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0  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: SCN8A_HUMAN (Q9UQD0)

Summary

This is the summary of UniProt entry SCN8A_HUMAN (Q9UQD0).

Description: Sodium channel protein type 8 subunit alpha
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 1980 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

Show or hide the data used to generate the graphic in JSON format.

Source Domain Start End
disorder n/a 1 2
disorder n/a 9 10
disorder n/a 16 18
disorder n/a 28 29
disorder n/a 33 57
transmembrane n/a 128 151
Pfam Ion_trans 131 422
transmembrane n/a 199 219
transmembrane n/a 254 274
transmembrane n/a 348 366
transmembrane n/a 387 414
coiled_coil n/a 411 449
disorder n/a 422 427
low_complexity n/a 423 434
disorder n/a 433 434
low_complexity n/a 433 452
disorder n/a 446 535
low_complexity n/a 464 479
low_complexity n/a 473 489
low_complexity n/a 484 501
coiled_coil n/a 489 509
disorder n/a 540 543
Pfam Na_trans_cytopl 546 702
disorder n/a 551 554
disorder n/a 560 562
disorder n/a 566 572
disorder n/a 575 591
disorder n/a 593 602
low_complexity n/a 610 628
disorder n/a 614 618
low_complexity n/a 703 714
Pfam Ion_trans 752 987
transmembrane n/a 754 772
transmembrane n/a 784 802
transmembrane n/a 822 843
low_complexity n/a 840 852
transmembrane n/a 864 892
low_complexity n/a 880 892
transmembrane n/a 922 939
transmembrane n/a 951 977
low_complexity n/a 965 987
Pfam Na_trans_assoc 991 1193
disorder n/a 1055 1066
low_complexity n/a 1062 1073
disorder n/a 1070 1074
disorder n/a 1107 1143
low_complexity n/a 1141 1153
disorder n/a 1146 1148
Pfam Ion_trans 1197 1474
transmembrane n/a 1199 1217
transmembrane n/a 1238 1257
transmembrane n/a 1269 1292
low_complexity n/a 1294 1309
transmembrane n/a 1313 1341
transmembrane n/a 1438 1464
low_complexity n/a 1438 1454
Pfam Ion_trans 1521 1777
transmembrane n/a 1523 1541
transmembrane n/a 1553 1571
transmembrane n/a 1583 1603
transmembrane n/a 1609 1628
low_complexity n/a 1619 1631
transmembrane n/a 1640 1668
low_complexity n/a 1740 1758
transmembrane n/a 1743 1766
disorder n/a 1867 1868
disorder n/a 1876 1878
disorder n/a 1884 1888
Pfam IQ 1896 1916
disorder n/a 1921 1980
low_complexity n/a 1954 1974

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q9UQD0. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MAARLLAPPG PDSFKPFTPE SLANIERRIA ESKLKKPPKA DGSHREDDED
50
51
SKPKPNSDLE AGKSLPFIYG DIPQGLVAVP LEDFDPYYLT QKTFVVLNRG
100
101
KTLFRFSATP ALYILSPFNL IRRIAIKILI HSVFSMIIMC TILTNCVFMT
150
151
FSNPPDWSKN VEYTFTGIYT FESLVKIIAR GFCIDGFTFL RDPWNWLDFS
200
201
VIMMAYITEF VNLGNVSALR TFRVLRALKT ISVIPGLKTI VGALIQSVKK
250
251
LSDVMILTVF CLSVFALIGL QLFMGNLRNK CVVWPINFNE SYLENGTKGF
300
301
DWEEYINNKT NFYTVPGMLE PLLCGNSSDA GQCPEGYQCM KAGRNPNYGY
350
351
TSFDTFSWAF LALFRLMTQD YWENLYQLTL RAAGKTYMIF FVLVIFVGSF
400
401
YLVNLILAVV AMAYEEQNQA TLEEAEQKEA EFKAMLEQLK KQQEEAQAAA
450
451
MATSAGTVSE DAIEEEGEEG GGSPRSSSEI SKLSSKSAKE RRNRRKKRKQ
500
501
KELSEGEEKG DPEKVFKSES EDGMRRKAFR LPDNRIGRKF SIMNQSLLSI
550
551
PGSPFLSRHN SKSSIFSFRG PGRFRDPGSE NEFADDEHST VEESEGRRDS
600
601
LFIPIRARER RSSYSGYSGY SQGSRSSRIF PSLRRSVKRN STVDCNGVVS
650
651
LIGGPGSHIG GRLLPEATTE VEIKKKGPGS LLVSMDQLAS YGRKDRINSI
700
701
MSVVTNTLVE ELEESQRKCP PCWYKFANTF LIWECHPYWI KLKEIVNLIV
750
751
MDPFVDLAIT ICIVLNTLFM AMEHHPMTPQ FEHVLAVGNL VFTGIFTAEM
800
801
FLKLIAMDPY YYFQEGWNIF DGFIVSLSLM ELSLADVEGL SVLRSFRLLR
850
851
VFKLAKSWPT LNMLIKIIGN SVGALGNLTL VLAIIVFIFA VVGMQLFGKS
900
901
YKECVCKINQ DCELPRWHMH DFFHSFLIVF RVLCGEWIET MWDCMEVAGQ
950
951
AMCLIVFMMV MVIGNLVVLN LFLALLLSSF SADNLAATDD DGEMNNLQIS
1000
1001
VIRIKKGVAW TKLKVHAFMQ AHFKQREADE VKPLDELYEK KANCIANHTG
1050
1051
ADIHRNGDFQ KNGNGTTSGI GSSVEKYIID EDHMSFINNP NLTVRVPIAV
1100
1101
GESDFENLNT EDVSSESDPE GSKDKLDDTS SSEGSTIDIK PEVEEVPVEQ
1150
1151
PEEYLDPDAC FTEGCVQRFK CCQVNIEEGL GKSWWILRKT CFLIVEHNWF
1200
1201
ETFIIFMILL SSGALAFEDI YIEQRKTIRT ILEYADKVFT YIFILEMLLK
1250
1251
WTAYGFVKFF TNAWCWLDFL IVAVSLVSLI ANALGYSELG AIKSLRTLRA
1300
1301
LRPLRALSRF EGMRVVVNAL VGAIPSIMNV LLVCLIFWLI FSIMGVNLFA
1350
1351
GKYHYCFNET SEIRFEIEDV NNKTECEKLM EGNNTEIRWK NVKINFDNVG
1400
1401
AGYLALLQVA TFKGWMDIMY AAVDSRKPDE QPKYEDNIYM YIYFVIFIIF
1450
1451
GSFFTLNLFI GVIIDNFNQQ KKKFGGQDIF MTEEQKKYYN AMKKLGSKKP
1500
1501
QKPIPRPLNK IQGIVFDFVT QQAFDIVIMM LICLNMVTMM VETDTQSKQM
1550
1551
ENILYWINLV FVIFFTCECV LKMFALRHYY FTIGWNIFDF VVVILSIVGM
1600
1601
FLADIIEKYF VSPTLFRVIR LARIGRILRL IKGAKGIRTL LFALMMSLPA
1650
1651
LFNIGLLLFL VMFIFSIFGM SNFAYVKHEA GIDDMFNFET FGNSMICLFQ
1700
1701
ITTSAGWDGL LLPILNRPPD CSLDKEHPGS GFKGDCGNPS VGIFFFVSYI
1750
1751
IISFLIVVNM YIAIILENFS VATEESADPL SEDDFETFYE IWEKFDPDAT
1800
1801
QFIEYCKLAD FADALEHPLR VPKPNTIELI AMDLPMVSGD RIHCLDILFA
1850
1851
FTKRVLGDSG ELDILRQQME ERFVASNPSK VSYEPITTTL RRKQEEVSAV
1900
1901
VLQRAYRGHL ARRGFICKKT TSNKLENGGT HREKKESTPS TASLPSYDSV
1950
1951
TKPEKEKQQR AEEGRRERAK RQKEVRESKC                      
1980
 

Show the unformatted sequence.

Checksums:
CRC64:0EFC7BFB137FD4F0
MD5:b26c556ae611e0183c14572a8a88ec80

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;