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0  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: IRS2_HUMAN (Q9Y4H2)

Summary

This is the summary of UniProt entry IRS2_HUMAN (Q9Y4H2).

Description: Insulin receptor substrate 2
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 1338 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
disorder n/a 1 36
low_complexity n/a 19 28
Pfam PH 31 144
disorder n/a 47 81
low_complexity n/a 52 67
low_complexity n/a 148 180
Pfam IRS 194 296
disorder n/a 304 347
low_complexity n/a 304 312
disorder n/a 349 505
low_complexity n/a 369 380
low_complexity n/a 444 478
low_complexity n/a 481 493
disorder n/a 508 544
low_complexity n/a 533 537
disorder n/a 551 600
disorder n/a 629 678
low_complexity n/a 659 669
disorder n/a 680 690
low_complexity n/a 692 719
disorder n/a 694 735
low_complexity n/a 729 738
disorder n/a 738 739
disorder n/a 760 775
disorder n/a 777 790
disorder n/a 825 1321
low_complexity n/a 861 877
low_complexity n/a 931 967
low_complexity n/a 984 996
low_complexity n/a 1005 1046
low_complexity n/a 1080 1096
low_complexity n/a 1148 1165
low_complexity n/a 1188 1197
low_complexity n/a 1204 1219
low_complexity n/a 1222 1238
low_complexity n/a 1262 1279
low_complexity n/a 1298 1316
disorder n/a 1336 1338

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q9Y4H2. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MASPPRHGPP GPASGDGPNL NNNNNNNNHS VRKCGYLRKQ KHGHKRFFVL
50
51
RGPGAGGDEA TAGGGSAPQP PRLEYYESEK KWRSKAGAPK RVIALDCCLN
100
101
INKRADAKHK YLIALYTKDE YFAVAAENEQ EQEGWYRALT DLVSEGRAAA
150
151
GDAPPAAAPA ASCSASLPGA LGGSAGAAGA EDSYGLVAPA TAAYREVWQV
200
201
NLKPKGLGQS KNLTGVYRLC LSARTIGFVK LNCEQPSVTL QLMNIRRCGH
250
251
SDSFFFIEVG RSAVTGPGEL WMQADDSVVA QNIHETILEA MKALKELFEF
300
301
RPRSKSQSSG SSATHPISVP GARRHHHLVN LPPSQTGLVR RSRTDSLAAT
350
351
PPAAKCSSCR VRTASEGDGG AAAGAAAAGA RPVSVAGSPL SPGPVRAPLS
400
401
RSHTLSGGCG GRGSKVALLP AGGALQHSRS MSMPVAHSPP AATSPGSLSS
450
451
SSGHGSGSYP PPPGPHPPLP HPLHHGPGQR PSSGSASASG SPSDPGFMSL
500
501
DEYGSSPGDL RAFCSHRSNT PESIAETPPA RDGGGGGEFY GYMTMDRPLS
550
551
HCGRSYRRVS GDAAQDLDRG LRKRTYSLTT PARQRPVPQP SSASLDEYTL
600
601
MRATFSGSAG RLCPSCPASS PKVAYHPYPE DYGDIEIGSH RSSSSNLGAD
650
651
DGYMPMTPGA ALAGSGSGSC RSDDYMPMSP ASVSAPKQIL QPRAAAAAAA
700
701
AVPSAGPAGP APTSAAGRTF PASGGGYKAS SPAESSPEDS GYMRMWCGSK
750
751
LSMEHADGKL LPNGDYLNVS PSDAVTTGTP PDFFSAALHP GGEPLRGVPG
800
801
CCYSSLPRSY KAPYTCGGDS DQYVLMSSPV GRILEEERLE PQATPGPSQA
850
851
ASAFGAGPTQ PPHPVVPSPV RPSGGRPEGF LGQRGRAVRP TRLSLEGLPS
900
901
LPSMHEYPLP PEPKSPGEYI NIDFGEPGAR LSPPAPPLLA SAASSSSLLS
950
951
ASSPASSLGS GTPGTSSDSR QRSPLSDYMN LDFSSPKSPK PGAPSGHPVG
1000
1001
SLDGLLSPEA SSPYPPLPPR PSASPSSSLQ PPPPPPAPGE LYRLPPASAV
1050
1051
ATAQGPGAAS SLSSDTGDNG DYTEMAFGVA ATPPQPIAAP PKPEAARVAS
1100
1101
PTSGVKRLSL MEQVSGVEAF LQASQPPDPH RGAKVIRADP QGGRRRHSSE
1150
1151
TFSSTTTVTP VSPSFAHNPK RHNSASVENV SLRKSSEGGV GVGPGGGDEP
1200
1201
PTSPRQLQPA PPLAPQGRPW TPGQPGGLVG CPGSGGSPMR RETSAGFQNG
1250
1251
LNYIAIDVRE EPGLPPQPQP PPPPLPQPGD KSSWGRTRSL GGLISAVGVG
1300
1301
STGGGCGGPG PGALPPANTY ASIDFLSHHL KEATIVKE             
1338
 

Show the unformatted sequence.

Checksums:
CRC64:58E569E8BDBAF3D7
MD5:442dc4d6f8fac36c37a9e958db70f6f3

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.