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9  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: PRP31_HUMAN (Q8WWY3)

Summary

This is the summary of UniProt entry PRP31_HUMAN (Q8WWY3).

Description: U4/U6 small nuclear ribonucleoprotein Prp31
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 499 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
low_complexity n/a 4 38
disorder n/a 6 40
Pfam Nop 99 330
coiled_coil n/a 177 197
disorder n/a 178 183
low_complexity n/a 179 189
low_complexity n/a 287 298
disorder n/a 329 368
Pfam Prp31_C 337 465
low_complexity n/a 349 365
disorder n/a 370 371
disorder n/a 379 380
disorder n/a 399 400
disorder n/a 403 423
disorder n/a 435 441
disorder n/a 445 448
disorder n/a 465 466
disorder n/a 498 499

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q8WWY3. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MSLADELLAD LEEAAEEEEG GSYGEEEEEP AIEDVQEETQ LDLSGDSVKT
50
51
IAKLWDSKMF AEIMMKIEEY ISKQAKASEV MGPVEAAPEY RVIVDANNLT
100
101
VEIENELNII HKFIRDKYSK RFPELESLVP NALDYIRTVK ELGNSLDKCK
150
151
NNENLQQILT NATIMVVSVT ASTTQGQQLS EEELERLEEA CDMALELNAS
200
201
KHRIYEYVES RMSFIAPNLS IIIGASTAAK IMGVAGGLTN LSKMPACNIM
250
251
LLGAQRKTLS GFSSTSVLPH TGYIYHSDIV QSLPPDLRRK AARLVAAKCT
300
301
LAARVDSFHE STEGKVGYEL KDEIERKFDK WQEPPPVKQV KPLPAPLDGQ
350
351
RKKRGGRRYR KMKERLGLTE IRKQANRMSF GEIEEDAYQE DLGFSLGHLG
400
401
KSGSGRVRQT QVNEATKARI SKTLQRTLQK QSVVYGGKST IRDRSSGTAS
450
451
SVAFTPLQGL EIVNPQAAEK KVAEANQKYF SSMAEFLKVK GEKSGLMST 
499
 

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Checksums:
CRC64:7B50EC4C3393795C
MD5:95bbc7ff7f450fc26b23624e2bc7feb2

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Nop 99 - 330 2OZB B 99 - 330 Show 3D Structure View in InterPro
E 99 - 330 Show 3D Structure View in InterPro
3JCR J 99 - 330 Show 3D Structure View in InterPro
3SIU B 99 - 330 Show 3D Structure View in InterPro
E 99 - 330 Show 3D Structure View in InterPro
3SIV B 99 - 330 Show 3D Structure View in InterPro
E 99 - 330 Show 3D Structure View in InterPro
H 99 - 330 Show 3D Structure View in InterPro
K 99 - 330 Show 3D Structure View in InterPro
5O9Z H 99 - 330 Show 3D Structure View in InterPro
6AH0 L 99 - 330 Show 3D Structure View in InterPro
6AHD L 99 - 330 Show 3D Structure View in InterPro
6QW6 4C 99 - 330 Show 3D Structure View in InterPro
6QX9 4C 99 - 330 Show 3D Structure View in InterPro
Prp31_C 337 - 432 6AHD L 337 - 432 Show 3D Structure View in InterPro
337 - 448 5O9Z H 337 - 448 Show 3D Structure View in InterPro
341 - 390 6QW6 4C 341 - 390 Show 3D Structure View in InterPro
6QX9 4C 341 - 390 Show 3D Structure View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;