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1  structure 1  species 0  interactions 1  sequence 1  architecture

Protein: S12A5_HUMAN (Q9H2X9)

Summary

This is the summary of UniProt entry S12A5_HUMAN (Q9H2X9).

Description: Solute carrier family 12 member 5
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 1139 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
disorder n/a 1 59
disorder n/a 62 69
disorder n/a 94 115
low_complexity n/a 100 113
Pfam AA_permease 125 328
transmembrane n/a 126 152
transmembrane n/a 158 182
transmembrane n/a 202 235
transmembrane n/a 255 272
transmembrane n/a 279 298
Pfam AA_permease 412 699
transmembrane n/a 419 439
transmembrane n/a 459 485
transmembrane n/a 505 523
transmembrane n/a 559 577
transmembrane n/a 583 605
transmembrane n/a 617 641
low_complexity n/a 669 686
Pfam SLC12 711 837
disorder n/a 749 752
Pfam SLC12 830 983
transmembrane n/a 851 868
disorder n/a 937 1060
low_complexity n/a 1003 1021
Pfam SLC12 1031 1139
disorder n/a 1063 1071
disorder n/a 1076 1079
disorder n/a 1090 1091
disorder n/a 1093 1111

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q9H2X9. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MSRRFTVTSL PPAGPARSPD PESRRHSVAD PRHLPGEDVK GDGNPKESSP
50
51
FINSTDTEKG KEYDGKNMAL FEEEMDTSPM VSSLLSGLAN YTNLPQGSRE
100
101
HEEAENNEGG KKKPVQAPRM GTFMGVYLPC LQNIFGVILF LRLTWVVGIA
150
151
GIMESFCMVF ICCSCTMLTA ISMSAIATNG VVPAGGSYYM ISRSLGPEFG
200
201
GAVGLCFYLG TTFAGAMYIL GTIEILLAYL FPAMAIFKAE DASGEAAAML
250
251
NNMRVYGTCV LTCMATVVFV GVKYVNKFAL VFLGCVILSI LAIYAGVIKS
300
301
AFDPPNFPIC LLGNRTLSRH GFDVCAKLAW EGNETVTTRL WGLFCSSRFL
350
351
NATCDEYFTR NNVTEIQGIP GAASGLIKEN LWSSYLTKGV IVERSGMTSV
400
401
GLADGTPIDM DHPYVFSDMT SYFTLLVGIY FPSVTGIMAG SNRSGDLRDA
450
451
QKSIPTGTIL AIATTSAVYI SSVVLFGACI EGVVLRDKFG EAVNGNLVVG
500
501
TLAWPSPWVI VIGSFFSTCG AGLQSLTGAP RLLQAISRDG IVPFLQVFGH
550
551
GKANGEPTWA LLLTACICEI GILIASLDEV APILSMFFLM CYMFVNLACA
600
601
VQTLLRTPNW RPRFRYYHWT LSFLGMSLCL ALMFICSWYY ALVAMLIAGL
650
651
IYKYIEYRGA EKEWGDGIRG LSLSAARYAL LRLEEGPPHT KNWRPQLLVL
700
701
VRVDQDQNVV HPQLLSLTSQ LKAGKGLTIV GSVLEGTFLE NHPQAQRAEE
750
751
SIRRLMEAEK VKGFCQVVIS SNLRDGVSHL IQSGGLGGLQ HNTVLVGWPR
800
801
NWRQKEDHQT WRNFIELVRE TTAGHLALLV TKNVSMFPGN PERFSEGSID
850
851
VWWIVHDGGM LMLLPFLLRH HKVWRKCKMR IFTVAQMDDN SIQMKKDLTT
900
901
FLYHLRITAE VEVVEMHESD ISAYTYEKTL VMEQRSQILK QMHLTKNERE
950
951
REIQSITDES RGSIRRKNPA NTRLRLNVPE ETAGDSEEKP EEEVQLIHDQ
1000
1001
SAPSCPSSSP SPGEEPEGEG ETDPEKVHLT WTKDKSVAEK NKGPSPVSSE
1050
1051
GIKDFFSMKP EWENLNQSNV RRMHTAVRLN EVIVKKSRDA KLVLLNMPGP
1100
1101
PRNRNGDENY MEFLEVLTEH LDRVMLVRGG GREVITIYS            
1139
 

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Checksums:
CRC64:100C097AF1FD4B3E
MD5:120d7fd2d7dc8a8203aa46555040b39f

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
AA_permease 125 - 328 6M23 A 102 - 305 NGL View in InterPro
B 102 - 305 NGL View in InterPro
412 - 699 6M23 A 389 - 676 NGL View in InterPro
B 389 - 676 NGL View in InterPro
SLC12 1031 - 1139 6M23 A 1008 - 1116 NGL View in InterPro
B 1008 - 1116 NGL View in InterPro
711 - 837 6M23 A 688 - 814 NGL View in InterPro
B 688 - 814 NGL View in InterPro
830 - 959 6M23 A 807 - 936 NGL View in InterPro
B 807 - 936 NGL View in InterPro
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The parts of the structure corresponding to the Pfam family are highlighted in yellow.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.