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1  structure 1  species 0  interactions 41  sequences 31  architectures

Structure: 5MQF

Summary

5mqf
PDB entry 5mqf: Cryo-EM structure of a human spliceosome activated for step 2 of splicing (C* complex)
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PDB entry 5mqf

Cryo-em structure of a human spliceosome activated for step 2 of splicing (c* complex)

Experiment type: Electron Microscopy, resolution 5.90Å
Release date: 2018-11-21
Authors: Bertram, K., Hartmuth, K., Kastner, B.
Species: Homo sapiens (Human)

PDBprint

Below is the PDBprint for entry 5mqf.

External database links

Domain organisation

Many structures in the PDB are linked to one or more UniProt protein sequence entries. This section shows the Pfam domains which are found on the UniProt sequence(s) referred to by this structure.

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Sequence mapping

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from PDBe, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the sequences and Pfam domains that correspond to this structure.

PDB UniProt Pfam family
Chain Start End ID Start End
a 33 111 P62316 33 111 LSM (PF01423)
A 58 209 Q6P2Q9 58 209 PRO8NT (PF08082)
A 395 801 Q6P2Q9 395 801 PROCN (PF08083)
A 986 1077 Q6P2Q9 986 1077 RRM_4 (PF10598)
A 1210 1343 Q6P2Q9 1210 1343 U5_2-snRNA_bdg (PF10597)
A 1442 1600 Q6P2Q9 1442 1600 U6-snRNA_bdg (PF10596)
A 1760 1989 Q6P2Q9 1760 1989 PRP8_domainIV (PF12134)
b 9 74 P62306 9 74 LSM (PF01423)
B 56 110 Q15029 56 110 EFTUD2 (PF16004)
B 127 440 Q15029 127 440 GTP_EFTU (PF00009)
B 489 566 Q15029 489 566 GTP_EFTU_D2 (PF03144)
B 584 656 Q15029 584 656 EFG_III (PF14492)
B 703 824 Q15029 703 824 EFG_IV (PF03764)
B 826 915 Q15029 826 915 EFG_C (PF00679)
c 23 89 P62304 23 89 LSM (PF01423)
C 175 334 Q13573 175 334 SKIP_SNW (PF02731)
d 7 72 P62308 7 72 LSM (PF01423)
D 194 232 O43660 194 232 WD40 (PF00400)
D 236 274 O43660 236 274 WD40 (PF00400)
D 278 316 O43660 278 316 WD40 (PF00400)
D 320 358 O43660 320 358 WD40 (PF00400)
D 403 440 O43660 403 440 WD40 (PF00400)
e 8 73 P62318 8 73 LSM (PF01423)
E 278 317 O60508 278 317 WD40 (PF00400)
E 322 360 O60508 322 360 WD40 (PF00400)
E 408 446 O60508 408 446 WD40 (PF00400)
E 496 536 O60508 496 536 WD40 (PF00400)
E 540 579 O60508 540 579 WD40 (PF00400)
f 7 82 P14678 7 82 LSM (PF01423)
F 56 94 Q96DI7 56 94 WD40 (PF00400)
F 99 137 Q96DI7 99 137 WD40 (PF00400)
F 141 180 Q96DI7 141 180 WD40 (PF00400)
F 186 221 Q96DI7 186 221 WD40 (PF00400)
F 224 263 Q96DI7 224 263 WD40 (PF00400)
F 271 313 Q96DI7 271 313 WD40 (PF00400)
F 317 353 Q96DI7 317 353 WD40 (PF00400)
G 3 57 Q9UMS4 3 57 U-box (PF04564)
g 5 70 P62314 5 70 LSM (PF01423)
G 67 134 Q9UMS4 67 134 Prp19 (PF08606)
H 3 57 Q9UMS4 3 57 U-box (PF04564)
h 33 111 P62316 33 111 LSM (PF01423)
H 67 134 Q9UMS4 67 134 Prp19 (PF08606)
I 3 57 Q9UMS4 3 57 U-box (PF04564)
i 9 74 P62306 9 74 LSM (PF01423)
I 67 134 Q9UMS4 67 134 Prp19 (PF08606)
J 3 57 Q9UMS4 3 57 U-box (PF04564)
j 23 89 P62304 23 89 LSM (PF01423)
J 67 134 Q9UMS4 67 134 Prp19 (PF08606)
k 7 72 P62308 7 72 LSM (PF01423)
K 13 216 O75934 13 216 BCAS2 (PF05700)
l 8 73 P62318 8 73 LSM (PF01423)
L 11 71 Q99459 11 71 Myb_DNA-bind_6 (PF13921)
L 63 111 Q99459 63 111 Myb_DNA-bind_6 (PF13921)
m 7 82 P14678 7 82 LSM (PF01423)
M 256 285 Q9HCS7 256 285 TPR_8 (PF13181)
M 395 428 Q9HCS7 395 428 TPR_8 (PF13181)
n 5 70 P62314 5 70 LSM (PF01423)
N 128 238 O95926 128 238 SYF2 (PF08231)
o 8 78 Q9UNP9 8 78 RRM_1 (PF00076)
o 143 299 Q9UNP9 143 299 Pro_isomerase (PF00160)
O 256 288 Q9BZJ0 256 288 HAT (PF02184)
O 357 388 Q9BZJ0 357 388 HAT (PF02184)
p 62 228 P38919 62 228 DEAD (PF00270)
P 234 299 Q9NW64 234 299 RRM_1 (PF00076)
p 263 372 P38919 263 372 Helicase_C (PF00271)
Q 3 144 P41223 3 144 G10 (PF01125)
q 758 897 Q14562 756 895 Helicase_C (PF00271)
q 957 1045 Q14562 957 1045 HA2 (PF04408)
q 1103 1180 Q14562 1103 1180 OB_NTP_bind (PF07717)
R 23 229 Q9P013 23 229 Cwf_Cwc_15 (PF04889)
T 455 561 Q9HCG8 455 561 MA3 (PF02847)
U 19 802 O60306 19 802 Aquarius_N (PF16399)
U 801 1107 O60306 801 1107 AAA_11 (PF13086)
U 1115 1308 O60306 1115 1308 AAA_12 (PF13087)
V 13 163 Q9Y3C6 13 163 Pro_isomerase (PF00160)
W 2 163 P09661 2 163 LRR_9 (PF14580)
X 12 83 P08579 9 80 RRM_1 (PF00076)

Note: This mapping was provided by the PDBe group.

View structure

View Pfam families and other data mapped to the structure of PDB entry 5mqf in InterPro