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14  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: REV1_HUMAN (Q9UBZ9)

Summary

This is the summary of UniProt entry REV1_HUMAN (Q9UBZ9).

Description: DNA repair protein REV1 EC=2.7.7.-
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 1251 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
disorder n/a 1 3
Pfam BRCT_2 45 130
disorder n/a 143 163
disorder n/a 175 177
disorder n/a 182 189
disorder n/a 193 241
disorder n/a 252 336
low_complexity n/a 321 333
low_complexity n/a 333 344
disorder n/a 382 388
disorder n/a 393 397
disorder n/a 403 406
Pfam IMS 422 622
disorder n/a 440 458
disorder n/a 486 487
disorder n/a 627 628
disorder n/a 705 710
Pfam IMS_C 709 837
low_complexity n/a 727 738
disorder n/a 827 843
disorder n/a 856 861
disorder n/a 863 864
disorder n/a 867 869
disorder n/a 872 876
disorder n/a 892 916
disorder n/a 924 929
Pfam UBM 931 957
disorder n/a 937 946
low_complexity n/a 952 964
disorder n/a 954 979
disorder n/a 987 997
disorder n/a 1000 1004
disorder n/a 1006 1008
Pfam UBM 1009 1042
disorder n/a 1031 1094
low_complexity n/a 1065 1078
disorder n/a 1097 1101
disorder n/a 1112 1121
disorder n/a 1123 1139
disorder n/a 1143 1150
Pfam REV1_C 1167 1248
low_complexity n/a 1196 1211

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q9UBZ9. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MRRGGWRKRA ENDGWETWGG YMAAKVQKLE EQFRSDAAMQ KDGTSSTIFS
50
51
GVAIYVNGYT DPSAEELRKL MMLHGGQYHV YYSRSKTTHI IATNLPNAKI
100
101
KELKGEKVIR PEWIVESIKA GRLLSYIPYQ LYTKQSSVQK GLSFNPVCRP
150
151
EDPLPGPSNI AKQLNNRVNH IVKKIETENE VKVNGMNSWN EEDENNDFSF
200
201
VDLEQTSPGR KQNGIPHPRG STAIFNGHTP SSNGALKTQD CLVPMVNSVA
250
251
SRLSPAFSQE EDKAEKSSTD FRDCTLQQLQ QSTRNTDALR NPHRTNSFSL
300
301
SPLHSNTKIN GAHHSTVQGP SSTKSTSSVS TFSKAAPSVP SKPSDCNFIS
350
351
NFYSHSRLHH ISMWKCELTE FVNTLQRQSN GIFPGREKLK KMKTGRSALV
400
401
VTDTGDMSVL NSPRHQSCIM HVDMDCFFVS VGIRNRPDLK GKPVAVTSNR
450
451
GTGRAPLRPG ANPQLEWQYY QNKILKGKAA DIPDSSLWEN PDSAQANGID
500
501
SVLSRAEIAS CSYEARQLGI KNGMFFGHAK QLCPNLQAVP YDFHAYKEVA
550
551
QTLYETLASY THNIEAVSCD EALVDITEIL AETKLTPDEF ANAVRMEIKD
600
601
QTKCAASVGI GSNILLARMA TRKAKPDGQY HLKPEEVDDF IRGQLVTNLP
650
651
GVGHSMESKL ASLGIKTCGD LQYMTMAKLQ KEFGPKTGQM LYRFCRGLDD
700
701
RPVRTEKERK SVSAEINYGI RFTQPKEAEA FLLSLSEEIQ RRLEATGMKG
750
751
KRLTLKIMVR KPGAPVETAK FGGHGICDNI ARTVTLDQAT DNAKIIGKAM
800
801
LNMFHTMKLN ISDMRGVGIH VNQLVPTNLN PSTCPSRPSV QSSHFPSGSY
850
851
SVRDVFQVQK AKKSTEEEHK EVFRAAVDLE ISSASRTCTF LPPFPAHLPT
900
901
SPDTNKAESS GKWNGLHTPV SVQSRLNLSI EVPSPSQLDQ SVLEALPPDL
950
951
REQVEQVCAV QQAESHGDKK KEPVNGCNTG ILPQPVGTVL LQIPEPQESN
1000
1001
SDAGINLIAL PAFSQVDPEV FAALPAELQR ELKAAYDQRQ RQGENSTHQQ
1050
1051
SASASVPKNP LLHLKAAVKE KKRNKKKKTI GSPKRIQSPL NNKLLNSPAK
1100
1101
TLPGACGSPQ KLIDGFLKHE GPPAEKPLEE LSASTSGVPG LSSLQSDPAG
1150
1151
CVRPPAPNLA GAVEFNDVKT LLREWITTIS DPMEEDILQV VKYCTDLIEE
1200
1201
KDLEKLDLVI KYMKRLMQQS VESVWNMAFD FILDNVQVVL QQTYGSTLKV
1250
1251
T                                                     
1251
 

Show the unformatted sequence.

Checksums:
CRC64:010E261D537DBA80
MD5:1af43d196f9b008d893c6e332b8726c9

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
BRCT_2 45 - 130 2EBW A 45 - 130 Show 3D Structure View in InterPro
IMS 422 - 622 3GQC A 422 - 622 Show 3D Structure View in InterPro
B 422 - 622 Show 3D Structure View in InterPro
C 422 - 622 Show 3D Structure View in InterPro
D 422 - 622 Show 3D Structure View in InterPro
IMS_C 709 - 827 3GQC C 709 - 827 Show 3D Structure View in InterPro
D 709 - 827 Show 3D Structure View in InterPro
709 - 828 3GQC A 709 - 828 Show 3D Structure View in InterPro
B 709 - 828 Show 3D Structure View in InterPro
REV1_C 1167 - 1242 4BA9 A 1167 - 1242 Show 3D Structure View in InterPro
B 1167 - 1242 Show 3D Structure View in InterPro
C 1167 - 1242 Show 3D Structure View in InterPro
D 1167 - 1242 Show 3D Structure View in InterPro
E 1167 - 1242 Show 3D Structure View in InterPro
F 1167 - 1242 Show 3D Structure View in InterPro
1167 - 1248 2LSI A 1167 - 1248 Show 3D Structure View in InterPro
2LSK A 1167 - 1248 Show 3D Structure View in InterPro
2LSY A 1167 - 1248 Show 3D Structure View in InterPro
2N1G A 1167 - 1248 Show 3D Structure View in InterPro
3VU7 H 1167 - 1248 Show 3D Structure View in InterPro
4EXT A 167 - 248 Show 3D Structure View in InterPro
4GK0 E 1167 - 1248 Show 3D Structure View in InterPro
F 1167 - 1248 Show 3D Structure View in InterPro
4GK5 E 1167 - 1248 Show 3D Structure View in InterPro
F 1167 - 1248 Show 3D Structure View in InterPro
UBM 1009 - 1039 6ASR B 1009 - 1039 Show 3D Structure View in InterPro
1009 - 1040 5VZM B 1008 - 1039 Show 3D Structure View in InterPro
6AXD A 41 - 72 Show 3D Structure View in InterPro
933 - 957 5VZM B 932 - 956 Show 3D Structure View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;