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17  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: CDC5L_HUMAN (Q99459)

Summary

This is the summary of UniProt entry CDC5L_HUMAN (Q99459).

Description: Cell division cycle 5-like protein
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 802 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
Pfam Myb_DNA-bind_6 11 71
Pfam Myb_DNA-bind_6 63 119
low_complexity n/a 66 77
disorder n/a 108 184
coiled_coil n/a 142 162
low_complexity n/a 143 152
coiled_coil n/a 168 189
disorder n/a 193 204
disorder n/a 207 212
disorder n/a 219 222
coiled_coil n/a 225 245
disorder n/a 235 239
disorder n/a 245 276
low_complexity n/a 258 271
disorder n/a 278 283
disorder n/a 307 308
disorder n/a 313 338
disorder n/a 340 371
disorder n/a 373 481
Pfam Myb_Cef 404 655
disorder n/a 489 520
disorder n/a 522 563
disorder n/a 566 568
disorder n/a 591 594
disorder n/a 596 612
disorder n/a 616 618
disorder n/a 682 684
disorder n/a 693 698
disorder n/a 700 709
low_complexity n/a 706 718
disorder n/a 766 772
coiled_coil n/a 767 801
disorder n/a 774 776

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q99459. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MPRIMIKGGV WRNTEDEILK AAVMKYGKNQ WSRIASLLHR KSAKQCKARW
50
51
YEWLDPSIKK TEWSREEEEK LLHLAKLMPT QWRTIAPIIG RTAAQCLEHY
100
101
EFLLDKAAQR DNEEETTDDP RKLKPGEIDP NPETKPARPD PIDMDEDELE
150
151
MLSEARARLA NTQGKKAKRK AREKQLEEAR RLAALQKRRE LRAAGIEIQK
200
201
KRKRKRGVDY NAEIPFEKKP ALGFYDTSEE NYQALDADFR KLRQQDLDGE
250
251
LRSEKEGRDR KKDKQHLKRK KESDLPSAIL QTSGVSEFTK KRSKLVLPAP
300
301
QISDAELQEV VKVGQASEIA RQTAEESGIT NSASSTLLSE YNVTNNSVAL
350
351
RTPRTPASQD RILQEAQNLM ALTNVDTPLK GGLNTPLHES DFSGVTPQRQ
400
401
VVQTPNTVLS TPFRTPSNGA EGLTPRSGTT PKPVINSTPG RTPLRDKLNI
450
451
NPEDGMADYS DPSYVKQMER ESREHLRLGL LGLPAPKNDF EIVLPENAEK
500
501
ELEEREIDDT YIEDAADVDA RKQAIRDAER VKEMKRMHKA VQKDLPRPSE
550
551
VNETILRPLN VEPPLTDLQK SEELIKKEMI TMLHYDLLHH PYEPSGNKKG
600
601
KTVGFGTNNS EHITYLEHNP YEKFSKEELK KAQDVLVQEM EVVKQGMSHG
650
651
ELSSEAYNQV WEECYSQVLY LPGQSRYTRA NLASKKDRIE SLEKRLEINR
700
701
GHMTTEAKRA AKMEKKMKIL LGGYQSRAMG LMKQLNDLWD QIEQAHLELR
750
751
TFEELKKHED SAIPRRLECL KEDVQRQQER EKELQHRYAD LLLEKETLKS
800
801
KF                                                    
802
 

Show the unformatted sequence.

Checksums:
CRC64:3390F91EE7E79DA6
MD5:c59d26b9091141aed32c1647f69726d1

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Myb_Cef 502 - 629 5XJC L 502 - 629 Show 3D Structure View in InterPro
5YZG L 502 - 629 Show 3D Structure View in InterPro
5Z56 L 502 - 629 Show 3D Structure View in InterPro
5Z57 L 502 - 629 Show 3D Structure View in InterPro
6ICZ L 502 - 629 Show 3D Structure View in InterPro
6ID0 L 502 - 629 Show 3D Structure View in InterPro
6ID1 L 502 - 629 Show 3D Structure View in InterPro
516 - 650 6QDV O 516 - 650 Show 3D Structure View in InterPro
Myb_DNA-bind_6 11 - 55 7ABH L 11 - 55 Show 3D Structure View in InterPro
11 - 63 2DIM A 12 - 64 Show 3D Structure View in InterPro
11 - 71 5MQF L 11 - 71 Show 3D Structure View in InterPro
5XJC L 11 - 71 Show 3D Structure View in InterPro
5YZG L 11 - 71 Show 3D Structure View in InterPro
5Z56 L 11 - 71 Show 3D Structure View in InterPro
5Z57 L 11 - 71 Show 3D Structure View in InterPro
5Z58 L 11 - 71 Show 3D Structure View in InterPro
6FF4 L 11 - 71 Show 3D Structure View in InterPro
6FF7 L 11 - 71 Show 3D Structure View in InterPro
6ICZ L 11 - 71 Show 3D Structure View in InterPro
6ID0 L 11 - 71 Show 3D Structure View in InterPro
6ID1 L 11 - 71 Show 3D Structure View in InterPro
6QDV O 11 - 71 Show 3D Structure View in InterPro
6ZYM L 11 - 71 Show 3D Structure View in InterPro
7AAV L 11 - 71 Show 3D Structure View in InterPro
59 - 71 2DIN A 8 - 20 Show 3D Structure View in InterPro
63 - 108 5XJC L 63 - 108 Show 3D Structure View in InterPro
5YZG L 63 - 108 Show 3D Structure View in InterPro
5Z56 L 63 - 108 Show 3D Structure View in InterPro
5Z57 L 63 - 108 Show 3D Structure View in InterPro
5Z58 L 63 - 108 Show 3D Structure View in InterPro
6ICZ L 63 - 108 Show 3D Structure View in InterPro
63 - 109 6QDV O 63 - 109 Show 3D Structure View in InterPro
63 - 110 6FF4 L 63 - 110 Show 3D Structure View in InterPro
6FF7 L 63 - 110 Show 3D Structure View in InterPro
7AAV L 63 - 110 Show 3D Structure View in InterPro
63 - 111 2DIN A 12 - 60 Show 3D Structure View in InterPro
5MQF L 63 - 111 Show 3D Structure View in InterPro
6ZYM L 63 - 111 Show 3D Structure View in InterPro
63 - 119 6ID0 L 63 - 119 Show 3D Structure View in InterPro
6ID1 L 63 - 119 Show 3D Structure View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;