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0  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: SIAS_MOUSE (Q99J77)

Summary

This is the summary of UniProt entry SIAS_MOUSE (Q99J77).

Description: Sialic acid synthase {ECO:0000305|PubMed:10873658}
Source organism: Mus musculus (Mouse) (NCBI taxonomy ID 10090)
Length: 359 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
Pfam NeuB 39 278
disorder n/a 246 247
Pfam SAF 292 351
disorder n/a 347 354
disorder n/a 356 358

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q99J77. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MPLELELCPG RWVGGKHPCF IIAEIGQNHQ GDIDVAKRMI RTAKECGADC
50
51
AKFQKSELEF KFNRKALERP YTSKHSWGKT YGEHKRHLEF SHDQYKELQS
100
101
YAQEIGIFFT ASGMDEMAVE FLHELNVPFF KVGSGDTNNF PYLEKTAKKG
150
151
RPMVISSGMQ SMDTMKQVYQ IVKPLNPNFC FLQCTSAYPL QPEDANLRVI
200
201
SEYQKLFPDI PIGYSGHETG IAISVAAVAL GAKVLERHIT LDKTWKGSDH
250
251
SASLEPGELA ELVRSVRLVE RALGSPTKQL LPCEMACNEK LGKSVVAKVK
300
301
IPAGTTLTLD MLTVKVGEPK GYPPEDIFNL AGKKVLVTIE EDDTVMEESV
350
351
ESHSKKIKA                                             
359
 

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Checksums:
CRC64:4C66CB883558A373
MD5:7a868372a2a7b2930966f9e363ccc3d1

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;