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2  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: RIPK3_HUMAN (Q9Y572)

Summary

This is the summary of UniProt entry RIPK3_HUMAN (Q9Y572).

Description: Receptor-interacting serine/threonine-protein kinase 3 {ECO:0000305}
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 518 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
Pfam Pkinase 21 283
low_complexity n/a 110 121
low_complexity n/a 161 184
disorder n/a 169 175
disorder n/a 177 179
disorder n/a 240 254
disorder n/a 277 280
disorder n/a 291 292
disorder n/a 301 302
disorder n/a 311 456
low_complexity n/a 409 423
Pfam RHIM 417 468
disorder n/a 460 518

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q9Y572. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MSCVKLWPSG APAPLVSIEE LENQELVGKG GFGTVFRAQH RKWGYDVAVK
50
51
IVNSKAISRE VKAMASLDNE FVLRLEGVIE KVNWDQDPKP ALVTKFMENG
100
101
SLSGLLQSQC PRPWPLLCRL LKEVVLGMFY LHDQNPVLLH RDLKPSNVLL
150
151
DPELHVKLAD FGLSTFQGGS QSGTGSGEPG GTLGYLAPEL FVNVNRKAST
200
201
ASDVYSFGIL MWAVLAGREV ELPTEPSLVY EAVCNRQNRP SLAELPQAGP
250
251
ETPGLEGLKE LMQLCWSSEP KDRPSFQECL PKTDEVFQMV ENNMNAAVST
300
301
VKDFLSQLRS SNRRFSIPES GQGGTEMDGF RRTIENQHSR NDVMVSEWLN
350
351
KLNLEEPPSS VPKKCPSLTK RSRAQEEQVP QAWTAGTSSD SMAQPPQTPE
400
401
TSTFRNQMPS PTSTGTPSPG PRGNQGAERQ GMNWSCRTPE PNPVTGRPLV
450
451
NIYNCSGVQV GDNNYLTMQQ TTALPTWGLA PSGKGRGLQH PPPVGSQEGP
500
501
KDPEAWSRPQ GWYNHSGK                                   
518
 

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Checksums:
CRC64:BF755F8A0B1810A1
MD5:ec33234cbdc2a0f075f70d2df498c55a

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
RHIM 448 - 462 5V7Z A 448 - 462 NGL View in InterPro
C 448 - 462 NGL View in InterPro
E 448 - 462 NGL View in InterPro
G 448 - 462 NGL View in InterPro
458 - 461 5ZCK A 1 - 4 NGL View in InterPro
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The parts of the structure corresponding to the Pfam family are highlighted in yellow.

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TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.