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1  structure 1  species 0  interactions 1  sequence 1  architecture

Protein: PIAS3_HUMAN (Q9Y6X2)

Summary

This is the summary of UniProt entry PIAS3_HUMAN (Q9Y6X2).

Description: E3 SUMO-protein ligase PIAS3 EC=2.3.2.-
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 628 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
low_complexity n/a 34 46
low_complexity n/a 70 93
disorder n/a 75 84
disorder n/a 86 95
low_complexity n/a 90 109
disorder n/a 98 100
disorder n/a 111 123
Pfam PINIT 126 278
disorder n/a 226 242
disorder n/a 244 245
Pfam zf-MIZ 323 372
disorder n/a 429 436
disorder n/a 438 456
disorder n/a 458 466
disorder n/a 481 482
disorder n/a 486 499
disorder n/a 543 547
disorder n/a 579 586
disorder n/a 588 615
low_complexity n/a 608 617

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q9Y6X2. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MAELGELKHM VMSFRVSELQ VLLGFAGRNK SGRKHELLAK ALHLLKSSCA
50
51
PSVQMKIKEL YRRRFPRKTL GPSDLSLLSL PPGTSPVGSP GPLAPIPPTL
100
101
LAPGTLLGPK REVDMHPPLP QPVHPDVTMK PLPFYEVYGE LIRPTTLAST
150
151
SSQRFEEAHF TFALTPQQVQ QILTSREVLP GAKCDYTIQV QLRFCLCETS
200
201
CPQEDYFPPN LFVKVNGKLC PLPGYLPPTK NGAEPKRPSR PINITPLARL
250
251
SATVPNTIVV NWSSEFGRNY SLSVYLVRQL TAGTLLQKLR AKGIRNPDHS
300
301
RALIKEKLTA DPDSEVATTS LRVSLMCPLG KMRLTVPCRA LTCAHLQSFD
350
351
AALYLQMNEK KPTWTCPVCD KKAPYESLII DGLFMEILSS CSDCDEIQFM
400
401
EDGSWCPMKP KKEASEVCPP PGYGLDGLQY SPVQGGDPSE NKKKVEVIDL
450
451
TIESSSDEED LPPTKKHCSV TSAAIPALPG SKGVLTSGHQ PSSVLRSPAM
500
501
GTLGGDFLSS LPLHEYPPAF PLGADIQGLD LFSFLQTESQ HYGPSVITSL
550
551
DEQDALGHFF QYRGTPSHFL GPLAPTLGSS HCSATPAPPP GRVSSIVAPG
600
601
GALREGHGGP LPSGPSLTGC RSDIISLD                        
628
 

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Checksums:
CRC64:7C06EF599D48F87D
MD5:a43db6f9b8044cdb846734b6fd4f8196

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
PINIT 126 - 278 4MVT A 126 - 278 NGL View in InterPro
B 126 - 278 NGL View in InterPro
C 126 - 278 NGL View in InterPro
D 126 - 278 NGL View in InterPro
zf-MIZ 323 - 372 4MVT A 323 - 372 NGL View in InterPro
B 323 - 372 NGL View in InterPro
C 323 - 372 NGL View in InterPro
D 323 - 372 NGL View in InterPro
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The parts of the structure corresponding to the Pfam family are highlighted in yellow.

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TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.