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5  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: DDX23_HUMAN (Q9BUQ8)

Summary

This is the summary of UniProt entry DDX23_HUMAN (Q9BUQ8).

Description: Probable ATP-dependent RNA helicase DDX23 EC=3.6.4.13
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 820 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
disorder n/a 1 243
low_complexity n/a 19 110
coiled_coil n/a 65 85
low_complexity n/a 114 131
low_complexity n/a 125 138
low_complexity n/a 144 160
coiled_coil n/a 164 201
low_complexity n/a 175 197
low_complexity n/a 211 224
disorder n/a 245 246
disorder n/a 248 253
disorder n/a 320 321
coiled_coil n/a 323 350
low_complexity n/a 325 351
disorder n/a 334 340
disorder n/a 342 343
disorder n/a 388 391
Pfam DEAD 415 616
disorder n/a 568 591
disorder n/a 640 643
Pfam Helicase_C 650 759
disorder n/a 790 809

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q9BUQ8. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MAGELADKKD RDASPSKEER KRSRTPDRER DRDRDRKSSP SKDRKRHRSR
50
51
DRRRGGSRSR SRSRSKSAER ERRHKERERD KERDRNKKDR DRDKDGHRRD
100
101
KDRKRSSLSP GRGKDFKSRK DRDSKKDEED EHGDKKPKAQ PLSLEELLAK
150
151
KKAEEEAEAK PKFLSKAERE AEALKRRQQE VEERQRMLEE ERKKRKQFQD
200
201
LGRKMLEDPQ ERERRERRER MERETNGNED EEGRQKIREE KDKSKELHAI
250
251
KERYLGGIKK RRRTRHLNDR KFVFEWDASE DTSIDYNPLY KERHQVQLLG
300
301
RGFIAGIDLK QQKREQSRFY GDLMEKRRTL EEKEQEEARL RKLRKKEAKQ
350
351
RWDDRHWSQK KLDEMTDRDW RIFREDYSIT TKGGKIPNPI RSWKDSSLPP
400
401
HILEVIDKCG YKEPTPIQRQ AIPIGLQNRD IIGVAETGSG KTAAFLIPLL
450
451
VWITTLPKID RIEESDQGPY AIILAPTREL AQQIEEETIK FGKPLGIRTV
500
501
AVIGGISRED QGFRLRMGCE IVIATPGRLI DVLENRYLVL SRCTYVVLDE
550
551
ADRMIDMGFE PDVQKILEHM PVSNQKPDTD EAEDPEKMLA NFESGKHKYR
600
601
QTVMFTATMP PAVERLARSY LRRPAVVYIG SAGKPHERVE QKVFLMSESE
650
651
KRKKLLAILE QGFDPPIIIF VNQKKGCDVL AKSLEKMGYN ACTLHGGKGQ
700
701
EQREFALSNL KAGAKDILVA TDVAGRGIDI QDVSMVVNYD MAKNIEDYIH
750
751
RIGRTGRAGK SGVAITFLTK EDSAVFYELK QAILESPVSS CPPELANHPD
800
801
AQHKPGTILT KKRREETIFA                                 
820
 

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Checksums:
CRC64:01DD5BCF8BFBA2DB
MD5:a77b4323e539c5ca3e1d9c35940ac4d8

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
DEAD 415 - 616 3JCR F 415 - 616 Show 3D Structure View in InterPro
4NHO A 415 - 616 Show 3D Structure View in InterPro
6AH0 X 415 - 616 Show 3D Structure View in InterPro
6QW6 5X 415 - 616 Show 3D Structure View in InterPro
6QX9 5X 415 - 616 Show 3D Structure View in InterPro
Helicase_C 650 - 759 3JCR F 650 - 759 Show 3D Structure View in InterPro
4NHO A 650 - 759 Show 3D Structure View in InterPro
6AH0 X 650 - 759 Show 3D Structure View in InterPro
6QW6 5X 650 - 759 Show 3D Structure View in InterPro
6QX9 5X 650 - 759 Show 3D Structure View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;