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7  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: INCE_HUMAN (Q9NQS7)

Summary

This is the summary of UniProt entry INCE_HUMAN (Q9NQS7).

Description: Inner centromere protein
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 918 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
disorder n/a 1 3
Pfam INCENP_N 6 41
disorder n/a 6 7
disorder n/a 45 116
low_complexity n/a 83 103
disorder n/a 118 119
disorder n/a 121 128
low_complexity n/a 127 140
disorder n/a 130 325
low_complexity n/a 137 153
low_complexity n/a 197 208
disorder n/a 329 353
disorder n/a 364 560
low_complexity n/a 377 394
low_complexity n/a 459 472
coiled_coil n/a 532 562
low_complexity n/a 558 582
disorder n/a 565 566
coiled_coil n/a 574 781
disorder n/a 583 638
low_complexity n/a 586 602
low_complexity n/a 608 640
low_complexity n/a 633 649
low_complexity n/a 641 665
disorder n/a 661 848
low_complexity n/a 661 747
low_complexity n/a 741 784
Pfam INCENP_ARK-bind 825 881
disorder n/a 892 901
disorder n/a 908 910

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q9NQS7. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MGTTAPGPIH LLELCDQKLM EFLCNMDNKD LVWLEEIQEE AERMFTREFS
50
51
KEPELMPKTP SQKNRRKKRR ISYVQDENRD PIRRRLSRRK SRSSQLSSRR
100
101
LRSKDSVEKL ATVVGENGSV LRRVTRAAAA AAAATMALAA PSSPTPESPT
150
151
MLTKKPEDNH TQCQLVPVVE IGISERQNAE QHVTQLMSTE PLPRTLSPTP
200
201
ASATAPTSQG IPTSDEESTP KKSKARILES ITVSSLMATP QDPKGQGVGT
250
251
GRSASKLRIA QVSPGPRDSP AFPDSPWRER VLAPILPDNF STPTGSRTDS
300
301
QSVRHSPIAP SSPSPQVLAQ KYSLVAKQES VVRRASRRLA KKTAEEPAAS
350
351
GRIICHSYLE RLLNVEVPQK VGSEQKEPPE EAEPVAAAEP EVPENNGNNS
400
401
WPHNDTEIAN STPNPKPAAS SPETPSAGQQ EAKTDQADGP REPPQSARRK
450
451
RSYKQAVSEL DEEQHLEDEE LQPPRSKTPS SPCPASKVVR PLRTFLHTVQ
500
501
RNQMLMTPTS APRSVMKSFI KRNTPLRMDP KCSFVEKERQ RLENLRRKEE
550
551
AEQLRRQKVE EDKRRRLEEV KLKREERLRK VLQARERVEQ MKEEKKKQIE
600
601
QKFAQIDEKT EKAKEERLAE EKAKKKAAAK KMEEVEARRK QEEEARRLRW
650
651
LQQEEEERRH QELLQKKKEE EQERLRKAAE AKRLAEQREQ ERREQERREQ
700
701
ERREQERREQ ERREQERQLA EQERRREQER LQAERELQER EKALRLQKEQ
750
751
LQRELEEKKK KEEQQRLAER QLQEEQEKKA KEAAGASKAL NVTVDVQSPA
800
801
CTSYQMTPQG HRAPPKINPD NYGMDLNSDD STDDEAHPRK PIPTWARGTP
850
851
LSQAIIHQYY HPPNLLELFG TILPLDLEDI FKKSKPRYHK RTSSAVWNSP
900
901
PLQGARVPSS LAYSLKKH                                   
918
 

Show the unformatted sequence.

Checksums:
CRC64:644D081DCC9035E8
MD5:5c0e61162c9e3e983849244f6f95bad8

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
INCENP_ARK-bind 838 - 881 6GR8 B 838 - 881 NGL View in InterPro
840 - 881 4AF3 D 840 - 881 NGL View in InterPro
841 - 881 6GR9 B 841 - 881 NGL View in InterPro
INCENP_N 6 - 41 2QFA C 6 - 41 NGL View in InterPro
6YIE F 6 - 41 NGL View in InterPro
7 - 41 6YIE C 7 - 41 NGL View in InterPro
6YIF C 7 - 41 NGL View in InterPro
6YIH C 7 - 41 NGL View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in yellow.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;