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1  structure 1  species 0  interactions 1  sequence 1  architecture

Protein: DCL1_ARATH (Q9SP32)

Summary

This is the summary of UniProt entry DCL1_ARATH (Q9SP32).

Description: Endoribonuclease Dicer homolog 1 EC=3.1.26.-
Source organism: Arabidopsis thaliana (Mouse-ear cress) (NCBI taxonomy ID 3702)
Length: 1909 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
disorder n/a 1 6
disorder n/a 12 14
disorder n/a 39 41
disorder n/a 43 45
disorder n/a 47 48
disorder n/a 68 179
disorder n/a 186 190
disorder n/a 202 204
disorder n/a 212 216
disorder n/a 219 245
Pfam ResIII 235 417
low_complexity n/a 238 247
disorder n/a 514 515
low_complexity n/a 589 605
disorder n/a 602 624
Pfam Helicase_C 647 768
disorder n/a 706 707
disorder n/a 709 714
disorder n/a 796 803
Pfam Dicer_dimer 840 931
disorder n/a 862 865
disorder n/a 869 871
disorder n/a 929 952
Pfam PAZ 1184 1340
Pfam Ribonuclease_3 1375 1518
disorder n/a 1447 1449
disorder n/a 1460 1465
disorder n/a 1472 1482
low_complexity n/a 1478 1491
disorder n/a 1540 1542
disorder n/a 1544 1545
Pfam Ribonuclease_3 1594 1707
disorder n/a 1726 1744
disorder n/a 1746 1753
disorder n/a 1777 1780
low_complexity n/a 1782 1797
disorder n/a 1784 1787
low_complexity n/a 1790 1805
disorder n/a 1797 1833
low_complexity n/a 1808 1827
Pfam DND1_DSRM 1830 1905
disorder n/a 1851 1852
disorder n/a 1863 1865
disorder n/a 1877 1886

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q9SP32. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MVMEDEPREA TIKPSYWLDA CEDISCDLID DLVSEFDPSS VAVNESTDEN
50
51
GVINDFFGGI DHILDSIKNG GGLPNNGVSD TNSQINEVTV TPQVIAKETV
100
101
KENGLQKNGG KRDEFSKEEG DKDRKRARVC SYQSERSNLS GRGHVNNSRE
150
151
GDRFMNRKRT RNWDEAGNNK KKRECNNYRR DGRDREVRGY WERDKVGSNE
200
201
LVYRSGTWEA DHERDVKKVS GGNRECDVKA EENKSKPEER KEKVVEEQAR
250
251
RYQLDVLEQA KAKNTIAFLE TGAGKTLIAI LLIKSVHKDL MSQNRKMLSV
300
301
FLVPKVPLVY QQAEVIRNQT CFQVGHYCGE MGQDFWDSRR WQREFESKQV
350
351
LVMTAQILLN ILRHSIIRME TIDLLILDEC HHAVKKHPYS LVMSEFYHTT
400
401
PKDKRPAIFG MTASPVNLKG VSSQVDCAIK IRNLETKLDS TVCTIKDRKE
450
451
LEKHVPMPSE IVVEYDKAAT MWSLHETIKQ MIAAVEEAAQ ASSRKSKWQF
500
501
MGARDAGAKD ELRQVYGVSE RTESDGAANL IHKLRAINYT LAELGQWCAY
550
551
KVGQSFLSAL QSDERVNFQV DVKFQESYLS EVVSLLQCEL LEGAAAEKVA
600
601
AEVGKPENGN AHDEMEEGEL PDDPVVSGGE HVDEVIGAAV ADGKVTPKVQ
650
651
SLIKLLLKYQ HTADFRAIVF VERVVAALVL PKVFAELPSL SFIRCASMIG
700
701
HNNSQEMKSS QMQDTISKFR DGHVTLLVAT SVAEEGLDIR QCNVVMRFDL
750
751
AKTVLAYIQS RGRARKPGSD YILMVERGNV SHAAFLRNAR NSEETLRKEA
800
801
IERTDLSHLK DTSRLISIDA VPGTVYKVEA TGAMVSLNSA VGLVHFYCSQ
850
851
LPGDRYAILR PEFSMEKHEK PGGHTEYSCR LQLPCNAPFE ILEGPVCSSM
900
901
RLAQQAVCLA ACKKLHEMGA FTDMLLPDKG SGQDAEKADQ DDEGEPVPGT
950
951
ARHREFYPEG VADVLKGEWV SSGKEVCESS KLFHLYMYNV RCVDFGSSKD
1000
1001
PFLSEVSEFA ILFGNELDAE VLSMSMDLYV ARAMITKASL AFKGSLDITE
1050
1051
NQLSSLKKFH VRLMSIVLDV DVEPSTTPWD PAKAYLFVPV TDNTSMEPIK
1100
1101
GINWELVEKI TKTTAWDNPL QRARPDVYLG TNERTLGGDR REYGFGKLRH
1150
1151
NIVFGQKSHP TYGIRGAVAS FDVVRASGLL PVRDAFEKEV EEDLSKGKLM
1200
1201
MADGCMVAED LIGKIVTAAH SGKRFYVDSI CYDMSAETSF PRKEGYLGPL
1250
1251
EYNTYADYYK QKYGVDLNCK QQPLIKGRGV SYCKNLLSPR FEQSGESETV
1300
1301
LDKTYYVFLP PELCVVHPLS GSLIRGAQRL PSIMRRVESM LLAVQLKNLI
1350
1351
SYPIPTSKIL EALTAASCQE TFCYERAELL GDAYLKWVVS RFLFLKYPQK
1400
1401
HEGQLTRMRQ QMVSNMVLYQ FALVKGLQSY IQADRFAPSR WSAPGVPPVF
1450
1451
DEDTKDGGSS FFDEEQKPVS EENSDVFEDG EMEDGELEGD LSSYRVLSSK
1500
1501
TLADVVEALI GVYYVEGGKI AANHLMKWIG IHVEDDPDEV DGTLKNVNVP
1550
1551
ESVLKSIDFV GLERALKYEF KEKGLLVEAI THASRPSSGV SCYQRLEFVG
1600
1601
DAVLDHLITR HLFFTYTSLP PGRLTDLRAA AVNNENFARV AVKHKLHLYL
1650
1651
RHGSSALEKQ IREFVKEVQT ESSKPGFNSF GLGDCKAPKV LGDIVESIAG
1700
1701
AIFLDSGKDT TAAWKVFQPL LQPMVTPETL PMHPVRELQE RCQQQAEGLE
1750
1751
YKASRSGNTA TVEVFIDGVQ VGVAQNPQKK MAQKLAARNA LAALKEKEIA
1800
1801
ESKEKHINNG NAGEDQGENE NGNKKNGHQP FTRQTLNDIC LRKNWPMPSY
1850
1851
RCVKEGGPAH AKRFTFGVRV NTSDRGWTDE CIGEPMPSVK KAKDSAAVLL
1900
1901
LELLNKTFS                                             
1909
 

Show the unformatted sequence.

Checksums:
CRC64:EAA944F0C0C81D4C
MD5:d33e62a9047e6dd89883077a900d4c6e

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
DND1_DSRM 1837 - 1905 2LRS A 15 - 83 Show 3D Structure View in InterPro
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The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;