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3  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: LCMT1_HUMAN (Q9UIC8)

Summary

This is the summary of UniProt entry LCMT1_HUMAN (Q9UIC8).

Description: Leucine carboxyl methyltransferase 1
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 334 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
low_complexity n/a 8 19
Pfam LCM 25 217

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q9UIC8. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MATRQRESSI TSCCSTSSCD ADDEGVRGTC EDASLCKRFA VSIGYWHDPY
50
51
IQHFVRLSKE RKAPEINRGY FARVHGVSQL IKAFLRKTEC HCQIVNLGAG
100
101
MDTTFWRLKD EDLLPSKYFE VDFPMIVTRK LHSIKCKPPL SSPILELHSE
150
151
DTLQMDGHIL DSKRYAVIGA DLRDLSELEE KLKKCNMNTQ LPTLLIAECV
200
201
LVYMTPEQSA NLLKWAANSF ERAMFINYEQ VNMGDRFGQI MIENLRRRQC
250
251
DLAGVETCKS LESQKERLLS NGWETASAVD MMELYNRLPR AEVSRIESLE
300
301
FLDEMELLEQ LMRHYCLCWA TKGGNELGLK EITY                 
334
 

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Checksums:
CRC64:C8D200118E6F353D
MD5:10a0a39ee81842c4f7b67b6914b2507e

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
LCM 25 - 217 3IEI A 25 - 217 NGL View in InterPro
B 25 - 217 NGL View in InterPro
C 25 - 217 NGL View in InterPro
D 25 - 217 NGL View in InterPro
E 25 - 217 NGL View in InterPro
F 25 - 217 NGL View in InterPro
G 25 - 217 NGL View in InterPro
H 25 - 217 NGL View in InterPro
3P71 T 25 - 217 NGL View in InterPro
29 - 217 3O7W A 29 - 217 NGL View in InterPro
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TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.