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4  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: FANCI_HUMAN (Q9NVI1)

Summary

This is the summary of UniProt entry FANCI_HUMAN (Q9NVI1).

Description: Fanconi anemia group I protein
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 1328 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
Pfam FANCI_S1-cap 1 53
Pfam FANCI_S1 62 280
Pfam FANCI_HD1 284 370
Pfam FANCI_S2 378 541
low_complexity n/a 549 574
Pfam FANCI_HD2 555 786
low_complexity n/a 637 647
low_complexity n/a 689 696
Pfam FANCI_S3 804 1032
disorder n/a 856 859
disorder n/a 861 862
low_complexity n/a 893 903
disorder n/a 942 945
low_complexity n/a 983 996
Pfam FANCI_S4 1045 1296
disorder n/a 1117 1118
disorder n/a 1120 1122
disorder n/a 1298 1328

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q9NVI1. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MDQKILSLAA EKTADKLQEF LQTLREGDLT NLLQNQAVKG KVAGALLRAI
50
51
FKGSPCSEEA GTLRRRKIYT CCIQLVESGD LQKEIASEII GLLMLEAHHF
100
101
PGPLLVELAN EFISAVREGS LVNGKSLELL PIILTALATK KENLAYGKGV
150
151
LSGEECKKQL INTLCSGRWD QQYVIQLTSM FKDVPLTAEE VEFVVEKALS
200
201
MFSKMNLQEI PPLVYQLLVL SSKGSRKSVL EGIIAFFSAL DKQHNEEQSG
250
251
DELLDVVTVP SGELRHVEGT IILHIVFAIK LDYELGRELV KHLKVGQQGD
300
301
SNNNLSPFSI ALLLSVTRIQ RFQDQVLDLL KTSVVKSFKD LQLLQGSKFL
350
351
QNLVPHRSYV STMILEVVKN SVHSWDHVTQ GLVELGFILM DSYGPKKVLD
400
401
GKTIETSPSL SRMPNQHACK LGANILLETF KIHEMIRQEI LEQVLNRVVT
450
451
RASSPISHFL DLLSNIVMYA PLVLQSCSSK VTEAFDYLSF LPLQTVQRLL
500
501
KAVQPLLKVS MSMRDCLILV LRKAMFANQL DARKSAVAGF LLLLKNFKVL
550
551
GSLSSSQCSQ SLSVSQVHVD VHSHYNSVAN ETFCLEIMDS LRRCLSQQAD
600
601
VRLMLYEGFY DVLRRNSQLA NSVMQTLLSQ LKQFYEPKPD LLPPLKLEAC
650
651
ILTQGDKISL QEPLDYLLCC IQHCLAWYKN TVIPLQQGEE EEEEEEAFYE
700
701
DLDDILESIT NRMIKSELED FELDKSADFS QSTSIGIKNN ICAFLVMGVC
750
751
EVLIEYNFSI SSFSKNRFED ILSLFMCYKK LSDILNEKAG KAKTKMANKT
800
801
SDSLLSMKFV SSLLTALFRD SIQSHQESLS VLRSSNEFMR YAVNVALQKV
850
851
QQLKETGHVS GPDGQNPEKI FQNLCDITRV LLWRYTSIPT SVEESGKKEK
900
901
GKSISLLCLE GLQKIFSAVQ QFYQPKIQQF LRALDVTDKE GEEREDADVS
950
951
VTQRTAFQIR QFQRSLLNLL SSQEEDFNSK EALLLVTVLT SLSKLLEPSS
1000
1001
PQFVQMLSWT SKICKENSRE DALFCKSLMN LLFSLHVSYK SPVILLRDLS
1050
1051
QDIHGHLGDI DQDVEVEKTN HFAIVNLRTA APTVCLLVLS QAEKVLEEVD
1100
1101
WLITKLKGQV SQETLSEEAS SQATLPNQPV EKAIIMQLGT LLTFFHELVQ
1150
1151
TALPSGSCVD TLLKDLCKMY TTLTALVRYY LQVCQSSGGI PKNMEKLVKL
1200
1201
SGSHLTPLCY SFISYVQNKS KSLNYTGEKK EKPAAVATAM ARVLRETKPI
1250
1251
PNLIFAIEQY EKFLIHLSKK SKVNLMQHMK LSTSRDFKIK GNILDMVLRE
1300
1301
DGEDENEEGT ASEHGGQNKE PAKKKRKK                        
1328
 

Show the unformatted sequence.

Checksums:
CRC64:07E80FD2F0BCCB32
MD5:b2fb63806cd50fd6b1b5f2c68ea20971

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
FANCI_HD1 284 - 370 6VAA A 284 - 370 NGL View in InterPro
6VAD A 284 - 370 NGL View in InterPro
6VAE A 284 - 370 NGL View in InterPro
6VAF A 284 - 370 NGL View in InterPro
FANCI_HD2 575 - 786 6VAA A 575 - 786 NGL View in InterPro
6VAD A 575 - 786 NGL View in InterPro
6VAE A 575 - 786 NGL View in InterPro
6VAF A 575 - 786 NGL View in InterPro
FANCI_S1 62 - 280 6VAA A 62 - 280 NGL View in InterPro
6VAD A 62 - 280 NGL View in InterPro
6VAE A 62 - 280 NGL View in InterPro
6VAF A 62 - 280 NGL View in InterPro
FANCI_S1-cap 1 - 53 6VAA A 1 - 53 NGL View in InterPro
6VAD A 1 - 53 NGL View in InterPro
6VAE A 1 - 53 NGL View in InterPro
6VAF A 1 - 53 NGL View in InterPro
FANCI_S2 378 - 541 6VAA A 378 - 541 NGL View in InterPro
6VAD A 378 - 541 NGL View in InterPro
6VAE A 378 - 541 NGL View in InterPro
6VAF A 378 - 541 NGL View in InterPro
FANCI_S3 804 - 1032 6VAA A 804 - 1032 NGL View in InterPro
6VAD A 804 - 1032 NGL View in InterPro
6VAE A 804 - 1032 NGL View in InterPro
6VAF A 804 - 1032 NGL View in InterPro
FANCI_S4 1045 - 1280 6VAA A 1045 - 1280 NGL View in InterPro
6VAD A 1045 - 1280 NGL View in InterPro
1045 - 1296 6VAE A 1045 - 1296 NGL View in InterPro
6VAF A 1045 - 1296 NGL View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in yellow.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;