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5  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: EFGM_HUMAN (Q96RP9)

Summary

This is the summary of UniProt entry EFGM_HUMAN (Q96RP9).

Description: Elongation factor G, mitochondrial {ECO:0000255|HAMAP-Rule:MF_03061}
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 751 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
sig_p n/a 1 22
low_complexity n/a 2 19
Pfam GTP_EFTU 44 319
low_complexity n/a 137 151
disorder n/a 327 329
disorder n/a 339 343
Pfam GTP_EFTU_D2 366 432
Pfam EFG_III 446 520
disorder n/a 466 468
Pfam EFG_IV 521 642
Pfam EFG_C 644 731

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q96RP9. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MRLLGAAAVA ALGRGRAPAS LGWQRKQVNW KACRWSSSGV IPNEKIRNIG
50
51
ISAHIDSGKT TLTERVLYYT GRIAKMHEVK GKDGVGAVMD SMELERQRGI
100
101
TIQSAATYTM WKDVNINIID TPGHVDFTIE VERALRVLDG AVLVLCAVGG
150
151
VQCQTMTVNR QMKRYNVPFL TFINKLDRMG SNPARALQQM RSKLNHNAAF
200
201
MQIPMGLEGN FKGIVDLIEE RAIYFDGDFG QIVRYGEIPA ELRAAATDHR
250
251
QELIECVANS DEQLGEMFLE EKIPSISDLK LAIRRATLKR SFTPVFLGSA
300
301
LKNKGVQPLL DAVLEYLPNP SEVQNYAILN KEDDSKEKTK ILMNSSRDNS
350
351
HPFVGLAFKL EVGRFGQLTY VRSYQGELKK GDTIYNTRTR KKVRLQRLAR
400
401
MHADMMEDVE EVYAGDICAL FGIDCASGDT FTDKANSGLS MESIHVPDPV
450
451
ISIAMKPSNK NDLEKFSKGI GRFTREDPTF KVYFDTENKE TVISGMGELH
500
501
LEIYAQRLER EYGCPCITGK PKVAFRETIT APVPFDFTHK KQSGGAGQYG
550
551
KVIGVLEPLD PEDYTKLEFS DETFGSNIPK QFVPAVEKGF LDACEKGPLS
600
601
GHKLSGLRFV LQDGAHHMVD SNEISFIRAG EGALKQALAN ATLCILEPIM
650
651
AVEVVAPNEF QGQVIAGINR RHGVITGQDG VEDYFTLYAD VPLNDMFGYS
700
701
TELRSCTEGK GEYTMEYSRY QPCLPSTQED VINKYLEATG QLPVKKGKAK
750
751
N                                                     
751
 

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Checksums:
CRC64:5937FFB24A089E2E
MD5:2ca9e3a4eb991f2984a95777b773e29e

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
EFG_C 644 - 731 6VLZ v 644 - 731 Show 3D Structure View in InterPro
6VMI v 644 - 731 Show 3D Structure View in InterPro
6YDP BC 644 - 731 Show 3D Structure View in InterPro
6YDW BC 644 - 731 Show 3D Structure View in InterPro
7A5K r1 644 - 731 Show 3D Structure View in InterPro
EFG_III 446 - 520 6VLZ v 446 - 520 Show 3D Structure View in InterPro
6VMI v 446 - 520 Show 3D Structure View in InterPro
6YDP BC 446 - 520 Show 3D Structure View in InterPro
6YDW BC 446 - 520 Show 3D Structure View in InterPro
7A5K r1 446 - 520 Show 3D Structure View in InterPro
EFG_IV 521 - 642 6VLZ v 521 - 642 Show 3D Structure View in InterPro
6VMI v 521 - 642 Show 3D Structure View in InterPro
6YDP BC 521 - 642 Show 3D Structure View in InterPro
6YDW BC 521 - 642 Show 3D Structure View in InterPro
7A5K r1 521 - 642 Show 3D Structure View in InterPro
GTP_EFTU 44 - 319 6VLZ v 44 - 319 Show 3D Structure View in InterPro
6VMI v 44 - 319 Show 3D Structure View in InterPro
6YDP BC 44 - 319 Show 3D Structure View in InterPro
6YDW BC 44 - 319 Show 3D Structure View in InterPro
7A5K r1 44 - 319 Show 3D Structure View in InterPro
GTP_EFTU_D2 366 - 432 6VLZ v 366 - 432 Show 3D Structure View in InterPro
6VMI v 366 - 432 Show 3D Structure View in InterPro
6YDP BC 366 - 432 Show 3D Structure View in InterPro
6YDW BC 366 - 432 Show 3D Structure View in InterPro
7A5K r1 366 - 432 Show 3D Structure View in InterPro
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The parts of the structure corresponding to the Pfam family are highlighted in blue.

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TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;