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10  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: SORT_HUMAN (Q99523)

Summary

This is the summary of UniProt entry SORT_HUMAN (Q99523).

Description: Sortilin
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 831 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
sig_p n/a 1 33
low_complexity n/a 17 34
disorder n/a 33 46
low_complexity n/a 35 49
low_complexity n/a 59 77
disorder n/a 72 81
Pfam Sortilin-Vps10 142 572
low_complexity n/a 189 201
disorder n/a 442 452
Pfam Sortilin_C 574 740
transmembrane n/a 757 778
disorder n/a 806 809
disorder n/a 812 818
disorder n/a 820 828

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q99523. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MERPWGAADG LSRWPHGLGL LLLLQLLPPS TLSQDRLDAP PPPAAPLPRW
50
51
SGPIGVSWGL RAAAAGGAFP RGGRWRRSAP GEDEECGRVR DFVAKLANNT
100
101
HQHVFDDLRG SVSLSWVGDS TGVILVLTTF HVPLVIMTFG QSKLYRSEDY
150
151
GKNFKDITDL INNTFIRTEF GMAIGPENSG KVVLTAEVSG GSRGGRIFRS
200
201
SDFAKNFVQT DLPFHPLTQM MYSPQNSDYL LALSTENGLW VSKNFGGKWE
250
251
EIHKAVCLAK WGSDNTIFFT TYANGSCKAD LGALELWRTS DLGKSFKTIG
300
301
VKIYSFGLGG RFLFASVMAD KDTTRRIHVS TDQGDTWSMA QLPSVGQEQF
350
351
YSILAANDDM VFMHVDEPGD TGFGTIFTSD DRGIVYSKSL DRHLYTTTGG
400
401
ETDFTNVTSL RGVYITSVLS EDNSIQTMIT FDQGGRWTHL RKPENSECDA
450
451
TAKNKNECSL HIHASYSISQ KLNVPMAPLS EPNAVGIVIA HGSVGDAISV
500
501
MVPDVYISDD GGYSWTKMLE GPHYYTILDS GGIIVAIEHS SRPINVIKFS
550
551
TDEGQCWQTY TFTRDPIYFT GLASEPGARS MNISIWGFTE SFLTSQWVSY
600
601
TIDFKDILER NCEEKDYTIW LAHSTDPEDY EDGCILGYKE QFLRLRKSSV
650
651
CQNGRDYVVT KQPSICLCSL EDFLCDFGYY RPENDSKCVE QPELKGHDLE
700
701
FCLYGREEHL TTNGYRKIPG DKCQGGVNPV REVKDLKKKC TSNFLSPEKQ
750
751
NSKSNSVPII LAIVGLMLVT VVAGVLIVKK YVCGGRFLVH RYSVLQQHAE
800
801
ANGVDGVDAL DTASHTNKSG YHDDSDEDLL E                    
831
 

Show the unformatted sequence.

Checksums:
CRC64:91F96A3035A4B43A
MD5:e5e971b224b737636aebaad5215e9b93

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Sortilin-Vps10 142 - 572 3F6K A 109 - 539 NGL View in InterPro
4MSL A 109 - 539 NGL View in InterPro
4N7E A 109 - 539 NGL View in InterPro
4PO7 A 109 - 539 NGL View in InterPro
5MRH A 109 - 539 NGL View in InterPro
5MRI A 109 - 539 NGL View in InterPro
6EHO A 109 - 539 NGL View in InterPro
6X3L A 109 - 539 NGL View in InterPro
6X48 A 109 - 539 NGL View in InterPro
6X4H A 109 - 539 NGL View in InterPro
Sortilin_C 574 - 740 3F6K A 541 - 707 NGL View in InterPro
4MSL A 541 - 707 NGL View in InterPro
4N7E A 541 - 707 NGL View in InterPro
4PO7 A 541 - 707 NGL View in InterPro
5MRH A 541 - 707 NGL View in InterPro
5MRI A 541 - 707 NGL View in InterPro
6EHO A 541 - 707 NGL View in InterPro
6X3L A 541 - 707 NGL View in InterPro
6X48 A 541 - 707 NGL View in InterPro
6X4H A 541 - 707 NGL View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in yellow.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;