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10  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: AAKB1_HUMAN (Q9Y478)

Summary

This is the summary of UniProt entry AAKB1_HUMAN (Q9Y478).

Description: 5'-AMP-activated protein kinase subunit beta-1
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 270 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
disorder n/a 1 51
disorder n/a 63 66
disorder n/a 68 69
disorder n/a 74 80
Pfam AMPK1_CBM 78 161
disorder n/a 139 140
disorder n/a 178 181
disorder n/a 187 188
disorder n/a 192 193
Pfam AMPKBI 199 269
low_complexity n/a 257 268

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q9Y478. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MGNTSSERAA LERHGGHKTP RRDSSGGTKD GDRPKILMDS PEDADLFHSE
50
51
EIKAPEKEEF LAWQHDLEVN DKAPAQARPT VFRWTGGGKE VYLSGSFNNW
100
101
SKLPLTRSHN NFVAILDLPE GEHQYKFFVD GQWTHDPSEP IVTSQLGTVN
150
151
NIIQVKKTDF EVFDALMVDS QKCSDVSELS SSPPGPYHQE PYVCKPEERF
200
201
RAPPILPPHL LQVILNKDTG ISCDPALLPE PNHVMLNHLY ALSIKDGVMV
250
251
LSATHRYKKK YVTTLLYKPI                                 
270
 

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Checksums:
CRC64:F0BCAA94D5BC15FC
MD5:0c797fb41dedad836ac1052c22bda398

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
AMPK1_CBM 78 - 161 4CFE B 78 - 161 NGL View in InterPro
D 78 - 161 NGL View in InterPro
4CFF B 78 - 161 NGL View in InterPro
D 78 - 161 NGL View in InterPro
4ZHX B 78 - 161 NGL View in InterPro
D 78 - 161 NGL View in InterPro
5EZV B 78 - 161 NGL View in InterPro
D 78 - 161 NGL View in InterPro
5ISO B 78 - 161 NGL View in InterPro
D 78 - 161 NGL View in InterPro
6B1U B 78 - 161 NGL View in InterPro
D 78 - 161 NGL View in InterPro
6C9F B 78 - 161 NGL View in InterPro
6C9G B 78 - 161 NGL View in InterPro
6C9H B 78 - 161 NGL View in InterPro
6C9J B 78 - 161 NGL View in InterPro
AMPKBI 199 - 269 5EZV B 199 - 269 NGL View in InterPro
D 199 - 269 NGL View in InterPro
6B1U B 199 - 269 NGL View in InterPro
200 - 269 4ZHX B 200 - 269 NGL View in InterPro
201 - 269 4ZHX D 201 - 269 NGL View in InterPro
5ISO B 201 - 269 NGL View in InterPro
6B1U D 201 - 269 NGL View in InterPro
6C9F B 201 - 269 NGL View in InterPro
6C9G B 201 - 269 NGL View in InterPro
6C9H B 201 - 269 NGL View in InterPro
6C9J B 201 - 269 NGL View in InterPro
202 - 269 5ISO D 202 - 269 NGL View in InterPro
203 - 269 4CFE B 203 - 269 NGL View in InterPro
D 203 - 269 NGL View in InterPro
4CFF B 203 - 269 NGL View in InterPro
D 203 - 269 NGL View in InterPro
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TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.