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70  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: DPOLM_HUMAN (Q9NP87)

Summary

This is the summary of UniProt entry DPOLM_HUMAN (Q9NP87).

Description: DNA-directed DNA/RNA polymerase mu EC=2.7.7.7
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 494 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
disorder n/a 1 23
disorder n/a 73 78
disorder n/a 80 88
disorder n/a 120 124
Pfam HHH_8 153 218
disorder n/a 154 155
low_complexity n/a 155 171
disorder n/a 199 200
low_complexity n/a 223 233
Pfam DNA_pol_lambd_f 238 287
disorder n/a 265 268
disorder n/a 270 286
Pfam DNA_pol_B_palm 290 387
Pfam DNA_pol_B_thumb 430 493

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q9NP87. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MLPKRRRARV GSPSGDAASS TPPSTRFPGV AIYLVEPRMG RSRRAFLTGL
50
51
ARSKGFRVLD ACSSEATHVV MEETSAEEAV SWQERRMAAA PPGCTPPALL
100
101
DISWLTESLG AGQPVPVECR HRLEVAGPRK GPLSPAWMPA YACQRPTPLT
150
151
HHNTGLSEAL EILAEAAGFE GSEGRLLTFC RAASVLKALP SPVTTLSQLQ
200
201
GLPHFGEHSS RVVQELLEHG VCEEVERVRR SERYQTMKLF TQIFGVGVKT
250
251
ADRWYREGLR TLDDLREQPQ KLTQQQKAGL QHHQDLSTPV LRSDVDALQQ
300
301
VVEEAVGQAL PGATVTLTGG FRRGKLQGHD VDFLITHPKE GQEAGLLPRV
350
351
MCRLQDQGLI LYHQHQHSCC ESPTRLAQQS HMDAFERSFC IFRLPQPPGA
400
401
AVGGSTRPCP SWKAVRVDLV VAPVSQFPFA LLGWTGSKLF QRELRRFSRK
450
451
EKGLWLNSHG LFDPEQKTFF QAASEEDIFR HLGLEYLPPE QRNA      
494
 

Show the unformatted sequence.

Checksums:
CRC64:B944059725F8B61F
MD5:fa60fd1b23fbcb1443e90ef1e7ff4e1d

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
DNA_pol_B_palm 290 - 387 4LZD A 290 - 387 Show 3D Structure View in InterPro
4LZG A 290 - 387 Show 3D Structure View in InterPro
4M04 A 290 - 387 Show 3D Structure View in InterPro
4M0A A 290 - 387 Show 3D Structure View in InterPro
4YCX A 290 - 387 Show 3D Structure View in InterPro
4YD1 A 290 - 387 Show 3D Structure View in InterPro
4YD2 A 290 - 387 Show 3D Structure View in InterPro
5TWP A 290 - 387 Show 3D Structure View in InterPro
5TWQ A 290 - 387 Show 3D Structure View in InterPro
5TWR A 290 - 387 Show 3D Structure View in InterPro
5TWS A 290 - 387 Show 3D Structure View in InterPro
5TXX A 290 - 387 Show 3D Structure View in InterPro
5TXZ A 290 - 387 Show 3D Structure View in InterPro
5TYB A 290 - 387 Show 3D Structure View in InterPro
5TYC A 290 - 387 Show 3D Structure View in InterPro
5TYD A 290 - 387 Show 3D Structure View in InterPro
5TYE A 290 - 387 Show 3D Structure View in InterPro
5TYF A 290 - 387 Show 3D Structure View in InterPro
5TYG A 290 - 387 Show 3D Structure View in InterPro
5TYU A 290 - 387 Show 3D Structure View in InterPro
5TYV A 290 - 387 Show 3D Structure View in InterPro
5TYW A 290 - 387 Show 3D Structure View in InterPro
5TYX A 290 - 387 Show 3D Structure View in InterPro
5TYY A 290 - 387 Show 3D Structure View in InterPro
5TYZ A 290 - 387 Show 3D Structure View in InterPro
5VZ7 A 290 - 387 Show 3D Structure View in InterPro
5VZ8 A 290 - 387 Show 3D Structure View in InterPro
5VZ9 A 290 - 387 Show 3D Structure View in InterPro
5VZA A 290 - 387 Show 3D Structure View in InterPro
5VZB A 290 - 387 Show 3D Structure View in InterPro
5VZC A 290 - 387 Show 3D Structure View in InterPro
5VZD A 290 - 387 Show 3D Structure View in InterPro
5VZE A 290 - 387 Show 3D Structure View in InterPro
5VZF A 290 - 387 Show 3D Structure View in InterPro
5VZG A 290 - 387 Show 3D Structure View in InterPro
5VZH A 290 - 387 Show 3D Structure View in InterPro
5VZI A 290 - 387 Show 3D Structure View in InterPro
5ZLC A 290 - 387 Show 3D Structure View in InterPro
6AEC A 290 - 387 Show 3D Structure View in InterPro
6AEH A 290 - 387 Show 3D Structure View in InterPro
6AK5 A 290 - 387 Show 3D Structure View in InterPro
6AK6 A 290 - 387 Show 3D Structure View in InterPro
6AK8 A 290 - 387 Show 3D Structure View in InterPro
6AK9 A 290 - 387 Show 3D Structure View in InterPro
6AKH A 290 - 387 Show 3D Structure View in InterPro
6IPD A 290 - 387 Show 3D Structure View in InterPro
6IPE A 290 - 387 Show 3D Structure View in InterPro
6IPF A 290 - 387 Show 3D Structure View in InterPro
6IPG A 290 - 387 Show 3D Structure View in InterPro
6IPH A 290 - 387 Show 3D Structure View in InterPro
6IPI A 290 - 387 Show 3D Structure View in InterPro
6IPJ A 290 - 387 Show 3D Structure View in InterPro
6IPK A 290 - 387 Show 3D Structure View in InterPro
6IPL A 290 - 387 Show 3D Structure View in InterPro
6IPM A 290 - 387 Show 3D Structure View in InterPro
6IPN A 290 - 387 Show 3D Structure View in InterPro
6P1M A 290 - 387 Show 3D Structure View in InterPro
6P1N A 290 - 387 Show 3D Structure View in InterPro
6P1O A 290 - 387 Show 3D Structure View in InterPro
6P1P A 290 - 387 Show 3D Structure View in InterPro
6P1Q A 290 - 387 Show 3D Structure View in InterPro
6P1R A 290 - 387 Show 3D Structure View in InterPro
6P1S A 290 - 387 Show 3D Structure View in InterPro
6P1T A 290 - 387 Show 3D Structure View in InterPro
6P1U A 290 - 387 Show 3D Structure View in InterPro
6P1V A 290 - 387 Show 3D Structure View in InterPro
6P1W A 290 - 387 Show 3D Structure View in InterPro
6WIC A 290 - 387 Show 3D Structure View in InterPro
6WID A 290 - 387 Show 3D Structure View in InterPro
6WIE A 290 - 387 Show 3D Structure View in InterPro
DNA_pol_B_thumb 430 - 493 4LZD A 430 - 493 Show 3D Structure View in InterPro
4LZG A 430 - 493 Show 3D Structure View in InterPro
4M04 A 430 - 493 Show 3D Structure View in InterPro
4M0A A 430 - 493 Show 3D Structure View in InterPro
4YCX A 430 - 493 Show 3D Structure View in InterPro
4YD1 A 430 - 493 Show 3D Structure View in InterPro
4YD2 A 430 - 493 Show 3D Structure View in InterPro
5TWP A 430 - 493 Show 3D Structure View in InterPro
5TWQ A 430 - 493 Show 3D Structure View in InterPro
5TWR A 430 - 493 Show 3D Structure View in InterPro
5TWS A 430 - 493 Show 3D Structure View in InterPro
5TXX A 430 - 493 Show 3D Structure View in InterPro
5TXZ A 430 - 493 Show 3D Structure View in InterPro
5TYB A 430 - 493 Show 3D Structure View in InterPro
5TYC A 430 - 493 Show 3D Structure View in InterPro
5TYD A 430 - 493 Show 3D Structure View in InterPro
5TYE A 430 - 493 Show 3D Structure View in InterPro
5TYF A 430 - 493 Show 3D Structure View in InterPro
5TYG A 430 - 493 Show 3D Structure View in InterPro
5TYU A 430 - 493 Show 3D Structure View in InterPro
5TYV A 430 - 493 Show 3D Structure View in InterPro
5TYW A 430 - 493 Show 3D Structure View in InterPro
5TYX A 430 - 493 Show 3D Structure View in InterPro
5TYY A 430 - 493 Show 3D Structure View in InterPro
5TYZ A 430 - 493 Show 3D Structure View in InterPro
5VZ7 A 430 - 493 Show 3D Structure View in InterPro
5VZ8 A 430 - 493 Show 3D Structure View in InterPro
5VZ9 A 430 - 493 Show 3D Structure View in InterPro
5VZA A 430 - 493 Show 3D Structure View in InterPro
5VZB A 430 - 493 Show 3D Structure View in InterPro
5VZC A 430 - 493 Show 3D Structure View in InterPro
5VZD A 430 - 493 Show 3D Structure View in InterPro
5VZE A 430 - 493 Show 3D Structure View in InterPro
5VZF A 430 - 493 Show 3D Structure View in InterPro
5VZG A 430 - 493 Show 3D Structure View in InterPro
5VZH A 430 - 493 Show 3D Structure View in InterPro
5VZI A 430 - 493 Show 3D Structure View in InterPro
5ZLC A 430 - 493 Show 3D Structure View in InterPro
6AEC A 430 - 493 Show 3D Structure View in InterPro
6AEH A 430 - 493 Show 3D Structure View in InterPro
6AK5 A 430 - 493 Show 3D Structure View in InterPro
6AK6 A 430 - 493 Show 3D Structure View in InterPro
6AK8 A 430 - 493 Show 3D Structure View in InterPro
6AK9 A 430 - 493 Show 3D Structure View in InterPro
6AKH A 430 - 493 Show 3D Structure View in InterPro
6IPD A 430 - 493 Show 3D Structure View in InterPro
6IPE A 430 - 493 Show 3D Structure View in InterPro
6IPF A 430 - 493 Show 3D Structure View in InterPro
6IPG A 430 - 493 Show 3D Structure View in InterPro
6IPH A 430 - 493 Show 3D Structure View in InterPro
6IPI A 430 - 493 Show 3D Structure View in InterPro
6IPJ A 430 - 493 Show 3D Structure View in InterPro
6IPK A 430 - 493 Show 3D Structure View in InterPro
6IPL A 430 - 493 Show 3D Structure View in InterPro
6IPM A 430 - 493 Show 3D Structure View in InterPro
6IPN A 430 - 493 Show 3D Structure View in InterPro
6P1M A 430 - 493 Show 3D Structure View in InterPro
6P1N A 430 - 493 Show 3D Structure View in InterPro
6P1O A 430 - 493 Show 3D Structure View in InterPro
6P1P A 430 - 493 Show 3D Structure View in InterPro
6P1Q A 430 - 493 Show 3D Structure View in InterPro
6P1R A 430 - 493 Show 3D Structure View in InterPro
6P1S A 430 - 493 Show 3D Structure View in InterPro
6P1T A 430 - 493 Show 3D Structure View in InterPro
6P1U A 430 - 493 Show 3D Structure View in InterPro
6P1V A 430 - 493 Show 3D Structure View in InterPro
6P1W A 430 - 493 Show 3D Structure View in InterPro
6WIC A 430 - 493 Show 3D Structure View in InterPro
6WID A 430 - 493 Show 3D Structure View in InterPro
6WIE A 430 - 493 Show 3D Structure View in InterPro
DNA_pol_lambd_f 238 - 287 4LZD A 238 - 287 Show 3D Structure View in InterPro
4LZG A 238 - 287 Show 3D Structure View in InterPro
4M04 A 238 - 287 Show 3D Structure View in InterPro
4M0A A 238 - 287 Show 3D Structure View in InterPro
4YCX A 238 - 287 Show 3D Structure View in InterPro
4YD1 A 238 - 287 Show 3D Structure View in InterPro
4YD2 A 238 - 287 Show 3D Structure View in InterPro
5TWP A 238 - 287 Show 3D Structure View in InterPro
5TWQ A 238 - 287 Show 3D Structure View in InterPro
5TWR A 238 - 287 Show 3D Structure View in InterPro
5TWS A 238 - 287 Show 3D Structure View in InterPro
5TXX A 238 - 287 Show 3D Structure View in InterPro
5TXZ A 238 - 287 Show 3D Structure View in InterPro
5TYB A 238 - 287 Show 3D Structure View in InterPro
5TYC A 238 - 287 Show 3D Structure View in InterPro
5TYD A 238 - 287 Show 3D Structure View in InterPro
5TYE A 238 - 287 Show 3D Structure View in InterPro
5TYF A 238 - 287 Show 3D Structure View in InterPro
5TYG A 238 - 287 Show 3D Structure View in InterPro
5TYU A 238 - 287 Show 3D Structure View in InterPro
5TYV A 238 - 287 Show 3D Structure View in InterPro
5TYW A 238 - 287 Show 3D Structure View in InterPro
5TYX A 238 - 287 Show 3D Structure View in InterPro
5TYY A 238 - 287 Show 3D Structure View in InterPro
5TYZ A 238 - 287 Show 3D Structure View in InterPro
5VZ7 A 238 - 287 Show 3D Structure View in InterPro
5VZ8 A 238 - 287 Show 3D Structure View in InterPro
5VZ9 A 238 - 287 Show 3D Structure View in InterPro
5VZA A 238 - 287 Show 3D Structure View in InterPro
5VZB A 238 - 287 Show 3D Structure View in InterPro
5VZC A 238 - 287 Show 3D Structure View in InterPro
5VZD A 238 - 287 Show 3D Structure View in InterPro
5VZE A 238 - 287 Show 3D Structure View in InterPro
5VZF A 238 - 287 Show 3D Structure View in InterPro
5VZG A 238 - 287 Show 3D Structure View in InterPro
5VZH A 238 - 287 Show 3D Structure View in InterPro
5VZI A 238 - 287 Show 3D Structure View in InterPro
5ZLC A 238 - 287 Show 3D Structure View in InterPro
6AEC A 238 - 287 Show 3D Structure View in InterPro
6AEH A 238 - 287 Show 3D Structure View in InterPro
6AK5 A 238 - 287 Show 3D Structure View in InterPro
6AK6 A 238 - 287 Show 3D Structure View in InterPro
6AK8 A 238 - 287 Show 3D Structure View in InterPro
6AK9 A 238 - 287 Show 3D Structure View in InterPro
6AKH A 238 - 287 Show 3D Structure View in InterPro
6IPD A 238 - 287 Show 3D Structure View in InterPro
6IPE A 238 - 287 Show 3D Structure View in InterPro
6IPF A 238 - 287 Show 3D Structure View in InterPro
6IPG A 238 - 287 Show 3D Structure View in InterPro
6IPH A 238 - 287 Show 3D Structure View in InterPro
6IPI A 238 - 287 Show 3D Structure View in InterPro
6IPJ A 238 - 287 Show 3D Structure View in InterPro
6IPK A 238 - 287 Show 3D Structure View in InterPro
6IPL A 238 - 287 Show 3D Structure View in InterPro
6IPM A 238 - 287 Show 3D Structure View in InterPro
6IPN A 238 - 287 Show 3D Structure View in InterPro
6P1M A 238 - 287 Show 3D Structure View in InterPro
6P1N A 238 - 287 Show 3D Structure View in InterPro
6P1O A 238 - 287 Show 3D Structure View in InterPro
6P1P A 238 - 287 Show 3D Structure View in InterPro
6P1Q A 238 - 287 Show 3D Structure View in InterPro
6P1R A 238 - 287 Show 3D Structure View in InterPro
6P1S A 238 - 287 Show 3D Structure View in InterPro
6P1T A 238 - 287 Show 3D Structure View in InterPro
6P1U A 238 - 287 Show 3D Structure View in InterPro
6P1V A 238 - 287 Show 3D Structure View in InterPro
6P1W A 238 - 287 Show 3D Structure View in InterPro
6WIC A 238 - 287 Show 3D Structure View in InterPro
6WID A 238 - 287 Show 3D Structure View in InterPro
6WIE A 238 - 287 Show 3D Structure View in InterPro
HHH_8 153 - 218 4LZD A 153 - 218 Show 3D Structure View in InterPro
4LZG A 153 - 218 Show 3D Structure View in InterPro
4M04 A 153 - 218 Show 3D Structure View in InterPro
4M0A A 153 - 218 Show 3D Structure View in InterPro
4YCX A 153 - 218 Show 3D Structure View in InterPro
4YD1 A 153 - 218 Show 3D Structure View in InterPro
4YD2 A 153 - 218 Show 3D Structure View in InterPro
5TWP A 153 - 218 Show 3D Structure View in InterPro
5TWQ A 153 - 218 Show 3D Structure View in InterPro
5TWR A 153 - 218 Show 3D Structure View in InterPro
5TWS A 153 - 218 Show 3D Structure View in InterPro
5TXX A 153 - 218 Show 3D Structure View in InterPro
5TXZ A 153 - 218 Show 3D Structure View in InterPro
5TYB A 153 - 218 Show 3D Structure View in InterPro
5TYC A 153 - 218 Show 3D Structure View in InterPro
5TYD A 153 - 218 Show 3D Structure View in InterPro
5TYE A 153 - 218 Show 3D Structure View in InterPro
5TYF A 153 - 218 Show 3D Structure View in InterPro
5TYG A 153 - 218 Show 3D Structure View in InterPro
5TYU A 153 - 218 Show 3D Structure View in InterPro
5TYV A 153 - 218 Show 3D Structure View in InterPro
5TYW A 153 - 218 Show 3D Structure View in InterPro
5TYX A 153 - 218 Show 3D Structure View in InterPro
5TYY A 153 - 218 Show 3D Structure View in InterPro
5TYZ A 153 - 218 Show 3D Structure View in InterPro
5VZ7 A 153 - 218 Show 3D Structure View in InterPro
5VZ8 A 153 - 218 Show 3D Structure View in InterPro
5VZ9 A 153 - 218 Show 3D Structure View in InterPro
5VZA A 153 - 218 Show 3D Structure View in InterPro
5VZB A 153 - 218 Show 3D Structure View in InterPro
5VZC A 153 - 218 Show 3D Structure View in InterPro
5VZD A 153 - 218 Show 3D Structure View in InterPro
5VZE A 153 - 218 Show 3D Structure View in InterPro
5VZF A 153 - 218 Show 3D Structure View in InterPro
5VZG A 153 - 218 Show 3D Structure View in InterPro
5VZH A 153 - 218 Show 3D Structure View in InterPro
5VZI A 153 - 218 Show 3D Structure View in InterPro
5ZLC A 153 - 218 Show 3D Structure View in InterPro
6AEC A 153 - 218 Show 3D Structure View in InterPro
6AEH A 153 - 218 Show 3D Structure View in InterPro
6AK5 A 153 - 218 Show 3D Structure View in InterPro
6AK6 A 153 - 218 Show 3D Structure View in InterPro
6AK8 A 153 - 218 Show 3D Structure View in InterPro
6AK9 A 153 - 218 Show 3D Structure View in InterPro
6AKH A 153 - 218 Show 3D Structure View in InterPro
6IPD A 153 - 218 Show 3D Structure View in InterPro
6IPE A 153 - 218 Show 3D Structure View in InterPro
6IPF A 153 - 218 Show 3D Structure View in InterPro
6IPG A 153 - 218 Show 3D Structure View in InterPro
6IPH A 153 - 218 Show 3D Structure View in InterPro
6IPI A 153 - 218 Show 3D Structure View in InterPro
6IPJ A 153 - 218 Show 3D Structure View in InterPro
6IPK A 153 - 218 Show 3D Structure View in InterPro
6IPL A 153 - 218 Show 3D Structure View in InterPro
6IPM A 153 - 218 Show 3D Structure View in InterPro
6IPN A 153 - 218 Show 3D Structure View in InterPro
6P1M A 153 - 218 Show 3D Structure View in InterPro
6P1N A 153 - 218 Show 3D Structure View in InterPro
6P1O A 153 - 218 Show 3D Structure View in InterPro
6P1P A 153 - 218 Show 3D Structure View in InterPro
6P1Q A 153 - 218 Show 3D Structure View in InterPro
6P1R A 153 - 218 Show 3D Structure View in InterPro
6P1S A 153 - 218 Show 3D Structure View in InterPro
6P1T A 153 - 218 Show 3D Structure View in InterPro
6P1U A 153 - 218 Show 3D Structure View in InterPro
6P1V A 153 - 218 Show 3D Structure View in InterPro
6P1W A 153 - 218 Show 3D Structure View in InterPro
6WIC A 153 - 218 Show 3D Structure View in InterPro
6WID A 153 - 218 Show 3D Structure View in InterPro
6WIE A 153 - 218 Show 3D Structure View in InterPro
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The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;