A 767 - 799 NGL View in InterPro
3Q0R A 767 - 799 NGL View in InterPro
3Q0S A 767 - 799 NGL View in InterPro
802 - 837 3Q0Q A 802 - 837 NGL View in InterPro
3Q0R A 802 - 837 NGL View in InterPro
3Q0S A 802 - 837 NGL View in InterPro
840 - 872 3Q0Q A 840 - 872 NGL View in InterPro
3Q0R A 840 - 872 NGL View in InterPro
3Q0S A 840 - 872 NGL View in InterPro
876 - 910 3Q0Q A 876 - 910 NGL View in InterPro
3Q0R A 876 - 910 NGL View in InterPro
3Q0S A 876 - 910 NGL View in InterPro
912 - 946 3Q0Q A 912 - 946 NGL View in InterPro
3Q0R A 912 - 946 NGL View in InterPro
3Q0S A 912 - 946 NGL View in InterPro
948 - 982 3Q0Q A 948 - 982 NGL View in InterPro
3Q0R A 948 - 982 NGL View in InterPro
3Q0S A 948 - 982 NGL View in InterPro
992 - 1025 3Q0Q A 992 - 1025 NGL View in InterPro
3Q0R A 992 - 1025 NGL View in InterPro
3Q0S A 992 - 1025 NGL View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in yellow.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;