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30  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: PSMD1_HUMAN (Q99460)

Summary

This is the summary of UniProt entry PSMD1_HUMAN (Q99460).

Description: 26S proteasome non-ATPase regulatory subunit 1
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 953 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
disorder n/a 279 316
disorder n/a 319 322
Pfam PC_rep 441 474
Pfam PC_rep 476 510
low_complexity n/a 476 489
low_complexity n/a 506 522
Pfam PC_rep 511 545
Pfam HEAT_2 599 692
transmembrane n/a 769 791
Pfam RPN2_C 786 925
low_complexity n/a 818 828
coiled_coil n/a 832 869
low_complexity n/a 837 872
disorder n/a 839 882
disorder n/a 888 891
disorder n/a 922 953
low_complexity n/a 936 949

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q99460. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MITSAAGIIS LLDEDEPQLK EFALHKLNAV VNDFWAEISE SVDKIEVLYE
50
51
DEGFRSRQFA ALVASKVFYH LGAFEESLNY ALGAGDLFNV NDNSEYVETI
100
101
IAKCIDHYTK QCVENADLPE GEKKPIDQRL EGIVNKMFQR CLDDHKYKQA
150
151
IGIALETRRL DVFEKTILES NDVPGMLAYS LKLCMSLMQN KQFRNKVLRV
200
201
LVKIYMNLEK PDFINVCQCL IFLDDPQAVS DILEKLVKED NLLMAYQICF
250
251
DLYESASQQF LSSVIQNLRT VGTPIASVPG STNTGTVPGS EKDSDSMETE
300
301
EKTSSAFVGK TPEASPEPKD QTLKMIKILS GEMAIELHLQ FLIRNNNTDL
350
351
MILKNTKDAV RNSVCHTATV IANSFMHCGT TSDQFLRDNL EWLARATNWA
400
401
KFTATASLGV IHKGHEKEAL QLMATYLPKD TSPGSAYQEG GGLYALGLIH
450
451
ANHGGDIIDY LLNQLKNASN DIVRHGGSLG LGLAAMGTAR QDVYDLLKTN
500
501
LYQDDAVTGE AAGLALGLVM LGSKNAQAIE DMVGYAQETQ HEKILRGLAV
550
551
GIALVMYGRM EEADALIESL CRDKDPILRR SGMYTVAMAY CGSGNNKAIR
600
601
RLLHVAVSDV NDDVRRAAVE SLGFILFRTP EQCPSVVSLL SESYNPHVRY
650
651
GAAMALGICC AGTGNKEAIN LLEPMTNDPV NYVRQGALIA SALIMIQQTE
700
701
ITCPKVNQFR QLYSKVINDK HDDVMAKFGA ILAQGILDAG GHNVTISLQS
750
751
RTGHTHMPSV VGVLVFTQFW FWFPLSHFLS LAYTPTCVIG LNKDLKMPKV
800
801
QYKSNCKPST FAYPAPLEVP KEKEKEKVST AVLSITAKAK KKEKEKEKKE
850
851
EEKMEVDEAE KKEEKEKKKE PEPNFQLLDN PARVMPAQLK VLTMPETCRY
900
901
QPFKPLSIGG IIILKDTSED IEELVEPVAA HGPKIEEEEQ EPEPPEPFEY
950
951
IDD                                                   
953
 

Show the unformatted sequence.

Checksums:
CRC64:B8682146082D21FA
MD5:567bfb4e382d493a72185d0aa30e6232

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
HEAT_2 599 - 692 5GJQ N 599 - 692 NGL View in InterPro
5GJR 1 599 - 692 NGL View in InterPro
N 599 - 692 NGL View in InterPro
5L4K N 599 - 692 NGL View in InterPro
5LN3 N 599 - 692 NGL View in InterPro
5M32 i 599 - 692 NGL View in InterPro
5T0C AU 599 - 692 NGL View in InterPro
BU 599 - 692 NGL View in InterPro
5T0G U 599 - 692 NGL View in InterPro
5T0H U 599 - 692 NGL View in InterPro
5T0I U 599 - 692 NGL View in InterPro
5T0J U 599 - 692 NGL View in InterPro
5VFP U 599 - 692 NGL View in InterPro
5VFQ U 599 - 692 NGL View in InterPro
5VFR U 599 - 692 NGL View in InterPro
5VFS U 599 - 692 NGL View in InterPro
5VFT U 599 - 692 NGL View in InterPro
5VFU U 599 - 692 NGL View in InterPro
5VGZ U 599 - 692 NGL View in InterPro
5VHF U 599 - 692 NGL View in InterPro
5VHH U 599 - 692 NGL View in InterPro
5VHI U 599 - 692 NGL View in InterPro
5VHS U 599 - 692 NGL View in InterPro
6MSB U 599 - 692 NGL View in InterPro
6MSD U 599 - 692 NGL View in InterPro
6MSE U 599 - 692 NGL View in InterPro
6MSG U 599 - 692 NGL View in InterPro
6MSH U 599 - 692 NGL View in InterPro
6MSJ U 599 - 692 NGL View in InterPro
6MSK U 599 - 692 NGL View in InterPro
6WJD U 599 - 692 NGL View in InterPro
6WJN U 599 - 692 NGL View in InterPro
PC_rep 441 - 474 5GJQ N 441 - 474 NGL View in InterPro
5GJR 1 441 - 474 NGL View in InterPro
N 441 - 474 NGL View in InterPro
5L4K N 441 - 474 NGL View in InterPro
5LN3 N 441 - 474 NGL View in InterPro
5T0C AU 441 - 474 NGL View in InterPro
BU 441 - 474 NGL View in InterPro
5T0G U 441 - 474 NGL View in InterPro
5T0H U 441 - 474 NGL View in InterPro
5T0I U 441 - 474 NGL View in InterPro
5T0J U 441 - 474 NGL View in InterPro
5VFP U 441 - 474 NGL View in InterPro
5VFQ U 441 - 474 NGL View in InterPro
5VFR U 441 - 474 NGL View in InterPro
5VFS U 441 - 474 NGL View in InterPro
5VFT U 441 - 474 NGL View in InterPro
5VFU U 441 - 474 NGL View in InterPro
5VGZ U 441 - 474 NGL View in InterPro
5VHF U 441 - 474 NGL View in InterPro
5VHH U 441 - 474 NGL View in InterPro
5VHI U 441 - 474 NGL View in InterPro
5VHS U 441 - 474 NGL View in InterPro
6MSB U 441 - 474 NGL View in InterPro
6MSD U 441 - 474 NGL View in InterPro
6MSE U 441 - 474 NGL View in InterPro
6MSG U 441 - 474 NGL View in InterPro
6MSH U 441 - 474 NGL View in InterPro
6MSJ U 441 - 474 NGL View in InterPro
6MSK U 441 - 474 NGL View in InterPro
6WJD U 441 - 474 NGL View in InterPro
6WJN U 441 - 474 NGL View in InterPro
476 - 510 5GJQ N 476 - 510 NGL View in InterPro
5GJR 1 476 - 510 NGL View in InterPro
N 476 - 510 NGL View in InterPro
5L4K N 476 - 510 NGL View in InterPro
5LN3 N 476 - 510 NGL View in InterPro
5M32 i 476 - 510 NGL View in InterPro
5T0C AU 476 - 510 NGL View in InterPro
BU 476 - 510 NGL View in InterPro
5T0G U 476 - 510 NGL View in InterPro
5T0H U 476 - 510 NGL View in InterPro
5T0I U 476 - 510 NGL View in InterPro
5T0J U 476 - 510 NGL View in InterPro
5VFP U 476 - 510 NGL View in InterPro
5VFQ U 476 - 510 NGL View in InterPro
5VFR U 476 - 510 NGL View in InterPro
5VFS U 476 - 510 NGL View in InterPro
5VFT U 476 - 510 NGL View in InterPro
5VFU U 476 - 510 NGL View in InterPro
5VGZ U 476 - 510 NGL View in InterPro
5VHF U 476 - 510 NGL View in InterPro
5VHH U 476 - 510 NGL View in InterPro
5VHI U 476 - 510 NGL View in InterPro
5VHS U 476 - 510 NGL View in InterPro
6MSB U 476 - 510 NGL View in InterPro
6MSD U 476 - 510 NGL View in InterPro
6MSE U 476 - 510 NGL View in InterPro
6MSG U 476 - 510 NGL View in InterPro
6MSH U 476 - 510 NGL View in InterPro
6MSJ U 476 - 510 NGL View in InterPro
6MSK U 476 - 510 NGL View in InterPro
6WJD U 476 - 510 NGL View in InterPro
6WJN U 476 - 510 NGL View in InterPro
511 - 545 5GJQ N 511 - 545 NGL View in InterPro
5GJR 1 511 - 545 NGL View in InterPro
N 511 - 545 NGL View in InterPro
5L4K N 511 - 545 NGL View in InterPro
5LN3 N 511 - 545 NGL View in InterPro
5M32 i 511 - 545 NGL View in InterPro
5T0C AU 511 - 545 NGL View in InterPro
BU 511 - 545 NGL View in InterPro
5T0G U 511 - 545 NGL View in InterPro
5T0H U 511 - 545 NGL View in InterPro
5T0I U 511 - 545 NGL View in InterPro
5T0J U 511 - 545 NGL View in InterPro
5VFP U 511 - 545 NGL View in InterPro
5VFQ U 511 - 545 NGL View in InterPro
5VFR U 511 - 545 NGL View in InterPro
5VFS U 511 - 545 NGL View in InterPro
5VFT U 511 - 545 NGL View in InterPro
5VFU U 511 - 545 NGL View in InterPro
5VGZ U 511 - 545 NGL View in InterPro
5VHF U 511 - 545 NGL View in InterPro
5VHH U 511 - 545 NGL View in InterPro
5VHI U 511 - 545 NGL View in InterPro
5VHS U 511 - 545 NGL View in InterPro
6MSB U 511 - 545 NGL View in InterPro
6MSD U 511 - 545 NGL View in InterPro
6MSE U 511 - 545 NGL View in InterPro
6MSG U 511 - 545 NGL View in InterPro
6MSH U 511 - 545 NGL View in InterPro
6MSJ U 511 - 545 NGL View in InterPro
6MSK U 511 - 545 NGL View in InterPro
6WJD U 511 - 545 NGL View in InterPro
6WJN U 511 - 545 NGL View in InterPro
RPN2_C 786 - 917 5T0C AU 786 - 917 NGL View in InterPro
BU 786 - 917 NGL View in InterPro
5T0G U 786 - 917 NGL View in InterPro
5T0H U 786 - 917 NGL View in InterPro
5T0I U 786 - 917 NGL View in InterPro
5T0J U 786 - 917 NGL View in InterPro
5VFP U 786 - 917 NGL View in InterPro
5VFQ U 786 - 917 NGL View in InterPro
5VFR U 786 - 917 NGL View in InterPro
5VFS U 786 - 917 NGL View in InterPro
5VFT U 786 - 917 NGL View in InterPro
5VFU U 786 - 917 NGL View in InterPro
6MSB U 786 - 917 NGL View in InterPro
6MSD U 786 - 917 NGL View in InterPro
6MSE U 786 - 917 NGL View in InterPro
6WJD U 786 - 917 NGL View in InterPro
6WJN U 786 - 917 NGL View in InterPro
786 - 925 5GJQ N 786 - 925 NGL View in InterPro
5GJR 1 786 - 925 NGL View in InterPro
N 786 - 925 NGL View in InterPro
5L4K N 786 - 925 NGL View in InterPro
5LN3 N 786 - 925 NGL View in InterPro
5VGZ U 786 - 925 NGL View in InterPro
5VHF U 786 - 925 NGL View in InterPro
5VHH U 786 - 925 NGL View in InterPro
5VHI U 786 - 925 NGL View in InterPro
5VHS U 786 - 925 NGL View in InterPro
6MSG U 786 - 925 NGL View in InterPro
6MSH U 786 - 925 NGL View in InterPro
6MSJ U 786 - 925 NGL View in InterPro
6MSK U 786 - 925 NGL View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in yellow.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;