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40  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: POLI_HUMAN (Q9UNA4)

Summary

This is the summary of UniProt entry POLI_HUMAN (Q9UNA4).

Description: DNA polymerase iota
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 740 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
disorder n/a 1 27
low_complexity n/a 5 30
disorder n/a 37 44
Pfam IMS 58 236
Pfam IMS_C 324 448
disorder n/a 463 466
disorder n/a 468 477
disorder n/a 479 497
disorder n/a 499 509
disorder n/a 543 546
disorder n/a 555 557
disorder n/a 580 612
low_complexity n/a 589 598
low_complexity n/a 605 624
disorder n/a 627 647
disorder n/a 666 702
disorder n/a 739 740

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q9UNA4. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MEKLGVEPEE EGGGDDDEED AEAWAMELAD VGAAASSQGV HDQVLPTPNA
50
51
SSRVIVHVDL DCFYAQVEMI SNPELKDKPL GVQQKYLVVT CNYEARKLGV
100
101
KKLMNVRDAK EKCPQLVLVN GEDLTRYREM SYKVTELLEE FSPVVERLGF
150
151
DENFVDLTEM VEKRLQQLQS DELSAVTVSG HVYNNQSINL LDVLHIRLLV
200
201
GSQIAAEMRE AMYNQLGLTG CAGVASNKLL AKLVSGVFKP NQQTVLLPES
250
251
CQHLIHSLNH IKEIPGIGYK TAKCLEALGI NSVRDLQTFS PKILEKELGI
300
301
SVAQRIQKLS FGEDNSPVIL SGPPQSFSEE DSFKKCSSEV EAKNKIEELL
350
351
ASLLNRVCQD GRKPHTVRLI IRRYSSEKHY GRESRQCPIP SHVIQKLGTG
400
401
NYDVMTPMVD ILMKLFRNMV NVKMPFHLTL LSVCFCNLKA LNTAKKGLID
450
451
YYLMPSLSTT SRSGKHSFKM KDTHMEDFPK DKETNRDFLP SGRIESTRTR
500
501
ESPLDTTNFS KEKDINEFPL CSLPEGVDQE VFKQLPVDIQ EEILSGKSRE
550
551
KFQGKGSVSC PLHASRGVLS FFSKKQMQDI PINPRDHLSS SKQVSSVSPC
600
601
EPGTSGFNSS SSSYMSSQKD YSYYLDNRLK DERISQGPKE PQGFHFTNSN
650
651
PAVSAFHSFP NLQSEQLFSR NHTTDSHKQT VATDSHEGLT ENREPDSVDE
700
701
KITFPSDIDP QVFYELPEAV QKELLAEWKR AGSDFHIGHK           
740
 

Show the unformatted sequence.

Checksums:
CRC64:C1A5BF0894E91FDF
MD5:44f7cd81574d924d07a91ac9b438e1ea

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
IMS 58 - 236 1T3N A 33 - 211 Show 3D Structure View in InterPro
B 453 - 631 Show 3D Structure View in InterPro
1ZET A 33 - 211 Show 3D Structure View in InterPro
2ALZ A 33 - 211 Show 3D Structure View in InterPro
2DPI A 33 - 211 Show 3D Structure View in InterPro
2DPJ A 33 - 211 Show 3D Structure View in InterPro
2FLL A 33 - 211 Show 3D Structure View in InterPro
2FLN A 33 - 211 Show 3D Structure View in InterPro
2FLP A 33 - 211 Show 3D Structure View in InterPro
3EPG A 33 - 211 Show 3D Structure View in InterPro
3EPI A 33 - 211 Show 3D Structure View in InterPro
3G6V A 33 - 211 Show 3D Structure View in InterPro
3G6X A 33 - 211 Show 3D Structure View in InterPro
3G6Y A 33 - 211 Show 3D Structure View in InterPro
3GV5 B 33 - 211 Show 3D Structure View in InterPro
D 33 - 211 Show 3D Structure View in InterPro
3GV7 B 33 - 211 Show 3D Structure View in InterPro
3GV8 B 33 - 211 Show 3D Structure View in InterPro
3H40 A 33 - 211 Show 3D Structure View in InterPro
3H4B A 33 - 211 Show 3D Structure View in InterPro
3H4D A 33 - 211 Show 3D Structure View in InterPro
3NGD A 33 - 211 Show 3D Structure View in InterPro
3OSN A 33 - 211 Show 3D Structure View in InterPro
3Q8P B 33 - 211 Show 3D Structure View in InterPro
3Q8Q B 33 - 211 Show 3D Structure View in InterPro
3Q8R B 33 - 211 Show 3D Structure View in InterPro
3Q8S B 33 - 211 Show 3D Structure View in InterPro
4EBC A 33 - 211 Show 3D Structure View in InterPro
4EBD A 33 - 211 Show 3D Structure View in InterPro
4EBE A 33 - 211 Show 3D Structure View in InterPro
4EYH B 33 - 211 Show 3D Structure View in InterPro
4EYI B 33 - 211 Show 3D Structure View in InterPro
4FS1 A 33 - 211 Show 3D Structure View in InterPro
4FS2 A 33 - 211 Show 3D Structure View in InterPro
5KT2 A 58 - 236 Show 3D Structure View in InterPro
5KT3 A 58 - 236 Show 3D Structure View in InterPro
5KT4 A 58 - 236 Show 3D Structure View in InterPro
5KT5 A 58 - 236 Show 3D Structure View in InterPro
5KT6 A 58 - 236 Show 3D Structure View in InterPro
5KT7 A 33 - 211 Show 3D Structure View in InterPro
5ULW A 33 - 211 Show 3D Structure View in InterPro
5ULX A 33 - 211 Show 3D Structure View in InterPro
IMS_C 324 - 439 1T3N A 299 - 414 Show 3D Structure View in InterPro
B 719 - 834 Show 3D Structure View in InterPro
1ZET A 299 - 414 Show 3D Structure View in InterPro
2ALZ A 299 - 414 Show 3D Structure View in InterPro
2DPI A 299 - 414 Show 3D Structure View in InterPro
2DPJ A 299 - 414 Show 3D Structure View in InterPro
2FLL A 299 - 414 Show 3D Structure View in InterPro
2FLN A 299 - 414 Show 3D Structure View in InterPro
2FLP A 299 - 414 Show 3D Structure View in InterPro
3EPG A 299 - 414 Show 3D Structure View in InterPro
3EPI A 299 - 414 Show 3D Structure View in InterPro
3G6V A 299 - 414 Show 3D Structure View in InterPro
3G6X A 299 - 414 Show 3D Structure View in InterPro
3G6Y A 299 - 414 Show 3D Structure View in InterPro
3GV5 B 299 - 414 Show 3D Structure View in InterPro
3GV7 B 299 - 414 Show 3D Structure View in InterPro
3GV8 B 299 - 414 Show 3D Structure View in InterPro
3H40 A 299 - 414 Show 3D Structure View in InterPro
3H4B A 299 - 414 Show 3D Structure View in InterPro
3H4D A 299 - 414 Show 3D Structure View in InterPro
3NGD A 299 - 414 Show 3D Structure View in InterPro
3OSN A 299 - 414 Show 3D Structure View in InterPro
3Q8P B 299 - 414 Show 3D Structure View in InterPro
3Q8Q B 299 - 414 Show 3D Structure View in InterPro
3Q8R B 299 - 414 Show 3D Structure View in InterPro
3Q8S B 299 - 414 Show 3D Structure View in InterPro
4EBC A 299 - 414 Show 3D Structure View in InterPro
4EBD A 299 - 414 Show 3D Structure View in InterPro
4EBE A 299 - 414 Show 3D Structure View in InterPro
4EYH B 299 - 414 Show 3D Structure View in InterPro
4FS1 A 299 - 414 Show 3D Structure View in InterPro
4FS2 A 299 - 414 Show 3D Structure View in InterPro
5KT2 A 324 - 439 Show 3D Structure View in InterPro
5KT3 A 324 - 439 Show 3D Structure View in InterPro
5KT4 A 324 - 439 Show 3D Structure View in InterPro
5KT5 A 324 - 439 Show 3D Structure View in InterPro
5KT6 A 324 - 439 Show 3D Structure View in InterPro
5KT7 A 299 - 414 Show 3D Structure View in InterPro
5ULW A 299 - 414 Show 3D Structure View in InterPro
5ULX A 299 - 414 Show 3D Structure View in InterPro
324 - 440 3GV5 D 299 - 415 Show 3D Structure View in InterPro
324 - 441 4EYI B 299 - 416 Show 3D Structure View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;