Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
1  structure 1  species 0  interactions 6  sequences 3  architectures

Structure: 5ISO

Summary

5iso
PDB entry 5iso: STRUCTURE OF FULL LENGTH HUMAN AMPK (NON-PHOSPHORYLATED AT T-LOOP) IN COMPLEX WITH A SMALL MOLECULE ACTIVATOR, A BENZIMIDAZOLE DERIVATIVE (991)
Enlarge image.

PDB entry 5iso

Structure of full length human ampk (non-phosphorylated at t-loop) in complex with a small molecule activator, a benzimidazole derivative (991)

Experiment type: X-ray diffraction, resolution 2.63Å
Release date: 2019-10-16
Authors: Xiao, B., Hubbard, J.A., Gamblin, S.J.
Species: Homo sapiens (Human)

PDBprint

Below is the PDBprint for entry 5iso.

External database links

Domain organisation

Many structures in the PDB are linked to one or more UniProt protein sequence entries. This section shows the Pfam domains which are found on the UniProt sequence(s) referred to by this structure.

Loading domain graphics...

Sequence mapping

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from PDBe, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the sequences and Pfam domains that correspond to this structure.

PDB UniProt Pfam family
Chain Start End ID Start End
A 16 268 P54646 16 268 Pkinase (PF00069)
A 401 474 P54646 401 474 AdenylateSensor (PF16579)
B 78 161 Q9Y478 78 161 AMPK1_CBM (PF16561)
B 201 269 Q9Y478 201 269 AMPKBI (PF04739)
C 16 268 P54646 16 268 Pkinase (PF00069)
C 401 474 P54646 401 474 AdenylateSensor (PF16579)
D 78 161 Q9Y478 78 161 AMPK1_CBM (PF16561)
D 202 269 Q9Y478 202 269 AMPKBI (PF04739)
E 120 178 P54619 120 178 CBS (PF00571)
E 185 252 P54619 185 252 CBS (PF00571)
E 269 324 P54619 269 324 CBS (PF00571)
F 120 178 P54619 120 178 CBS (PF00571)
F 185 252 P54619 185 252 CBS (PF00571)
F 269 324 P54619 269 324 CBS (PF00571)

Note: This mapping was provided by the PDBe group.

View structure

Clich here to see an interactive view of 5iso below.

Loading Structure Data

View Pfam families and other data mapped to the structure of PDB entry 5iso in InterPro