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3  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: SCN2A_HUMAN (Q99250)

Summary

This is the summary of UniProt entry SCN2A_HUMAN (Q99250).

Description: Sodium channel protein type 2 subunit alpha
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 2005 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
disorder n/a 1 2
coiled_coil n/a 22 42
disorder n/a 28 54
transmembrane n/a 125 148
Pfam Ion_trans 128 436
transmembrane n/a 193 212
transmembrane n/a 224 245
transmembrane n/a 251 271
transmembrane n/a 401 428
coiled_coil n/a 425 470
low_complexity n/a 433 448
disorder n/a 437 440
disorder n/a 447 448
low_complexity n/a 450 471
disorder n/a 461 462
low_complexity n/a 484 520
disorder n/a 494 529
coiled_coil n/a 498 518
Pfam Na_trans_cytopl 558 709
disorder n/a 563 565
disorder n/a 578 581
disorder n/a 588 601
disorder n/a 604 636
disorder n/a 665 678
disorder n/a 680 682
transmembrane n/a 751 775
Pfam Ion_trans 758 993
transmembrane n/a 787 808
transmembrane n/a 828 849
low_complexity n/a 846 858
transmembrane n/a 870 898
low_complexity n/a 886 898
transmembrane n/a 928 948
transmembrane n/a 960 983
low_complexity n/a 971 993
Pfam Na_trans_assoc 997 1203
disorder n/a 1079 1080
disorder n/a 1118 1165
low_complexity n/a 1120 1133
low_complexity n/a 1150 1169
Pfam Ion_trans 1207 1483
transmembrane n/a 1209 1227
transmembrane n/a 1248 1270
transmembrane n/a 1276 1296
low_complexity n/a 1304 1319
transmembrane n/a 1325 1351
transmembrane n/a 1449 1473
Pfam Ion_trans 1530 1787
transmembrane n/a 1532 1550
transmembrane n/a 1562 1580
transmembrane n/a 1587 1612
transmembrane n/a 1618 1637
low_complexity n/a 1628 1640
transmembrane n/a 1649 1677
disorder n/a 1734 1741
low_complexity n/a 1750 1768
transmembrane n/a 1753 1776
disorder n/a 1877 1878
disorder n/a 1894 1898
disorder n/a 1943 2005
low_complexity n/a 1966 1974
low_complexity n/a 1980 1999

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q99250. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MAQSVLVPPG PDSFRFFTRE SLAAIEQRIA EEKAKRPKQE RKDEDDENGP
50
51
KPNSDLEAGK SLPFIYGDIP PEMVSVPLED LDPYYINKKT FIVLNKGKAI
100
101
SRFSATPALY ILTPFNPIRK LAIKILVHSL FNMLIMCTIL TNCVFMTMSN
150
151
PPDWTKNVEY TFTGIYTFES LIKILARGFC LEDFTFLRDP WNWLDFTVIT
200
201
FAYVTEFVDL GNVSALRTFR VLRALKTISV IPGLKTIVGA LIQSVKKLSD
250
251
VMILTVFCLS VFALIGLQLF MGNLRNKCLQ WPPDNSSFEI NITSFFNNSL
300
301
DGNGTTFNRT VSIFNWDEYI EDKSHFYFLE GQNDALLCGN SSDAGQCPEG
350
351
YICVKAGRNP NYGYTSFDTF SWAFLSLFRL MTQDFWENLY QLTLRAAGKT
400
401
YMIFFVLVIF LGSFYLINLI LAVVAMAYEE QNQATLEEAE QKEAEFQQML
450
451
EQLKKQQEEA QAAAAAASAE SRDFSGAGGI GVFSESSSVA SKLSSKSEKE
500
501
LKNRRKKKKQ KEQSGEEEKN DRVRKSESED SIRRKGFRFS LEGSRLTYEK
550
551
RFSSPHQSLL SIRGSLFSPR RNSRASLFSF RGRAKDIGSE NDFADDEHST
600
601
FEDNDSRRDS LFVPHRHGER RHSNVSQASR ASRVLPILPM NGKMHSAVDC
650
651
NGVVSLVGGP STLTSAGQLL PEGTTTETEI RKRRSSSYHV SMDLLEDPTS
700
701
RQRAMSIASI LTNTMEELEE SRQKCPPCWY KFANMCLIWD CCKPWLKVKH
750
751
LVNLVVMDPF VDLAITICIV LNTLFMAMEH YPMTEQFSSV LSVGNLVFTG
800
801
IFTAEMFLKI IAMDPYYYFQ EGWNIFDGFI VSLSLMELGL ANVEGLSVLR
850
851
SFRLLRVFKL AKSWPTLNML IKIIGNSVGA LGNLTLVLAI IVFIFAVVGM
900
901
QLFGKSYKEC VCKISNDCEL PRWHMHDFFH SFLIVFRVLC GEWIETMWDC
950
951
MEVAGQTMCL TVFMMVMVIG NLVVLNLFLA LLLSSFSSDN LAATDDDNEM
1000
1001
NNLQIAVGRM QKGIDFVKRK IREFIQKAFV RKQKALDEIK PLEDLNNKKD
1050
1051
SCISNHTTIE IGKDLNYLKD GNGTTSGIGS SVEKYVVDES DYMSFINNPS
1100
1101
LTVTVPIAVG ESDFENLNTE EFSSESDMEE SKEKLNATSS SEGSTVDIGA
1150
1151
PAEGEQPEVE PEESLEPEAC FTEDCVRKFK CCQISIEEGK GKLWWNLRKT
1200
1201
CYKIVEHNWF ETFIVFMILL SSGALAFEDI YIEQRKTIKT MLEYADKVFT
1250
1251
YIFILEMLLK WVAYGFQVYF TNAWCWLDFL IVDVSLVSLT ANALGYSELG
1300
1301
AIKSLRTLRA LRPLRALSRF EGMRVVVNAL LGAIPSIMNV LLVCLIFWLI
1350
1351
FSIMGVNLFA GKFYHCINYT TGEMFDVSVV NNYSECKALI ESNQTARWKN
1400
1401
VKVNFDNVGL GYLSLLQVAT FKGWMDIMYA AVDSRNVELQ PKYEDNLYMY
1450
1451
LYFVIFIIFG SFFTLNLFIG VIIDNFNQQK KKFGGQDIFM TEEQKKYYNA
1500
1501
MKKLGSKKPQ KPIPRPANKF QGMVFDFVTK QVFDISIMIL ICLNMVTMMV
1550
1551
ETDDQSQEMT NILYWINLVF IVLFTGECVL KLISLRYYYF TIGWNIFDFV
1600
1601
VVILSIVGMF LAELIEKYFV SPTLFRVIRL ARIGRILRLI KGAKGIRTLL
1650
1651
FALMMSLPAL FNIGLLLFLV MFIYAIFGMS NFAYVKREVG IDDMFNFETF
1700
1701
GNSMICLFQI TTSAGWDGLL APILNSGPPD CDPDKDHPGS SVKGDCGNPS
1750
1751
VGIFFFVSYI IISFLVVVNM YIAVILENFS VATEESAEPL SEDDFEMFYE
1800
1801
VWEKFDPDAT QFIEFAKLSD FADALDPPLL IAKPNKVQLI AMDLPMVSGD
1850
1851
RIHCLDILFA FTKRVLGESG EMDALRIQME ERFMASNPSK VSYEPITTTL
1900
1901
KRKQEEVSAI IIQRAYRRYL LKQKVKKVSS IYKKDKGKEC DGTPIKEDTL
1950
1951
IDKLNENSTP EKTDMTPSTT SPPSYDSVTK PEKEKFEKDK SEKEDKGKDI
2000
2001
RESKK                                                 
2005
 

Show the unformatted sequence.

Checksums:
CRC64:8A421AE6C7ED9A37
MD5:2815ef1029f3fd8edd5c0cdfb3f9ae46

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Ion_trans 1207 - 1483 6J8E A 1207 - 1483 Show 3D Structure View in InterPro
128 - 436 6J8E A 128 - 436 Show 3D Structure View in InterPro
1530 - 1785 6J8E A 1530 - 1785 Show 3D Structure View in InterPro
1777 - 1787 2KAV A 1777 - 1787 Show 3D Structure View in InterPro
758 - 987 6J8E A 758 - 987 Show 3D Structure View in InterPro
Na_trans_assoc 1102 - 1120 4RLY A 1114 - 1132 Show 3D Structure View in InterPro
1191 - 1203 6J8E A 1191 - 1203 Show 3D Structure View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;